Pediatric Liver Transplantation in Asia

Kasahara, Mureo

doi:10.1016/b978-0-323-63671-1.00041-0

Cited by 2 publications

(2 citation statements)

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“…Transplantasi hati adalah prosedur operasi pergantian hati sakit dengan hati sehat berasal dari orang lain dan saat ini telah menjadi terapi pilihan pada pasien anak dengan penyakit hati stadium akhir. [1][2][3] Komplikasi transplantasi hati pada resipien anak dan dewasa terdiri dari komplikasi bedah, rejeksi, infeksi, penyakit rekuren dan disfungsi organ (late-graft dysfunction). 4 Rejeksi salah satu komplikasi pasca transplantasi hati tersering pada anak, setelah infeksi merupakan respon imun tubuh terhadap benda/antigen asing pada organ donor yang dapat menyebaban kerusakan organ transplantasi.…”

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“…Temuan ini sama dengan laporan dari data National Center for Chilld Health and Development Jepang (NCCHD) 1964 hingga 2013, yang melaporkan bahwa penyakit kolestasis hati merupakan kelompok penyakit terbanyak dengan dominasi atresia billier sebagai indikasi tersering pada tranplantasi pasien usia <18 tahun. 3 Spada et al 13 juga menyatakan bahwa indikasi terbanyak transplantasi hati pada resipien anak adalah atresia billier, kolangitis sklerosing, sindrom Allagile dan PFIC. Berbeda dengan temuan pada kelompok resipien dewasa, Nacif et al 15 21 melaporkan bahwa fibrosis portal stage 2 keatas tidak dianjurkan digunakan pada prosedur transplantasi hati karena memiliki risiko terhadap morbiditas dan mortalitas resipien.…”

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The Differences of Histomorphologic Profiles of Liver Tissue of Resipient and Donor Postpaediatric Liver Transplantation between Rejection and Non Rejection Patients in Anatomical Pathology Department of FKUI/RSCM 2010-2019

Perkasa¹,

Stephanie²,

Rahadiani³

et al. 2022

MPI

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BackgroundLiver rejection is an immune system response of recipient in which attacking the antigen originating from a donor that can causedamage to the transplanted organ. Although the prevalence of liver rejection has decreased due to the use of immunosuppressivedrugs, it is estimated that 20-40% of recipients still experience rejection and are at risk of re-transplantation and even death. Thisstudy aims to investigating histomorphological characteristics that can play a role as risk factors for rejection by assessing thedifferences in histomorphological characteristics before transplantation between recipient groups with rejection and non-rejection inpediatric liver transplant recipients in the Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Dr.Cipto Mangunkusumo (PA-FKUI/RSCM)MethodsThis study was an analytical study with a cross sectional design, using secondary data from the archives of the Department ofAnatomical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo 2010-2019. The clinical andhistopathologic data obtained were analyzed using comparative statistical tests.ResultsRejection were found in 25% of recipients. Rejection were more common in the group of recipients aged >1 (75%), male (58%),cirrhosis 4C (92%) and mild portal inflammation (56%). Rejection were more common in the group of donor with male (66%) andsteatosis ≤10% (92%). There were no significant differences in the histomorphological profiles of recipients and donors with orwithout rejection.ConclusionThe histomorphologic profiles of both recipients and donors were known to be descriptively associated with complications of posttransplant liver rejection. However, in terms of analysis, there was not any significant differences

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