Pediatric heart transplantation in infants and small children under 3 years of age: Single center experience – “Early and long-term results”

Rosenthal, Laura L.; Ulrich, Sarah; Zimmerling, Linda; Brenner, Paolo; Müller, Christoph; Michel, Sebastian; Hörer, Jürgen; Netz, Heinrich; Haas, Nikolaus A.; Hagl, Christian

doi:10.1016/j.ijcard.2022.04.002

Cited by 5 publications

(4 citation statements)

References 30 publications

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“…This surgical treatment is commonly known as “operation”. The purpose is to treat or diagnose diseases to improve the body’s function and shape, such as removing diseased tissues ( 1 , 2 ), repairing injuries ( 3 , 4 ), and organ transplantation ( 5 , 6 ). Early surgery is limited to cutting and suturing on the body surface by simple manual methods such as abscess drainage, tumor resection, and trauma suturing.…”

Section: Introductionmentioning

confidence: 99%

Model-Based Computational Analysis on the Effectiveness of Enhanced Recovery after Surgery in the Operating Room with Nursing

Xie

et al. 2022

Front. Surg.

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ObjectiveIn order to better understand the relative surgical process, this work used a model-based computational analysis on the effectiveness of enhanced recovery after surgery (ERAS) in the operating room with nursing.MethodsA total of 360 surgical patients in the First Affiliated Hospital, Sun Yat-sen University, from the period June 2020 to March 2021, were randomly divided into two groups, namely, observation group and control group, with 180 cases in each group. Routine nursing was used in the control group, while ERAS was implemented in the observation group from the point of view of four aspects, namely, preoperative visit, intraoperative cooperation, postoperative return visit, and psychological intervention.ResultsPostoperative complications, average hospital stay, nursing satisfaction, and postoperative quality of life in the observation group were significantly better than those in the control group (all p < 0.05).ConclusionThe application of ERAS for surgical patients can enhance team awareness, optimize the process of cooperation, reduce surgical complications and improve nursing quality, and prognosis, and it is worth popularizing in the operating room.

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Section: Introductionmentioning

confidence: 99%

Model-Based Computational Analysis on the Effectiveness of Enhanced Recovery after Surgery in the Operating Room with Nursing

Xie

et al. 2022

Front. Surg.

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“…These findings are similar to what has been demonstrated in other studies that patients undergoing heart transplant at < 3mo of age or with single-ventricle physiology have higher rates of early mortality and thus, less time spent out of the hospital. 18 Additionally, patients undergoing total anomalous pulmonary venous return repair are shown to have poor long-term survival, further demonstrating this to be a high-risk population that may require more healthcare resources. 19 Multivariable analysis identified risk factors associated with fewer days alive and out of hospital in the first year of life including index operation of hybrid Norwood or heart transplant.…”

Section: Discussionmentioning

confidence: 99%

Days alive and out of hospital for children born with single-ventricle heart disease

Medina,

Prabhu,

Alderete

et al. 2024

Cardiol Young

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Background: This study describes the illness burden in the first year of life for children with single-ventricle heart disease, using the metric of days alive and out of hospital to characterize morbidity and mortality. Methods: This is a retrospective single-centre study of single-ventricle patients born between 2005 and 2021 who had their initial operation performed at our institution. Patient demographics, anatomical details, and hospitalizations were extracted from our institutional single-ventricle database. Days alive and out of hospital were calculated by subtracting the number of days hospitalized from number of days alive during the first year of life. A multivariable linear regression with stepwise variable selection was used to determine independent risk factors associated with fewer days alive and out of hospital. Results: In total, 437 patients were included. Overall median number of days alive and out of hospital in the first year of life for single-ventricle patients was 278 days (interquartile range 157–319 days). In a multivariable analysis, low birth weight (<2.5kg) (b = −37.55, p = 0.01), presence of a dominant right ventricle (b = −31.05, p = 0.01), moderate-severe dominant atrioventricular valve regurgitation at birth (b = −37.65, p < 0.05), index hybrid Norwood operation (b = −138.73, p < 0.01), or index heart transplant (b = −158.41, p < 0.01) were all independently associated with fewer days alive and out of hospital. Conclusions: Children with single-ventricle heart defects have significant illness burden in the first year of life. Identifying risk factors associated with fewer days alive and out of hospital may aid in counselling families regarding expectations and patient prognosis.

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“…In group 1, mean age was 15 ± 16 years, mean BMI was 18 ± 4 per kg/cm 2 and mean follow up time was 15 ± 9 years; in group 2, mean age was 14 ± 12 years, mean BMI was 16 ± 4 per kg/cm 2 and mean follow up time was 7 ± 6 years. The follow‐up time was ≥1 year post‐transplant, and the overall median follow‐up time was 13 years 6–19 …”

Section: Methodsmentioning

confidence: 99%

“…The Impact of the operative technique on mid-and long-term results following paediatric heart transplantation follow-up time was ≥1 year post-transplant, and the overall median follow-up time was 13 years. [6][7][8][9][10][11][12][13][14][15][16][17][18][19] The following patients were excluded: one patient after pHTx was lost to follow-up, heart and lung transplantation, ABO-incompatible heart transplantation, combined heart and liver or heart and kidney transplantation and re-transplantation after primary heart transplantation in paediatric patients. Patient's data are included and studied in this actual study until re-HTx time.…”

Section: Study Population and Study Designmentioning

confidence: 99%

Impact of the operative technique on mid‐ and long‐term results following paediatric heart transplantation

Rosenthal,

Grinninger,

Pozza

et al. 2024

ESC Heart Failure

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AimsThe aim of this study is to evaluate and compare the impact of the bicaval technique versus the biatrial technique (by Lower and Shumway) in paediatric heart transplant patients. Only a few studies investigate this matter regarding the long‐term outcome after paediatric heart transplantation. We compared the two surgical methods regarding survival, the necessity of pacemaker implantation.Methods and resultsAll 134 patients (aged <18 years) – (group‐1) biatrial (n = 84), versus (group‐2) bicaval (n = 50), who underwent heart transplantation between October 1988 and December 2021, were analysed. Freedom from events were estimated using the Kaplan–Meier method. Potential differences were analysed using the log rank test and Cox proportional hazard models. Mean ± standard deviation: Bypass time (per minutes) was higher in the group 1 as compared with group 2 (P = 0.050). Survival was not significantly different (P = 0.604) in either groups. Eighteen patients required permanent pacemaker implantation in the group 1 and only one patient required it in the group 2 (P = 0.001).ConclusionsPaediatric heart transplantation using bicaval technique results similar long‐term survival compared with the biatrial technique. The incidence of atrial rhythm disorders was significantly higher in the biatrial group, requiring a higher frequency of pacemaker implantation in this group. As a results, the bicaval technique has replaced the biatrial technique in our centre.

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Pediatric heart transplantation in infants and small children under 3 years of age: Single center experience – “Early and long-term results”

Cited by 5 publications

References 30 publications

Model-Based Computational Analysis on the Effectiveness of Enhanced Recovery after Surgery in the Operating Room with Nursing

Model-Based Computational Analysis on the Effectiveness of Enhanced Recovery after Surgery in the Operating Room with Nursing

Days alive and out of hospital for children born with single-ventricle heart disease

Impact of the operative technique on mid‐ and long‐term results following paediatric heart transplantation

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