Pediatric Erythema Annulare Centrifugum Treated with Oral Fluconazole: A Retrospective Series

Abstract

Oral fluconazole was an effective treatment in five children with EAC.

An observational study of the efficacy of azithromycin in erythema annulare centrifugum

“…In our work, all patients were young to middle‐aged adults, and there was a female preponderance, which is consistent with the existing studies . The histology was largely consistent with the clinical diagnosis, except for three cases where a mixed pattern was seen . Identification and elimination of the cause is seldom possible, and in our study also no aetiology was discovered even with thorough examination and relevant investigations.…”

“…3,4 The histology was largely consistent with the clinical diagnosis, except for three cases where a mixed pattern was seen. 3,4 Identification and elimination of the cause is seldom possible, and in our study also no aetiology was discovered even with thorough examination and relevant investigations. The low dose of 250 mg utilizes the anti-inflammatory effect of azithromycin as opposed to its antibacterial effect.…”

“…The superficial type is associated with a higher recurrence rate and a shorter duration of skin lesions compared with the deep type . The existing treatment methods that have been tried in EAC include steroids (topical and oral); topical vitamin D analogues, topical tacrolimus, oral erythromycin, metronidazole and fluconazole and imunosuppressives such as etanercept, which have been occasionally administered in chronic and recurrent cases of EAC …”

“…3 The existing treatment methods that have been tried in EAC include steroids (topical and oral); topical vitamin D analogues, topical tacrolimus, oral erythromycin, metronidazole and fluconazole and imunosuppressives such as etanercept, which have been occasionally administered in chronic and recurrent cases of EAC. 4 We identified idiopathic cases of EAC and administered oral azithromycin 250 mg once daily for varying periods. The interplay of IL-1, TNF with NF-jB and NO are considered as principle mediators of biological response to the bacterial lipopolysaccharides (endotoxins) and many other infectious stimuli.…”

Refractory erythema annulare centrifugum treated with apremilast

“…There is also limited evidence for the use of calcipotriene, tacrolimus, narrow-band UV-B, fluconazole, oral metronidazole, and subcutaneous interferon-alpha. 2 , 3 , 4 , 5 …”