Pediatric-Inspired Regimens in the Treatment of Acute Lymphoblastic Leukemia in Adolescents and Young Adults: A Systematic Review

Abstract

Adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL) have significantly worse outcomes than their younger counterparts. Current treatment guidelines rely mostly on non-randomized retrospective studies. We performed a systematic review of studies published within the last 15 years comparing pediatric-inspired regimens (PIR) versus adult-type regimens or performing an age-stratified analysis of outcomes in the AYA population. Due to the heterogeneity of data, a meta-analysis was not possible. However, the gathered data show a trend toward improvement in outcomes and an acceptable toxicity profile in patients treated with PIRs compared to conventional adult-type regimens. There is still room for further improvement, as older patients within the AYA population tend to perform poorly with PIR or conventional adult-type chemotherapy. Further randomized studies are needed to develop an optimal treatment strategy for AYA with ALL.

Application of montmorillonite powder in the treatment of acute small intestinal bleeding

“…During treatment, the patient should report to the doctor on other medications being used, including prescription drugs, over-the-counter drugs, and supplements. This helps doctors to fully understand the patient's medication situation, avoid unnecessary drug interactions, and ensure the maximum efficacy [22]. In conclusion, scientific and reasonable use methods and dosage are important guarantees for montmorillonite powder in the treatment of acute small intestinal bleeding.…”