Pediatric granular cell tumor of the tracheobronchial tree

Finck, Christine; Moront, Matthew; Newton, Christopher; Timmapuri, Shaheen J.; Lyons, Jane; Rozans, Marta K.; Chadarévian, Jean‐Pierre de; Halligan, Gregory E.

doi:10.1016/j.jpedsurg.2007.11.024

Cited by 6 publications

(8 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is important to note that, in contrast with earlier studies, most patients (n = 70; 90%) routinely underwent CT scans, which allows the early detection and better definition of small pulmonary lumps, consistent with the current algorithm for recurrent respiratory symptoms in pediatric populations …”

Section: Discussionmentioning

confidence: 63%

“…Bronchoscopy played a fundamental role in the diagnostic workup because adequate biopsy specimens could be obtained to perform accurate diagnosis and appropriately schedule the treatment plan . In our series, bronchoscopy was reserved for biopsy (n = 52 per 66, 79%), and endoscopic resections were attempted only in selected cases (n = 17 per 77; 16%).…”

Section: Discussionmentioning

confidence: 99%

“…To date, most of the literature comprises case reports or case series that mainly focus on each histological subtype …”

Section: Introductionmentioning

confidence: 99%

“…1,[4][5][6]8,10,17 To date, most of the literature comprises case reports or case series that mainly focus on each histological subtype. 3,[6][7][8][9][10][12][13][14][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] Because specific pediatric oncologic guidelines on preoperative workup, treatment, and follow-up are still lacking, the International Network of Pediatric Airway Teams (INPAT) has coordinated a large international cohort of PTT in children, including the entire Italian cohort collected by the Tumori Rari in Età Pediatrica (TREP) (Rare Tumors in Children), with a total of 14 institutions to provide a complete overview with regard to clinical presentation, diagnostic assessment, histological findings, and outcomes. Particular attention has been given to identifying the main prognostic factors, possibly influencing outcome and carefully evaluating treatment modalities.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Pediatric airway tumors: A report from the International Network of Pediatric Airway Teams (INPAT)

et al. 2019

View full text Add to dashboard Cite

Objective Primary tracheobronchial tumors (PTTs) are rare heterogeneous lesions arising from any part of the tracheobronchial tree. Nonspecific symptoms may lead to delayed diagnosis that requires more aggressive surgical treatment. An analysis of cases collected by the International Network of Pediatric Airway Team was undertaken to ensure proper insight into the behavior and management of PTTs. Methods Patients <18 years of age with a histological confirmation of PTT diagnosed from 2000 to 2015 were included in this multicenter international retrospective study. Medical records, treatment modalities, and outcomes were analyzed. The patient presentation, tumor management, and clinical course were compared between malignant and benign histotypes. Clinical and surgical variables that might influence event‐free survival were considered. Results Among the 78 children identified, PTTs were more likely to be malignant than benign; bronchial carcinoid tumor (n = 31; 40%) was the most common histological subtype, followed by inflammatory myofibroblastic tumor (n = 19; 25%) and mucoepidermoid carcinoma (n = 15; 19%). Regarding symptoms at presentation, wheezing (P = 0.001) and dyspnea (P = 0.03) were more often associated with benign growth, whereas hemoptysis was more frequently associated with malignancy (P = 0.042). Factors that significantly worsened event‐free survival were age at diagnosis earlier than 112 months (P = 0.0035) and duration of symptoms lasting more than 2 months (P = 0.0029). Conclusion The results of this international study provide important information regarding the clinical presentation, diagnostic workup, and treatment of PTTs in children, casting new light on the biological behavior of PTTs to ensure appropriate treatments. Level of Evidence NA Laryngoscope, 130:E243–E251, 2020

show abstract

Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

“…To date, most of the literature comprises case reports or case series that mainly focus on each histological subtype …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pediatric airway tumors: A report from the International Network of Pediatric Airway Teams (INPAT)

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Approximately half of all cases originates in the head and neck, with 10% of these one having a laryngeal involvement (12,13). In children, surgical resection should be considered because of recurrent obstructive symptoms, although malignant transformation has never been documented (14).…”

Section: Benign Tumorsmentioning

confidence: 99%

Tracheal and bronchial tumors

Varela¹,

Pio²,

Brandigi³

et al. 2016

J. Thorac. Dis.

View full text Add to dashboard Cite

Although primary tracheobronchial tumors are extremely rare in children, recurrent respiratory symptoms resistant to conventional therapy require further investigations to exclude possible malignant obstructive causes. As the matter of fact, early diagnosis may allow minimally invasive surgeries, improving the standard of living and the globally survival rate. The aim of this article is to provide an overview of diagnosis and management of tracheobronchial tumors in the early age, since only few reports are reported in the worldwide literature.

show abstract