Pediatric Emergency Research in the UK and Ireland (PERUKI): developing a collaborative for multicentre research

Cleugh, Francesca; Alcock, Roger; Barling, J.; Bayreuther, Jane; Bevan, C; Blackburn, Carol; Bolger, Turlough; Brown, Alaina E.; Burke, Donald A.; Choudhery, V.; Criddle, John; Davies, Fraser; Dickson-Jardine, K.; Dieppe, Clare; Gilby, Elizabeth; Hartshorn, Stuart; Leonard, P.; Lenton, K.; Lyttle, Mark D; Maconochie, Ian; Maney, Julie-Ann; Marzouk, O.; McNamara, Robert S.; Mitchelson, Mark; Mullen, Niall; Mulligan, Joe; O’Sullivan, Ronan; Parikh, A; Potier, Katherine; Powell, Catherine; Reuben, Aaron; Robinson, George M.; Ross, James; Rowland, Anna; Smith, Jami S.; Sutherland, Edwin H.; Thiagarajan, J.; Thomas, Lindsey A.; Vorwerk, Christiane; Wong, Syue-Jhao; Younge, P. A.

doi:10.1136/archdischild-2013-304998

Cited by 60 publications

(66 citation statements)

References 4 publications

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“…Paediatric Emergency Research in the UK and Ireland (PERUKI) was established in August 2012 as a collaborative clinical studies group among individuals passionate about providing high-quality PEM research 4. From its inception, many lessons were learned from the principles adhered to by other PEM research networks, with the aims of overcoming the inherent challenges of conducting studies and increasing PEM research in line with the national agenda for the greater involvement of children in research 5.…”

Section: Introductionmentioning

confidence: 99%

Establishing the research priorities of paediatric emergency medicine clinicians in the UK and Ireland

et al. 2015

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Section: Introductionmentioning

confidence: 99%

Establishing the research priorities of paediatric emergency medicine clinicians in the UK and Ireland

et al. 2015

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“…Each round ran for 4 weeks, separated by 4–6 weeks to allow analysis and interpretation of responses. The study was led by Paediatric Emergency Research in the UK and Ireland (PERUKI) 15 in association with General and Adolescent Paediatric Research in the UK and Ireland (GAPRUKI). PERUKI is a collaborative PEM research network whose membership at the time consisted of 53 EDs, with a mix of secondary and tertiary sites in urban and rural locations.…”

Section: Methodsmentioning

confidence: 99%

Defining significant childhood illness and injury in the Emergency Department: a consensus of UK and Ireland expert opinion

et al. 2018

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BackgroundClarifying whether paediatric early warning scores (PEWS) accurately predict significant illness is a research priority for UK and Ireland paediatric emergency medicine (EM). However, a standardised list of significant conditions to benchmark these scores does not exist.ObjectivesTo establish standardised significant illness endpoints for use in determining the performance accuracy of PEWS and safety systems in emergency departments (ED), using a consensus of expert opinion in the UK and Ireland.DesignBetween July 2017 and February 2018, three online Delphi rounds established a consensus on ‘significant’ clinical conditions, derived from a list of common childhood illness/injury ED presentations. Conditions warranting acute hospital admission in the opinion of the respondent were defined as ‘significant’, using a 5-point Likert scale. The consensus was a priori ≥80% (positive or negative). 258 clinical conditions were tested.Participants and settingsEligible participants were consultants in acute or EM paediatrics, or adult EM, accessed via 53 PERUKI (Paediatric Emergency Research in the UK and Ireland)’s research collaborative sites, and 27 GAPRUKI (General and Adolescent Paediatric Research in the UK and Ireland)’s sites, 17 of which overlap with PERUKI.Main outcome measuresTo create a list of conditions regarded as ‘significant’with ≥80% expert consensus.Results43 (68%) of 63 PERUKI and GAPRUKI sites responded; 295 experts were invited to participate. Participants in rounds 1, 2 and 3 were 223 (76%), 177 (60%) and 148 (50%), respectively; 154 conditions reached positive consensus as ‘significant’; 1 condition reached a negative consensus (uncomplicated Henoch-Schönlein purpura); and 37 conditions achieved non-consensus.ConclusionsA list of significant childhood conditions has been created using UK and Irish expert consensus, for research purposes, for the first time. This will be used as the benchmark endpoint list for future research into PEWS/safety systems performance in EDs.

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“…Paediatric Emergency Research in the United Kingdom and Ireland (PERUKI)15 sites participated in a two-stage survey via Bristol Online Surveys. Stage one assessed department practice, including information on clinical practice guidelines (CPG), care pathways (CP) and site-specific features including admission location.…”

Section: Methodsmentioning

confidence: 99%

“…Returns were collated using Microsoft Excel 2010 and descriptive analysis was undertaken. PERUKI is a research collaborative of individuals and departments from England, Ireland, Northern Ireland, Scotland and Wales which comprises paediatric-specific and mixed adult and paediatric EDs that represent secondary and tertiary care 15. Further information is available online (…”

Section: Methodsmentioning

confidence: 99%

Variation in treatment of acute childhood wheeze in emergency departments of the United Kingdom and Ireland: an international survey of clinician practice

et al. 2014

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Objective National clinical guidelines for childhood wheeze exist, yet despite being one of the most common reasons for childhood emergency department (ED) attendance, significant variation in practice occurs in other settings. We, therefore, evaluated practice variations of ED clinicians in the UK and Ireland. Conclusions Significant variation in ED consultant management of childhood wheeze exists despite the presence of national guidance. This reflects the lack of evidence in key areas of childhood wheeze and emphasises the need for further robust multicentre research studies.

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Pediatric Emergency Research in the UK and Ireland (PERUKI): developing a collaborative for multicentre research

Cited by 60 publications

References 4 publications

Establishing the research priorities of paediatric emergency medicine clinicians in the UK and Ireland

Establishing the research priorities of paediatric emergency medicine clinicians in the UK and Ireland

Defining significant childhood illness and injury in the Emergency Department: a consensus of UK and Ireland expert opinion

Variation in treatment of acute childhood wheeze in emergency departments of the United Kingdom and Ireland: an international survey of clinician practice

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