Pediatric Infectious Endophthalmitis

Zhang, Meng; Xu, Gezhi; Jiang, Rui; Ni, Yingqin; Wang, Keyan; Gu, Ruiping; Ding, Xinyi

doi:10.4103/0366-6999.195473

Cited by 20 publications

(16 citation statements)

References 30 publications

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“…We observed an increase in the proportion of Gram-positive bacterial infections, while those of Gram-negative bacilli and fungal infections decreased-albeit not significantly-between 2010-2014 and 2015-2018. Most previous studies reported that coagulase-negative staphylococci were the dominant pathogens [14,25,35]. However, we found that Streptococcus was the most prevalent isolate, followed by coagulase-negative staphylococci.…”

Section: Discussioncontrasting

confidence: 45%

“…Most previous studies reported that coagulase-negative staphylococci were the dominant pathogens [ 14 , 25 , 35 ]. However, we found that Streptococcus was the most prevalent isolate, followed by coagulase-negative staphylococci.…”

Section: Discussionmentioning

confidence: 99%

“…Among these, the sample sizes in most studies were small, with an even smaller number culture-positive cases, thereby providing limited information for clinical practice [11][12][13]. Zhang and colleagues reported the etiology and microorganism spectrum of 271 pediatric endophthalmitis cases in eastern China, of which 147 cases were culture positive; yet antibiotic susceptibility was not provided [14]. Information on antibiotic susceptibilities of endophthalmitis in children is critical for guiding empiric antibiotic treatment.…”

Section: Introductionmentioning

confidence: 99%

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Etiology, microbiological isolates, and antibiotic susceptibilities in culture-proven pediatric endophthalmitis: a 9-year review

Yang

Lin

et al. 2020

Graefes Arch Clin Exp Ophthalmol

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Purpose To analyze the etiology, microbiological isolates, and antibiotic susceptibilities of endophthalmitis in pediatric patients. Methods Patients aged < 18 years with culture-positive endophthalmitis in Zhongshan Ophthalmic Center between January 2010 and December 2018 were included retrospectively. Results A total of 127 patients (127 eyes) were included, and 108 (85%) had posttraumatic endophthalmitis. Streptococcus (21.4%), coagulase-negative Staphylococcus (14.5%), Aspergillus (6.9%), and Bacillus cereus (5.3%) were the common organisms. The proportion of Streptococcus decreased with age (40.0% in 0-3 years, 16.3% in 4-12 years, and 6.3% in 13-17 years), while coagulase-negative Staphylococcus increased from 5.7% to 18.8%. Overall, fluoroquinolones achieved the highest antibiotic susceptibility rate (> 95%), while the susceptibility of isolated bacteria to tobramycin and cefazolin was only 60.2% and 59.4%, respectively. The susceptibility rates of Gram-positive cocci to cephalosporins were nearly 90%. For Gram-negative bacilli, susceptibility to neomycin was 91.3%. Conclusion Trauma was the main etiology for pediatric endophthalmitis. Although Streptococcus was the most prevalent organism in general, the dominant pathogen varied with age, which merits clinical attention. Fluoroquinolones showed the highest antibiotic efficacy; however, commonly used antibiotics tobramycin and cefazolin showed relatively low antibiotic susceptibility. Thus, antibiotic resistance in pediatric populations merits clinical attention.

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Section: Discussioncontrasting

confidence: 45%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Etiology, microbiological isolates, and antibiotic susceptibilities in culture-proven pediatric endophthalmitis: a 9-year review

Yang

Lin

et al. 2020

Graefes Arch Clin Exp Ophthalmol

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“…The primary age group from 6 to 10 years of age accounts for the highest proportion, similar to the results of some recent studies [13], [14], [12]. Because the percentage of boys with penetrating eye is higher than that of girls, the rate of boys with endophthalmia after penetrating eye also was higher than that of girls [3], [14], [10], [11], [12], [15] . Our report shows that the number of injuries occurring in rural areas was a majority; this result was similar to other reports [3], [13].…”

Section: Discussionsupporting

confidence: 82%

Clinical and Microbiological Features of Pediatric Endopthalmitis After Open Globe Injury in the North of VietNam

Van¹,

Hon²,

Ánh³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: Pediatric endophthalmitis after open-globe injury had its clinical features, microbiological profile different from those in aldults. In Viet Nam, there was no report on the clinical and microbiological characteristic of pediatric posttraumatic endophthalmitis. Therefore, we conduct this study. AIM: To describe clinical features, ultrasound results, gram stain and culture results of endophthalmitis in pediatric open globe injuries. METHODS: Prospective non-controlled study. Case series of 30 eyes presenting with post-traumatic endophthalmitis between 2015 and 2016 were reviewed. RESULTS: Mean age was 8.03 ± 3.99 years. Metallic and organic etiologies were most common causes for injuries (n = 11). 27 cases had penetrating corneal trauma. Dense opaque vitreous was seen in 25 eyes. Retinal necrosis < 1 quadrant and chorioretinal abscess > 1 quadrant were most common fundus lesions. Dense vitreous opacity on ultrasound was most common (n = 28). Gram stain bacteria positivity was 93.3%, gram-positive were isolated in 63.3%. Vitreous samples were more often positive than aqueous (P = 0,002). CONCLUSION: Posttraumatic endophthalmitis in children is more common in boys aged 6-10 years and most often caused by injury with metallic and organic matter. Culture results were very low. Vitreous samples were more often positive than aqueous. Gram-positive bacteria were the most common causative organism.

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“…1 4 23 24 Higher incidence of endophthalmitis was observed in our study than those of previous adult-dominated studies because children may be less able to recognise or explain their symptoms when injured, and cooperate less well during ocular examination and treatment, leading to increased incidence of endophthalmitis in paediatric patients. 25 Therefore, identification of factors related to endophthalmitis in children with retained IOFB is of great significance for the prevention and timely diagnosis of endophthalmitis following injury.…”

Section: Discussionmentioning

confidence: 99%

Intraocular foreign body injury in children: clinical characteristics and factors associated with endophthalmitis

Yang

Zhao

et al. 2019

Br J Ophthalmol

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Background/AimsTo analyse the clinical characteristics of intraocular foreign body (IOFB) injury in children and evaluate factors associated with endophthalmitis development.MethodsPatients aged <18 years with IOFB attending Zhongshan Ophthalmic Center between January 2003 and July 2016 were included retrospectively. Demographic features, clinical characteristics and factors associated with endophthalmitis development were analysed.ResultsConsecutive subjects (n=484, 484 eyes) were included: mean age 10.12±4.54 years, 86.4% male. Fireworks (28.5%) were the most common cause of injury. Injury of uncertain cause (17.5%), fireworks (36.7%) and metal splatter (31.7%) accounted for most injuries in the 0–3, 4–12 and 13–17 years age groups, respectively. Plant branches (16.7%) and fireworks (31.1%) were the most common causes of injuries in females and males, respectively. Endophthalmitis occurred in 116 patients (24.0%), with metallic IOFB (OR=0.338, p=0.001), intraocular haemorrhage (OR=0.100, p<0.001) and uveal tissue prolapse (OR=0.206, p<0.001) conferring lower risk, while zone II wound (OR=4.336, p<0.001) and traumatic lens rupture (OR=2.567, p=0.028) were associated with higher risk.ConclusionClinical characteristics of children with IOFB injury differ from those of adults. Fireworks are the most common cause of injury, indicating a ban on children igniting fireworks should be advocated. Safety education and protective measures should vary by age and sex. Endophthalmitis is associated with zone II wound, traumatic lens rupture, IOFB material, intraocular haemorrhage and uveal tissue prolapse, which has clinical relevance.

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Pediatric Infectious Endophthalmitis

Cited by 20 publications

References 30 publications

Etiology, microbiological isolates, and antibiotic susceptibilities in culture-proven pediatric endophthalmitis: a 9-year review

Etiology, microbiological isolates, and antibiotic susceptibilities in culture-proven pediatric endophthalmitis: a 9-year review

Clinical and Microbiological Features of Pediatric Endopthalmitis After Open Globe Injury in the North of VietNam

Intraocular foreign body injury in children: clinical characteristics and factors associated with endophthalmitis

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