Pediatric Ewing sarcoma of the head and neck: A retrospective survival analysis

Martin, Elaine; Radomski, Shannon; Harley, Earl H.

doi:10.1016/j.ijporl.2018.11.026

Cited by 18 publications

(12 citation statements)

References 13 publications

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“…Surgery has been considered a routine and important treatment that affects prognosis; however, the treatment outcomes of radiotherapy remain controversial 18, 19, 21 . Until now, the validity of surgery and radiotherapy lacked evidence.…”

Section: Discussionmentioning

confidence: 99%

“…A previous study with a median follow-up of 10 years reported a 5-year OS of 33% in patients with localized disease and 0% for metastatic patients. Surgery has been considered a routine and important treatment that affects prognosis; however, the treatment outcomes of radiotherapy remain controversial 18,19,21 . Until now, the validity of surgery and radiotherapy lacked evidence.…”

Section: Epidemiological Analysis and Identification Of Prognostic Famentioning

confidence: 99%

“…Therefore, careful evaluation of the clinical, radiographic, and pathologic features is necessary to diagnose BA. The management of patients with BA depends on prognostic factors including epidemiologic characteristics, tumor characteristics, and treatment modalities [14][15][16][17][18][19] . Although any age in the general population may be affected, the incidence of BA is highest between 50 and 70 years of age 12 and age is considered an independent risk factor for survival in cases appearing in the spine 20 .…”

Section: Introductionmentioning

confidence: 99%

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A Clinical Model of Bone Angiosarcoma Patients: A Population‐based Analysis of Epidemiology, Prognosis, and Treatment

Wang

Chen

Wang

2020

Orthopaedic Surgery

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Objective: To investigate the epidemiological data, prognostic factors, and treatment outcomes of bone angiosarcoma (BA). Methods: This retrospective study was based on the Surveillance, Epidemiology, and End Results (SEER) database. The medical records of BA patients were selected from the SEER database from 1975 to 2016. Variables including patients' baseline demographics (age, sex, marital status, and year of diagnosis), tumor characteristics (tumor size, grade, and SEER Historic Stage A), and treatment (surgery and radiotherapy) were selected for further analysis. The research endpoints were overall survival (OS) and cancer-specific survival (CSS). The optimal cutoff values of continuous variables including age, year of diagnosis, and tumor size were identified using the X-tail program. Univariate Cox regression was used to identify potential prognostic factors and multivariate Cox regression was used to identify independent prognostic factors. All prognostic factors were included to predict the survival time compared to the median OS and CSS times via the novel nomograms. To validate the internal validation of nomograms, we analyzed the concordance indices (C-index). Results: This study enrolled a total of 271 patients with malignant vascular bone tumors among residents of the United States between 1975 and 2016. After applying the exclusion criteria (one case without active follow-up), this study included 152 patients with BA. The median survival time of BA was significantly shorter than that of malignant vascular bone tumors for OS (9 months vs 27 months, P < 0.001). Age, year of diagnosis, tumor size, grade, stage, and surgery were identified as potential prognostic factors for OS or CSS in univariate Cox regression. However, only age (P < 0.001, P < 0.001), stage (P = 0.002, P < 0.001), and surgery (P = 0.001, P = 0.002) were independent prognostic factors for CSS and OS, respectively, in the multivariate analysis. Younger patients less than 54 years have significantly better prognosis for CSS/OS than patients between 54 and 67 years (Hazard ratios [HRs]: 1.651 [1.763-3.575], 2.557 [1.395-4.687]) and more than 67 years (HRs: 4.404 [2.237-8.670], 5.113 [2.923-8.942]). For CSS/OS, the survival time of patients with localized stage was significantly longer than that of patients with regional stage (HRs: 1.530 [0.725-3.228], 1.548 [0.834-2.873]) and that of patients with distant stage (HRs: 1.706 [0.899-3.237], 2.101 [1.254-3.520]). Patients with surgery had more survival time than patients without surgery for CSS/OS (HRs: 2.861 [1.542-5.310], 2.103 [1.308-3.379]). All factors were further included to generate nomograms for CSS and OS. The C-indexes for the internal validation of OS and CSS prediction were 0.787 (95% confidence interval [CI]: 0.738-0.836) and 0.768 (95% CI: 0.717-0.819), respectively. Conclusions: Age, stage, and surgery were closely associated with prognosis in patients with BA, and this clinical model was a favorable tool to evaluate survival possibilities.

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Section: Discussionmentioning

confidence: 99%

Section: Epidemiological Analysis and Identification Of Prognostic Famentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Clinical Model of Bone Angiosarcoma Patients: A Population‐based Analysis of Epidemiology, Prognosis, and Treatment

Wang

Chen

Wang

2020

Orthopaedic Surgery

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“…It usually occurs in the first and second decades of life and mainly involves the long bones of the extremities, pelvis, and ribs. 1,2 Primary Ewing's sarcoma of the skull is very rare, occurring in only $1% of cases. 3,4 We describe here the clinical, neuroradiologic, and histopathologic features of a patient with primary Ewing's sarcoma of the skull and discuss the therapy for this type of tumor.…”

Section: Introductionmentioning

confidence: 99%

“…Long-term follow-up of larger numbers of patients is required to prove that Ewing's sarcoma of the skull bone has a different prognosis to this lesion in other locations, although case reports and retrospective series of cases strongly suggest this conclusion. 1,2,6 Conflict of Interest None declared.…”

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confidence: 98%

Entrapment of the Greater Occipital Nerve with Chronic Migraine and Severe Facial Pain: A Case Report

Son

2021

J Neurol Surg A Cent Eur Neurosurg

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Background and Objective Primary Ewing's sarcoma of the skull is a very rare malignant neoplasm, predominantly occurring in children and adolescents. We describe here the clinical, neuroradiologic, and histopathologic features of a patient with primary Ewing's sarcoma of the skull and discuss the standards of therapy for this type of tumor. Clinical Presentation This 18-year-old male patient presented with a primary Ewing's sarcoma of the skull, involving the dura of the frontal and parietal lobes of the left cerebral hemisphere. He was treated with gross total surgical excision of tumor, skull reconstruction, chemotherapy, and irradiation. Twelve years after the surgery, the patient has no evidence of local recurrence or distant metastases. Radical surgical excision of the primary tumor with safety margins is thought to play a role in the favorable clinical course. Conclusion The presented case is the longest surviving patient after treatment of primary Ewing's sarcoma of the skull bone. This rare type of tumor may allow better survival rates under adequate management than sarcoma elsewhere in the body.

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Soft Tissue and Bone Tumors of the Head and Neck

Domanski,

Gajdzis

2024

Diagnostic Procedures in Patients With Neck Masses

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Pediatric Ewing sarcoma of the head and neck: A retrospective survival analysis

Cited by 18 publications

References 13 publications

A Clinical Model of Bone Angiosarcoma Patients: A Population‐based Analysis of Epidemiology, Prognosis, and Treatment

A Clinical Model of Bone Angiosarcoma Patients: A Population‐based Analysis of Epidemiology, Prognosis, and Treatment

Entrapment of the Greater Occipital Nerve with Chronic Migraine and Severe Facial Pain: A Case Report

Soft Tissue and Bone Tumors of the Head and Neck

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