Pediatric Coinfection With Malaria and Epstein-Barr Virus

Wilkerson, Hannah; Maniam, Ganesh; Dean, Ryan; Bewaji, Tosin; Okotcha, Efe; Mattamal, Raphael

doi:10.25270/con.2020.07.00007

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Medicinal Attributes Of Oxadiazole Derivatives1

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2022

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“…Malaria remained a major health problem in Africa and Asia and occurred in more than hundred countries. [ 103 ] More than 229 million cases of malaria were found annually. [ 104 ] The protozoan species were causing agents for malaria.…”

Section: Medicinal Attributes Of Oxadiazole Derivativesmentioning

confidence: 99%

Oxadiazole: A highly versatile scaffold in drug discovery

Desai

Monapara

Jethawa

et al. 2022

Archiv der Pharmazie

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As a pharmacologically important heterocycle, oxadiazole paved the way to combat the problem associated with the confluence of many commercially available drugs with different pharmacological profiles. The present review focuses on the potential applications of five-membered heterocyclic oxadiazole derivatives, especially 1,2,4-oxadiazole, 1,2,5-oxadiazole, and 1,3,4-oxadiazole, as therapeutic agents. Designing new hybrid molecules containing the oxadiazole moiety is a better solution for the development of new drug molecules. The designed molecules may accumulate a biological profile better than those of the drugs currently available on the market. The present review will guide the way for researchers in the field of medicinal chemistry to design new biologically active molecules based on the oxadiazole nucleus. Antitubercular, antimalarial, anti-inflammatory, anti-HIV, antibacterial, and anticancer activities of various oxadiazoles have been reviewed extensively here.

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Section: Medicinal Attributes Of Oxadiazole Derivativesmentioning

confidence: 99%