Pediatric Guillain-Barré Syndrome in a 30-Year Nationwide Cohort

Levison, Lotte Sahin; Thomsen, Reimar Wernich; Markvardsen, Lars Kjøbsted; Christensen, Diana Hedevang; Sindrup, Søren Hein; Andersen, Henning

doi:10.1016/j.pediatrneurol.2020.01.017

Cited by 29 publications

(42 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In children, the incidence rate is lower, approx. 0.69 per 100,000 person per year [24]. Referring to research conducted in Europe, a populationbased study pointed out an incidence rate of 1.2-1.9 per 100,000 people [25].…”

Section: Discussionmentioning

confidence: 99%

Facial Diplegia—Complication or Manifestation of SARS-CoV-2 Infection? A Case Report and Systemic Literature Review

et al. 2021

View full text Add to dashboard Cite

Since the outbreak of the new coronavirus, healthcare systems around the world have witnessed not only COVID-19 symptoms but also long-term complications of the aforementioned, including neurological problems. We report a clinical case of an adult patient with bilateral facial nerve palsy and progressive ascending paresis of the limbs after contracting the novel coronavirus (COVID-19). Additionally, the systematic review aimed to identify and summarize specific clinical features, outcomes and complications of the studies focusing on bilateral facial diplegia as a sequela of COVID-19 infection. The total number of analyzed patients was 15. Only one patient was diagnosed with isolated bilateral palsy; the rest had Guillain-Barré Syndrome (GBS). With one exception, all the presented cases had favorable outcomes, with facial palsy recovery from slight to almost complete. In patients with a confirmed COVID-19 diagnosis, bilateral facial palsy may be an isolated symptom as well as a variant of GBS. Symptoms of cranial nerve damage during a COVID-19 infection may explain the appearance of facial nerve damage. In order to clarify the spectrum of neurological manifestations and a causal relation between SARS-CoV-2, COVID-19 vaccination and neurological symptoms, direct attention towards the study of this virus is crucial. It seems reasonable to recognize human coronavirus as another potential GBS trigger.

show abstract

Section: Discussionmentioning

confidence: 99%

Facial Diplegia—Complication or Manifestation of SARS-CoV-2 Infection? A Case Report and Systemic Literature Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The most common infectious triggers are minor respiratory illness, but gastrointestinal illnesses, other viral syndromes and immunizations have also been associated with GBS. 2 Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), originated in Wuhan China in late 2019 and rapidly spread around the world causing a pandemic of novel coronavirus disease 2019 (COVID-19). The majority of pediatric disease is asymptomatic, but the common clinical presentations of COVID-19 are fever, malaise, and respiratory symptoms, which can range from mild cough to severe pneumonia, and occasional gastrointestinal symptoms.…”

Section: Introductionmentioning

confidence: 99%

Guillain-Barré Syndrome in a Child With COVID-19 Infection

Curtis¹,

Bhumbra

Felker³

et al. 2021

Pediatrics

View full text Add to dashboard Cite

This is a prepublication version of an article that has undergone peer review and been accepted for publication but is not the final version of record. This paper may be cited using the DOI and date of access. This paper may contain information that has errors in facts, figures, and statements, and will be corrected in the final published version. The journal is providing an early version of this article to expedite access to this information. The American Academy of Pediatrics, the editors, and authors are not responsible for inaccurate information and data described in this version.

show abstract

“…12 Several investigations on the characteristics of children with GBS, however, revealed that male outnumbered females (54-58 %: 46-42 %). [13][14][15][16][17][18] The patients in this study were predominantly 10-14 years old (43.9%); study by Levinson in Denmark and Sandip in India both found the same result. GBS was most commonly diagnosed in children under the age of ten years old.…”

Section: Discussionmentioning

confidence: 67%

Profile Of Children With Guillan Barre Syndrome In RSUP Haji Adam Malik Medan: Events In 5 Years

H¹,

Dimyati²,

Hasibuan³

2021

IJRP

View full text Add to dashboard Cite

Background : Guillain-Barré syndrome (GBS) is an acute demyelinating disease of the peripheral nervous system characterized clinically by flaccid paralysis. The mortality rate in children is about 3-5%. Early diagnosis and therapy important for patient's prognosis. Objective : The aim of this study was to acquaint the profile of children with Guillain-Barré syndrome at the RSUP HAM Medan Hospital from 2016 to 2020. Methods : This study is a descriptive study with a retrospective design. The population and sample with total sampling of the children with GBS diagnosed at the HAM Medan Hospital recorded in the medical record from January 2016 to December 2020. The data were analyzed univariately and presented with a frequency distribution. Results: From this study, 41 children with GBS were found. There were 18 children (43.9%) with age between 10-14 year (female was 22 people (53.7%). Based on the Brighton Criteria for GBS children, most of the children was on level 2 that were 35 people (85 ,4%). From the results of the EMG (Electromyography) examination in GBS children, 24 people (58.5%). had the most types of GBS were Acute Motor Axonal Neuropathy (AMAN). There was no cytoalbumin dissociation was found on CSF analysis. Mostly 28 people had supportive therapy, that was the most used type of therapy. The disability scale shows that children who can walk with the help of a cane or supporting equipment (disability scale 3) was 26 people (63.4%). Based on the length of stay in the hospital, 26 children (63.4%) were treated for 8-14 days. Conclusion: Majority the case of GBS in the RSUP HAM Medan was similar previous studies. Our results can be used as baseline data for understanding the characteristics of GBS in Indonesia.

show abstract

Pediatric Guillain-Barré Syndrome in a 30-Year Nationwide Cohort

Cited by 29 publications

References 41 publications

Facial Diplegia—Complication or Manifestation of SARS-CoV-2 Infection? A Case Report and Systemic Literature Review

Facial Diplegia—Complication or Manifestation of SARS-CoV-2 Infection? A Case Report and Systemic Literature Review

Guillain-Barré Syndrome in a Child With COVID-19 Infection

Profile Of Children With Guillan Barre Syndrome In RSUP Haji Adam Malik Medan: Events In 5 Years

Contact Info

Product

Resources

About