Pediatric Hypereosinophilia: Characteristics, Clinical Manifestations, and Diagnoses

Burris, Dara; Rosenberg, Chen E.; Schwartz, Justin T.; Yin, Zhang; Eby, Michael D.; Abonia, J. Pablo; Fulkerson, Patricia C.

doi:10.1016/j.jaip.2019.05.011

Cited by 33 publications

(46 citation statements)

References 21 publications

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“…Drug-related eosinophilia was reported as the most common cause of eosinophilia (24.5%) in a previous study (8). Besides, in a pediatric cohort, 2.8% of patients had DHRs as a cause of eosinophilia (21). Similarly, in our study, only three patients had DHRs.…”

Section: Discussionsupporting

confidence: 69%

Characterization of Consultations Requested for Patients With Elevated Blood Eosinophils: A Tertiary Immunology and Allergy Clinic Experience

Beyaz

Sözener

SOYYİĞİT

2022

jmed

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Objective: Blood eosinophilia has become a common laboratory abnormality and its characterization poses a dilemma for physicians. As a result, physicians often consult specialists in immunology and allergy in order to evaluate patients with high eosinophils, with the general assumption of an underlying allergic or immunologic cause. However, there is little data in the literature regarding consultations requested from immunology and allergy clinics because of eosinophilia. This study aimed to evaluate the clinical and demographic characteristics of patients who were consulted to the allergy clinic because of eosinophilia and detail the etiologies of eosinophilia. Methods:The medical records of 1366 patients consulted to the allergy clinic were evaluated retrospectively, and the data of 143 patients who were consulted for eosinophilia were investigated.

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Section: Discussionsupporting

confidence: 69%

Characterization of Consultations Requested for Patients With Elevated Blood Eosinophils: A Tertiary Immunology and Allergy Clinic Experience

Beyaz

Sözener

SOYYİĞİT

2022

jmed

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“…Peripheral eosinophilia was defined by an eosinophil cell count above 500 cells/µL. Therefore, it was classified as mild (500–1500 cells/µL), moderate (1500–5000 cells/µL), or severe (>5000 cells/µL), according to eosinophil levels [ 33 ].…”

Section: Methodsmentioning

confidence: 99%

Strongyloidiasis in Children Outside the Tropics: Do We Need to Increase Awareness?

et al. 2021

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Strongyloidiasis belongs to the group of neglected tropical diseases, due to diagnostic difficulties and the lack of systematic screening. Studies on strongyloidiasis prevalence are often heterogenous and mainly performed in adults in endemic countries. We retrospectively enrolled 2633 children referred to a tertiary care hospital in Italy between 2009 and 2020 and tested for S. stercoralis infection. Sixty-one (2.3%) had a positive serology and for 55 of them, clinical and epidemiological information were available. Thirteen cases (24%) were diagnosed in Italian children without history residency or travel to foreign countries, while the remaining were internationally adopted or migrant children. Seropositive patients were mostly asymptomatic, and often eosinophilia was the only sign of strongyloidiasis. Sero-reactivity to Toxocara canis was found in 1/3 of patients. Ivermectin was used in 37 (75.5%) treated patients. A significant reduction of eosinophil levels and IgG titer was seen after treatment. Our study confirms that strongyloidiasis is usually asymptomatic in children. However, due to the ability of the parasite to cause a life-long infection together with the risk of a severe form in case of immunosuppression, it is important to identify and treat infected children. Special consideration should be reserved to high-risk groups, such as immigrants and international adoptees, where screening for S. stercoralis is indicated. However, the study highlights that sporadic cases of autochthonous strongyloidiasis in Italy may occur. Therefore, pediatricians should be aware of this condition, which is often under-recognized.

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“…The number of circulating eosinophils is strictly regulated. A significant increase can cause adverse reactions, such as those seen in gastrointestinal eosinophilic conditions and severe inflammatory responses during helminthic infection [4][5][6][7][8][9][10][11].…”

Section: Course After Dischargementioning

confidence: 99%

A Four-Year Old with Severe Idiopathic Hypereosinophilia

Taranish¹,

Sehgal²,

Zaid-Kaylani³

et al. 2022

jrdod

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Abstract Background: Background: Eosinophils are granulocytes that have a role in allergy and immune defense reactions. They represent a small percentage of circulating WBCs, and marked increases in their numbers can cause significant detrimental effects. Hypereosinophilia can be allergic, inflammatory, infectious, or malignant in origin. Hypereosinophilic syndrome is an uncommon disorder of eosinophils that can cause significant end-organ damage (Chen YY, Khoury P, Ware JM, et al.) Case presentation: A 4-year-old female presented with fever and abdominal pain and was found to have cervical and axillary lymphadenopathy spontaneously resolved and with an incidental finding of hypereosinophilia. The patient had an extensive workup, which was negative for common allergic, infectious, inflammatory, and neoplastic etiologies. She continued to show clinical and laboratory improvement and was discharged with the diagnosis of the idiopathic hypereosinophilic syndrome after the exclusion of other etiologies. Her follow-up after discharge showed improvement in eosinophil counts, and she is still being monitored. Given the lack of clear etiology and end-organ damage, she meets the definition of hypereosinophilia of undetermined significance. However, a gastroenterology workup is still considered as future symptoms evolve. Conclusion: Hypereosinophilia is a relatively uncommon disorder in the pediatric population that could be asymptomatic and discovered incidentally through laboratory workup; however, if it goes unrecognized, it can cause significant morbidity secondary to end-organ damage. Keywords: absolute eosinophil count, eosinophilia, hypereosinophilic syndrome.

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Pediatric Hypereosinophilia: Characteristics, Clinical Manifestations, and Diagnoses

Cited by 33 publications

References 21 publications

Characterization of Consultations Requested for Patients With Elevated Blood Eosinophils: A Tertiary Immunology and Allergy Clinic Experience

Characterization of Consultations Requested for Patients With Elevated Blood Eosinophils: A Tertiary Immunology and Allergy Clinic Experience

Strongyloidiasis in Children Outside the Tropics: Do We Need to Increase Awareness?

A Four-Year Old with Severe Idiopathic Hypereosinophilia

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