Pediatric living donor intestine transplant following an atypical complication of COVID-19: A unique case report from India

Chaubal, Gaurav; Hatimi, Hunaid; Nanavati, Aditya; Deshpande, Apoorv; Andankar, Parmanand; Biradar, Vishnu; Gupte, Parijat; Hanchnale, Pavan; Bhalerao, Suryabhan; Tambe, Shrinivas

doi:10.1111/ajt.16798

Cited by 9 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In an additional note, there is a report of a 9-year-old female with short bowel syndrome 3 months of post-COVID-19, which required a small bowel transplant [63]. This indicates that COVID may be part of the transplant world in ways we have not yet anticipated.…”

Section: Limitationsmentioning

confidence: 99%

Solid Organ Transplantation in SARS-CoV-2 Recovered Transplant Candidates: a Comprehensive Review of Recent Literature

et al. 2022

View full text Add to dashboard Cite

Purpose of Review As the coronavirus disease 2019 (COVID-19) pandemic continues to surge, determining the safety and timing of proceeding with solid organ transplantation (SOT) in transplant candidates who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and who are otherwise transplant eligible is an important concern. We reviewed the current status of protocols and the outcomes of SOT in SARS-CoV-2 recovered patients. Recent Findings We identified 44 published reports up through 7 September 2021, comprising 183 SOT [kidney = 115; lung = 27; liver = 36; heart = 3; simultaneous pancreas-kidney (SPK) = 1, small bowel = 1] transplants in SARS-CoV-2 recovered patients. The majority of these were living donor transplants. A positive SARS-CoV-2 antibody test, although not obligatory in most reports, was a useful tool to strengthen the decision to proceed with transplant. Two consecutive real-time polymerase chain test (RT-PCR) negative tests was one of the main prerequisites for transplant in many reports. However, some reports suggest that life-saving transplantation can proceed in select circumstances without waiting for a negative RT-PCR. In general, the standard immunosuppression regimen was not changed. Summary In select cases, SOT in COVID-19 recovered patients appears successful in short-term follow-up. Emergency SOT can be performed with active SARS-CoV-2 infection in some cases. In general, continuing standard immunosuppression regimen may be reasonable, except in cases of inadvertent transplantation with active SARS-CoV-2. Available reports are predominantly in kidney transplant recipients, and more data for other organ transplants are needed.

show abstract

Section: Limitationsmentioning

confidence: 99%

Solid Organ Transplantation in SARS-CoV-2 Recovered Transplant Candidates: a Comprehensive Review of Recent Literature

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Notably, SBT are performed in low numbers independent from the pandemic and data may thus need to be interpreted with caution. An interesting case report of a SBT post-COVID-19 in a child that developed small bowel gangrene subsequent to an SMA thrombosis has been reported recently [20] . Although a rare complication of COVID, it is expected that transplants in patients developing end-stage-organ failure subsequent to COVID will become more frequent.…”

Section: Discussionmentioning

confidence: 99%

Global Impact of the COVID-19 Pandemic on Solid Organ Transplant

Kute

Tullius

Rane

et al. 2022

Transplantation Proceedings

View full text Add to dashboard Cite

Introduction COVID-19 has drastically impacted the transplant services, but there is limited understanding the discrepancy in COVID-19 impact over various regions of the world. Methods We have explored the global observatory for organ donation and transplantation (GODT) data for assessing the transplant number changes between the calendar year 2019(n = 157301) and 2020(129681). Results There was disproportionate impact of COVID-19 for different areas of the world. Globally, there was a decline of 17.5%, in which deceased donation, kidney (20.9%), pancreas (16.2%), lung (12.7%), liver (11.3%) and heart (8%) transplantation declined disproportionally in different regions of the world. While pandemic affected almost all geographic regions and nations, but China and USA were mostly able to recover from the initial halt of the transplant practices by the pandemic, so that there was a cumulative increase in transplant numbers. Conclusion Our data, shows that developing nations lagged behind and developed nations have been able to recover their transplantation programs in the pandemic. Further policy making and preparedness is required to safeguard the most vulnerable areas of the world to minimize the impact of any future pandemic in transplantation practices.

show abstract

“…During the coronavirus disease 2019 (COVID-19) pandemic, transplantation rates initially declined in India 5 and gradually recovered with the implementation of National Organ and Tissue Transplant Organization transplant guidelines 6,7 and the ability to cope with the pandemic. Table 2 summarizes milestones in SOT in India [8][9][10][11][12][13][14][15][16][17][18][19] Heart-Lung Transplants At the time of this report, there were <10 government institutions performing heart transplant (Figure 2B…”

Section: History and Transplant Volumes Of Live And Deceased Donor Tr...mentioning

confidence: 99%

Section: History and Transplant Volumes Of Live And Deceased Donor Tr...mentioning

confidence: 99%

Current Status, Challenges, and Opportunities of Organ Donation and Transplantation in India

et al. 2023

View full text Add to dashboard Cite

DISCREPANCY BETWEEN LIVE AND DECEASED DONOR TRANSPLANTS IN INDIAWe intend to elaborate on the current status, diversity in access, equity, and economics of solid organ transplantation (SOT) in India. Currently, India performs the third largest volume of organ transplants after the United States and China. [1][2][3] Notably, <10% of patients with organ failure have access to SOT worldwide. The Indian Ministry of Health estimates a gap of approximately 175 000 kidneys, 50 000 livers, hearts, and lungs in addition to 2500 pancreas. TheNewsletter Transplant (2018 data) reported on 12 758 patients wait-listed for kidneys, 4173 for liver, 425 for heart, 75 for lung, 48 for pancreas, and 6 for small bowel transplants (SBTs) for in India. 4 Deceased donation rates have remained stable and <1 per million population from 2013 to 2021. To achieve self-sufficiency in organ donation, the estimated deceased donation rate in India will need to achieve a rate of 62 per million population. The distinguishing feature of Indian transplant programs is their predominant reliance on living donation (87%), with only 13% of the kidney transplant volume deriving from deceased donors (DD). [1][2][3] There are also stark geographic differences in India with active DD programs in South and West India, whereas DD has not been initiated in Northeast India. Moreover, donation after the circulatory determination of death and kidney-paired exchange programs are still underdeveloped in India (<1%) and should be promoted.

show abstract

Pediatric living donor intestine transplant following an atypical complication of COVID-19: A unique case report from India

Cited by 9 publications

References 18 publications

Solid Organ Transplantation in SARS-CoV-2 Recovered Transplant Candidates: a Comprehensive Review of Recent Literature

Solid Organ Transplantation in SARS-CoV-2 Recovered Transplant Candidates: a Comprehensive Review of Recent Literature

Global Impact of the COVID-19 Pandemic on Solid Organ Transplant

Current Status, Challenges, and Opportunities of Organ Donation and Transplantation in India

Contact Info

Product

Resources

About