Pediatric<i>vs</i>adult pulmonary tuberculosis: A retrospective computed tomography study

Veedu, Prasad Thotton; Bhalla, Ashu Seith; Vishnubhatla, Sreenivas; Kabra, Sushil Kumar; Arora, Aashima; Singh, Divya; Gupta, Arun Kumar

doi:10.5409/wjcp.v2.i4.70

Cited by 25 publications

(27 citation statements)

References 20 publications

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“…End-stage TB may cause complete destruction of the lung parenchyma resulting from a combination of parenchymal and airway involvement. Contrary to the previous notions, recent studies[ 26 ] suggest that children and adolescents are also equally prone to develop destructive lung changes with severe sequelae, similar to PPT. The similar location and morphology of parenchymal changes observed in children blurs the distinction between primary and reactivation TB.…”

Section: Primary and Post-primary Tbmentioning

confidence: 83%

Chest tuberculosis: Radiological review and imaging recommendations

Bhalla

Goyal

Guleria

et al. 2015

Indian Journal of Radiology and Imaging

154

112

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Chest tuberculosis (CTB) is a widespread problem, especially in our country where it is one of the leading causes of mortality. The article reviews the imaging findings in CTB on various modalities. We also attempt to categorize the findings into those definitive for active TB, indeterminate for disease activity, and those indicating healed TB. Though various radiological modalities are widely used in evaluation of such patients, no imaging guidelines exist for the use of these modalities in diagnosis and follow-up. Consequently, imaging is not optimally utilized and patients are often unnecessarily subjected to repeated CT examinations, which is undesirable. Based on the available literature and our experience, we propose certain recommendations delineating the role of imaging in the diagnosis and follow-up of such patients. The authors recognize that this is an evolving field and there may be future revisions depending on emergence of new evidence.

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Section: Primary and Post-primary Tbmentioning

confidence: 83%

Chest tuberculosis: Radiological review and imaging recommendations

Bhalla

Goyal

Guleria

et al. 2015

Indian Journal of Radiology and Imaging

154

112

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“…In 2011, half a million children (0-14 years) developed TB, and 64,000 children died from the disease. Risk of TB infection in children is 2-5% in developing countries (Veedu et al, 2013). At-risk groups in children include those of lower socioeconomic status, being in an immunecompromised state, having a history of incarceration, or living in countries with high TB incidence (Yousef et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic values of microRNA-31 in peripheral blood mononuclear cells for pediatric pulmonary tuberculosis in Chinese patients

Jx¹,

Xu²,

Han³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We investigated the diagnostic values of microRNA-31 in peripheral blood mononuclear cells (PBMCs) for pediatric pulmonary tuberculosis in Chinese patients. Sixty-five children with TB were selected for this study, which was conducted at the Department of Infectious Diseases People's Hospital of Laiwu City between December 2013 and December 2014. Sixty healthy children, selected in parallel, served as the control group. Real-time PCR was used to detect miR-31 expression in PBMCs. Serum levels of IL-6, TNF-α, NF-κB, and IFN-γ was detected by ELISA. ROC curve was employed to evaluate the diagnostic value of miR-31 in pediatric TB. Results show that expression of miRNA-31 in pediatric TB patients was significantly lower than that in normal children (0.48 ± 0.15 vs 1.23 ± 0.36, P < 0.05). By contrast, serum levels of the innate immune response cytokines, IL-6, TNF-α, NF-κB, and IFN-γ, were significantly higher in pediatric TB patients compared with normal children (P < 0.05). Furthermore, miRNA-31 expression was negatively correlated with serum levels of IL-6 (t = 69.91, P < 0.001), TNF-α (t = 10.96, P < 0.001), NF-κB (t = 39.94, P < 0.001), and IFN -γ (t = 37.94, P < 0.001). The cut-off threshold of miR-31 for pediatric TB diagnosis is 0.835 with a sensitivity of 98.5% and a (2015) specificity of 86.7%. Therefore, miR-31 has the potential to be a diagnostic marker in pediatric TB patients.

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“…Etkilenmiş bireylerin yaklaşık %5'inde, immün mekanizmalarının zayıflaması halinde ilk enfeksiyonu takip eden yıllarda uykuda olan basillerin endojen reaktivasyonu gerçekleşir ve postprimer TB denilen durum ortaya çıkar (18). Nadiren, ekzojen basili kaynaklı reenfeksiyon sebebiyle de postprimer TB ortaya çıkabilir (19). Çocuklardaki çoğu TB olgusu primer enfeksiyona bağlıdır (19).…”

Section: İstatistiksel Analizunclassified

“…Nadiren, ekzojen basili kaynaklı reenfeksiyon sebebiyle de postprimer TB ortaya çıkabilir (19). Çocuklardaki çoğu TB olgusu primer enfeksiyona bağlıdır (19). Fokal parankimal lezyon ile mediastinal veya hiler lenfadenopati radyolojik incelemeler ile tespit edilen en yaygın bulgudur.…”

Section: İstatistiksel Analizunclassified

Çocukluk Çağı Akciğer Tüberkülozu Tanısında Bilgisayarlı Tomografinin Yeri

Kaplan¹,

Akan²,

Dalgıç³

et al. 2019

J Pediatr Inf

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Bu çalışmanın amacı, çocukluk çağı akciğer tüberkülozu tanısında spesifik bilgisayarlı tomografi (BT) bulgularını tanımlamaktır. Gereç ve Yöntemler: Çalışmaya tüberküloz şüphesi olan 57 çocuk hasta dahil edildi. Toraks BT görüntüleri iki radyolog tarafından değerlendirildi. On yedi hasta kültür pozitifliği ile (mide açlık suyu, plevral sıvı, biyopsi veya bronkoalveoler lavaj örnekleri), 20 hasta ise klinik olarak tüberküloz tanısı aldı. Değerlendirilen kriterler lenf nodu büyümesi (> 1 cm), kalsifiye lenf nodları, konsolidasyon, kavitasyon, bronşiyal dallarda belirginleşme, plevral efüzyon, plevral kalınlaşma, ampiyem ve atelektazi olarak belirlendi. Tüberküloz hastaları (grup A) ve tüberküloz olmayan hastalar (grup B) arasındaki farklar Fisher exact testi kullanılarak analiz edildi. Bulgular: Lenf nodu büyümesi (> 1 cm), grup B'ye (5/20) kıyasla grup A'da (27/37) anlamlı olarak daha fazla bulundu (p< 0.01). B grubunda konsolidasyon (11/20), grup A'ya (7/37) kıyasla anlamlı olarak daha sık görüldü (p< 0.01). En büyük çapı > 1 cm olan lenf nodu büyümesinin duyarlılık ve özgüllüğü sırasıyla %73 ve %75 idi. Grup A'daki hastaların %43.2 (n= 16)'sinde plevral efüzyon, %40.5 (n= 15)'inde atelektazi, %18.9 (n= 7)'unda plevral kalınlaşma, %16.2 (n= 6)'sinde bronşiyal dallarda belirginleşme, %18.9 (n= 7)'unda konsolidasyon ve %13.5 (n= 5)'inde kalsifiye lenf nodları mevcuttu. B grubundaki hastaların ise %40 (n= 8)'ında plevral efüzyon, %35 (n= 7)'inde atelektazi, %20 (n= 4)'sinde plevral kalınlaşma, %20 (n= 4)'sinde ampiyem ve %15 (n= 3)'inde bronşiyal dallarda belirginleşme mevcuttu. Bu farklılıklar anlamlı değildi.

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Pediatricvsadult pulmonary tuberculosis: A retrospective computed tomography study

Abstract: Pediatric chest tuberculosis can have severe parenchymal lesions and nodal involvement similar to adults. The destructive lung changes observed in children needs immediate attention in view of the longer life span they have and hence in formulating optimal treatment strategies.

Cited by 25 publications

References 20 publications

Chest tuberculosis: Radiological review and imaging recommendations

Chest tuberculosis: Radiological review and imaging recommendations

Diagnostic values of microRNA-31 in peripheral blood mononuclear cells for pediatric pulmonary tuberculosis in Chinese patients

Çocukluk Çağı Akciğer Tüberkülozu Tanısında Bilgisayarlı Tomografinin Yeri

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