Pediatric Genitourinary Infections and Other Considerations

Stephanos, Kathleen; Bragg, Andrew F.

doi:10.1016/j.emc.2019.07.010

Cited by 2 publications

(1 citation statement)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By the age of seven, an estimated 7.8% of girls and 1.7% of boys have experienced at least one episode of UTI [3]. Its clinical presentation is variable, revealed by various pictures with a symptomatology all the more atypical as the child is younger [3][4][5], it is often associated with a vesico-urethral reflux or an obstructive uropathy, any urinary infection must be investigated, its essential risk is the occurrence of renal scars, sources of hypertension and renal failure [6]. The diagnosis is based on the detection of germs in the urine by the ECBU, the interpretation of whose microbiological results is sometimes delicate.…”

Section: Introductionmentioning

confidence: 99%

Ambulatory Management of Urinary Tract Infections in Children: Experience of the Pediatric Medical Emergency Department in Rabat

Ahmed¹,

Mekaoui²,

Dakhama³

et al. 2023

AJPR

View full text Add to dashboard Cite

The aim of the study is to describe the clinical epidemiological characteristics and bacteriological profile of UTIs in infants and children, to determine the main risk factors for the occurrence of UTIs, and to identify the causes of UTIs urinary tract infections, to compare the interest of CRP and let procalcitonin assays for the diagnosis of febrile urinary tract infections as well as the interest of imaging (renal scintigraphy and ultrasound of the urinary tree) in the diagnosis of febrile urinary tract infections. This observational study of a cohort of 169 patients (children aged more than 28 days, 119 girls and 40 boys) conducted in the pediatric emergency department of the children's hospital of the university hospital of Rabat over a period of 6 months. The diagnosis of UTIs is based on the detection of germs in the urine, either indirectly by urine dipstick or by urine culture. However, the interpretation of microbiological results can be tricky: an inappropriate urine collection technique, particularly in neonates and young children, is a pitfall that the clinician must take into account to avoid misdiagnosing UTI, usually by over-diagnosis. The location of high UTI involving the renal parenchyma or low UTI limited to the bladder, which determines the morbidity of the infection, the therapeutic management and the imaging work-up, remains a matter of debate. DMSA renal scintigraphy, the reference examination in the case of high UTI, cannot be recommended as a first-line examination because of its cost and the practical difficulties of performing it. Biological markers of inflammation (leucocytosis, CRP, procalcitonin) do not always allow the diagnosis of ANP to be made with certainty.

show abstract

Section: Introductionmentioning

confidence: 99%

Ambulatory Management of Urinary Tract Infections in Children: Experience of the Pediatric Medical Emergency Department in Rabat

Ahmed¹,

Mekaoui²,

Dakhama³

et al. 2023

AJPR

View full text Add to dashboard Cite

show abstract

Etiopathogenesis of reproductive tract infections and the emerging role of bitter taste receptors

Welcome

Jeremiah

Allagoa

et al. 2021

Asian Pacific Journal of Reproduction

View full text Add to dashboard Cite

Reproductive tract infections pose an immense public health concern worldwide as over 600 million new cases are recorded annually along with several complications, including infertility, ectopic pregnancy, preterm delivery, and neonatal death. Despite improved understanding of the mechanisms of pathogenic invasion, the etiopathogenesis of reproductive tract infections is yet to be completely understood. Recent data has suggested a critical role of bitter taste receptors of the reproductive tract in etiopathogenesis of reproductive tract infections. Here, we review the literature on current etiopathogenesis of reproductive tract infections and the role of bitter taste receptors of the reproductive tract in etiopathogenesis of reproductive tract infections. Emerging evidence suggests a critical role of microbiota disorder of the reproductive tract in reproductive tract infections. Several bacterial, protozoan parasitic, helminthic parasitic and viral pathogens have been identified as causative agents of reproductive tract infections. These pathogens subvert host defenses and activate specific architectural units of the uroepithelium such as Toll-like receptors, which recognize conserved motifs on the pathogens. The activated Toll-like receptors mediate downstream signaling, stimulating nuclear factor-κB, which in turn activates the production of proinflammatory cytokines. This pathway is also associated with recruitment of immunocytes to the site of aggression and release of proteinases, which drive tissue damage in the reproductive tract. Defects in detection of pathogenic components by the bitter taste receptors of the reproductive tract may play a critical role in the etiopathogenesis of reproductive tract infections. This review provides important information for identification of novel frontiers for the treatment of reproductive tract infections.

show abstract

Pediatric Genitourinary Infections and Other Considerations

Cited by 2 publications

References 58 publications

Ambulatory Management of Urinary Tract Infections in Children: Experience of the Pediatric Medical Emergency Department in Rabat

Ambulatory Management of Urinary Tract Infections in Children: Experience of the Pediatric Medical Emergency Department in Rabat

Etiopathogenesis of reproductive tract infections and the emerging role of bitter taste receptors

Contact Info

Product

Resources

About