Pediatric intracranial ependymal tumors: clinicopathologic evaluation of 28 cases

Ertan, Yeşim; Sezak, Murat; Kantar, Mehmet; Turhan, Tuncer; Arun, Serra; Çetingül, Nazan

doi:10.5146/tjpath.2009.00967

Cited by 1 publication

(2 citation statements)

References 28 publications

(42 reference statements)

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“…In ependymomas, there was statistically significant correlation between grades of ependymoma and Ki-67 level (P = 0.017) but not with p53 level (P = 0.158). Erten et al [33] and Ridley et al [34] found a significant relation between Ki-67 and histological grade. In a study of 30 pediatric ependymomas, Zamecnik et al [35] concluded that p53 and Ki-67 positivity was an indicator of aggressive tumor behavior and poor outcome.…”

Section: Discussionmentioning

confidence: 94%

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P53 and Ki-67 expression in primary pediatric brain tumors: Does it correlate with presentation, histological grade, and outcome?

et al. 2018

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Context:Pediatric brain tumors are a vexing problem for the neurosurgeon due to the fragile patient cohort. We attempt to find parameters which can help us to treat and prognosticate these patients in a better way.Aims:This study aims to correlate clinical presentation, outcome, and histological grade with P53 and Ki-67 expression in primary pediatric brain tumors.Setting Design:This was a prospective, observational study.Patients and Methods:Forty-seven patients with primary brain tumors in the age group 0–18 years were included in this study. Clinical presentation was noted. Patients were operated, and specimen was sent for histopathological and immunohistochemistry examination for p53 and Ki-67. The WHO classification of 2007 was used to grade the tumors. Follow-up was done at 3 and 6 months with Glasgow outcome score. Expression of p53 and Ki-67 in different tumors was correlated with clinical presentation, tumor grade and outcome.Analysis Method:Statistical Package for Social Science version 17. P < 0.05 was considered statistically significant.Results:There was statistically significant correlation between high tumor grade and high Ki-67 levels (P = 0.000). On post hoc analysis, there was a significant difference between p53 levels in Grade 1 and Grade 4 tumors. There was statistically significant correlation between neurological deficit and higher p53 levels (P = 0.040). There was statistically significant correlation between poor outcome and higher p53 (P = 0.034) and Ki-67 (P = 0.000) levels at 3 months follow-up which continued at 6 months.Conclusions:From this study, we conclude that p53 and Ki-67 expression in pediatric brain tumors is associated with poor outcome and correlates with tumor grade. Moreover, p53 expression correlates with neurological deficit.

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Section: Discussionmentioning

confidence: 94%

“…Erten et al . [ 33 ] and Ridley et al . [ 34 ] found a significant relation between Ki-67 and histological grade.…”

Section: Discussionmentioning

confidence: 99%

P53 and Ki-67 expression in primary pediatric brain tumors: Does it correlate with presentation, histological grade, and outcome?

et al. 2018

View full text Add to dashboard Cite

show abstract

Pediatric intracranial ependymal tumors: clinicopathologic evaluation of 28 cases

Cited by 1 publication

References 28 publications

P53 and Ki-67 expression in primary pediatric brain tumors: Does it correlate with presentation, histological grade, and outcome?

P53 and Ki-67 expression in primary pediatric brain tumors: Does it correlate with presentation, histological grade, and outcome?

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