Pediatric Highlights From the Extracorporeal Life Support Organization Registry: 2017–2022

O’Neil, Erika R.; Guner, Yigit; Anders, Marc M.; Priest, John; Friedman, Matthew L.; Raman, Lakshmi; Di Nardo, Matteo; Alexander, Peta; Tonna, Joseph E.; Rycus, Peter; Thiagarajan, Ravi R.; Barbaro, Ryan; Sandhu, Hitesh S.

doi:10.1097/mat.0000000000002078

ASAIO Journal

2023

DOI: 10.1097/mat.0000000000002078

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Pediatric Highlights From the Extracorporeal Life Support Organization Registry: 2017–2022

Erika R. O’Neil,

Yigit Guner,

Marc M. Anders

et al.

Abstract: The Extracorporeal Life Support Organization (ELSO) registry which collects data from hundreds of participating centers supports research in ECMO to help improve patient outcomes. The ELSO Scientific Oversight Committee, an international and diverse group of ECMOlogists (https://www.elso.org/registry/socmembers.aspx), selected the most impactful and innovative research articles on pediatric ECMO emerging from ELSO data. Here they present brief highlights of these publications.

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Cited by 2 publications

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Research progress on the pathogenesis of AKI complicated by ECMO

Sun,

Yao,

et al. 2024

Clin Exp Nephrol

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Background Extracorporeal membrane oxygenation (ECMO) stands as a pivotal intervention for patients grappling with cardiopulmonary insufficiency. However, alongside its therapeutic benefits, ECMO carries the risk of complications, with acute kidney injury (AKI) emerging as a significant concern. The precise pathophysiological underpinnings of AKI in the context of ECMO remain incompletely elucidated. Methods A comprehensive literature review was conducted to explore the epidemiology and pathophysiological mechanisms underlying the utilization of ECMO in the management of AKI. Results ECMO initiates a multifaceted cascade of inflammatory reactions, encompassing complement activation, endothelial dysfunction, white blood cell activation, and cytokine release. Furthermore, factors such as renal hypoperfusion, ischemia–reperfusion injury, hemolysis, and fluid overload exacerbate AKI. Specifically, veno-arterial ECMO (VA-ECMO) may directly induce renal hypoperfusion, whereas veno-venous ECMO (VV-ECMO) predominantly impacts pulmonary function, indirectly influencing renal function. Conclusion While ECMO offers significant therapeutic advantages, AKI persists as a potentially fatal complication. A thorough comprehension of the pathogenesis underlying ECMO-associated AKI is imperative for effective prevention and management strategies. Moreover, additional research is warranted to delineate the incidence of AKI secondary to ECMO and to refine clinical approaches accordingly.

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Research progress on the pathogenesis of AKI complicated by ECMO

Sun,

Yao,

et al. 2024

Clin Exp Nephrol

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Best Practices for Vessel Management in Pediatric Extracorporeal Membrane Oxygenation Cannulation, Decannulation, and Follow-up: A Narrative Review

McDermott,

Moursi,

Tomita

et al. 2025

Journal of Pediatric Surgery

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Pediatric Highlights From the Extracorporeal Life Support Organization Registry: 2017–2022

Cited by 2 publications

References 29 publications

Research progress on the pathogenesis of AKI complicated by ECMO

Research progress on the pathogenesis of AKI complicated by ECMO

Best Practices for Vessel Management in Pediatric Extracorporeal Membrane Oxygenation Cannulation, Decannulation, and Follow-up: A Narrative Review

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