Pediatric diabetes in China: Challenges and actions

Wang, Jinling; Wu, Wei; Dong, Guanping; Huang, Ke; zhang, jianwei

doi:10.1111/pedi.13344

Cited by 14 publications

(9 citation statements)

References 49 publications

(104 reference statements)

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“…Once a rare disease in youth, T2D is becoming more common and accounts for a significant proportion of youth onset diabetes in certain at‐risk populations. Worldwide incidence and prevalence of T2D in children and adolescents vary substantially among countries, age categories and ethnic groups 129–134 . The incidence and prevalence of T2D are highest among youth from a minority race/ethnicity, 99 likely because of many factors, including genetics, metabolic characteristics, cultural/environmental influences, and quality of and access to health care 135,136 …”

Section: Epidemiology Of T2dmentioning

confidence: 99%

ISPAD Clinical Practice Consensus Guidelines 2022: Definition, epidemiology, and classification of diabetes in children and adolescents

et al. 2022

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Section: Epidemiology Of T2dmentioning

confidence: 99%

ISPAD Clinical Practice Consensus Guidelines 2022: Definition, epidemiology, and classification of diabetes in children and adolescents

et al. 2022

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“…The incidence of T1DM is increasing worldwide. Recent studies have shown that the overall population incidence of T1DM in China is 1.01 per 100,000 people per year [3], and the annual incidence of childhood with T1DM is about 2.02~5.3 per 100,000 [4]. The pathogenesis of T1DM has not been clearly defined so far, but it is generally thought to be due to multiple factors such as gene susceptibility and environment [5].…”

Section: Introductionmentioning

confidence: 99%

Progress in the Relationship between Vitamin D Deficiency and the Incidence of Type 1 Diabetes Mellitus in Children

Song

Tao

et al. 2022

Journal of Diabetes Research

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Type 1 diabetes mellitus (T1DM) is an autoimmune disease, due to a large number of islet β cells damaged, resulting in an absolute lack of insulin, ultimately relying on insulin therapy. Vitamin D is a fat-soluble sterol derivative that not only participates in calcium and phosphorus metabolism but also acts as an immunomodulatory role by binding to nuclear vitamin D receptors to regulate the expression of transcription factors. Increasing evidence has shown that vitamin D has immunoregulation and anti-inflammatory effects, and it may play a role in T cell regulatory responses due to downregulation in the expression of cathepsin G and inhibition of CD4+ T cell activation and protection of β cells from immune attack and is beneficial in decreasing oxidative stress in T1DM patients. Epidemiologic evidence demonstrates involvement of vitamin D deficiency in T1DM pathogenesis, with the immune system improperly targeting and destroying its own islet β cells. In addition, polymorphisms in genes critical for vitamin D metabolism may increase the risk of islet autoimmunity and T1DM. In this paper, the relationship between vitamin D deficiency and the molecular mechanism of T1DM was discussed.

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“…The number of T1D children has increased sharply in recent years [ 29 ], how to face the risks from pandemic is a challenge for patients and their parents. A cross-sectional study involving 98 children and adolescents with T1D identified several key challenges faced by Iranian patients due to pandemic restrictions.…”

Section: Epidemiologymentioning

confidence: 99%

Covid 19 and diabetes in children: advances and strategies

Wu,

Wang,

Ullah

et al. 2024

Diabetol Metab Syndr

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Background Throughout the COVID-19 pandemic, there has been a notable increase in the incidence of new-onset diabetes and diabetic ketoacidosis (DKA). Simultaneously, children diagnosed with type 1 diabetes (T1D) have encountered difficulties in maintaining optimal blood glucose levels. The mechanisms underpinning these correlations still remain a puzzle. We reviewed the studies that examined changes in incidence during the pandemic. These studies utilized various metrics for comparison, which encompassed the timing of data collection, diagnostic criteria, as well as the numbers and incidence rates of diabetes and DKA. We found the incidence of diabetes and DKA was higher during the pandemic. As to mechanisms, the invivo and invitro study revealed the factors such as direct viral damage, metabolic dysfunction, and immune responses all attribute to the process of T1D after suffering from COVID-19. Furthermore, we provide some useful strategies to prevent and treat children suffering from diabetes and COVID-19. Conclusions: Strong correlations have been observed between new-onset diabetes and COVID-19. Insights gleaned from clinical descriptions and basic research can offer valuable experience and recommendations for the treatment and prevention of diabetes during future pandemics.

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Pediatric diabetes in China: Challenges and actions

Cited by 14 publications

References 49 publications

ISPAD Clinical Practice Consensus Guidelines 2022: Definition, epidemiology, and classification of diabetes in children and adolescents

ISPAD Clinical Practice Consensus Guidelines 2022: Definition, epidemiology, and classification of diabetes in children and adolescents

Progress in the Relationship between Vitamin D Deficiency and the Incidence of Type 1 Diabetes Mellitus in Children

Covid 19 and diabetes in children: advances and strategies

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