Pediatric Microbial Keratitis: A Tertiary Care Center Report

Abstract

Background: Microbial keratitis in children can cause visual loss and amblyopia. In this study, epidemiological features of microbial keratitis in children was examined at a tertiary care center in Iran. Methods: Sixty-three cases of microbial keratitis under the age of 15 admitted at Khalili hospital, Shiraz, Iran, during five years, were reviewed. Patients' age, gender, residential area, ulcer size, causative organism, surgical, and medical treatment were investigated. Results: Mean age of patients was 5.2 ± 4.8 years and 68.2% were under five years old. The prevalence of microbial keratitis was significantly higher in males than females (P = 0.003), especially in children coming from rural areas. Ulcers larger than 5 mm were observed more than smaller ones (P ≤ 0.0001) in hospitalized children. Ocular trauma was the most common risk factor (present in 56.9%), while in 22.4%, no risk factor was detected. The most causative microbial agent was Staphylococcus (42.8%). Fungus was detected in two cases and herpes simplex was suspected in eight cases. In 54% recovery was observed with medical therapy; mainly by combination of cefazolin-gentamicin and ceftazidime-vancomycin drops. Penetrating keratoplasty was needed in 16.9% and conjunctival flap in 14.7% of recalcitrant cases. Overall recovery from microbial keratitis was observed in 72% of cases, who showed complete healing of ulcer or significant decrease in size at the time of discharge from the hospital. Conclusions: Pediatric microbial keratitis was more common under the age of five years old and trauma was the main predisposing factor. Staphylococcus was the main causative microorganism and recovery was observed with topical treatment in the majority of cases. Trauma prevention and timely treatment is recommended.

A study on childhood microbial keratitis in South India

“…Similar to other studies, in our study also, males were commonly affected than females,[ 13 ] with a male: female ratio of 1.5:1. In our study, 72.6% of children were from urban areas.…”

“…In our study, trauma was the leading predisposing factor for microbial keratitis, consistent with other studies from India, Iran, and Saudi Arabia. [ 13 , 15 , 16 ] Trauma was mostly caused by fingernail, stick, stone, pencil, and toys. This highlights the necessity for framing strict safety rules, especially in outdoor and indoor playgrounds for children.…”

Common bacterial causes of external ocular infections, associated risk factors and antibiotic resistance among patients at ophthalmology unit of Felege Hiwot Referral Hospital, Northwest Ethiopia: a cross-sectional study

“…In most conjunctivitis infection, allergy is one of the major predisposing factors. Itching symptom of allergy might be a cause for skin contaminants to be introduced to the eye and cause chronic bacterial ocular infection [ 41 ].…”

Thyroid-Disrupting Effects of Exposure to Fipronil and Its Metabolites from Drinking Water Based on Human Thyroid Follicular Epithelial Nthy-ori 3-1 Cell Lines

“…T4 plays a critical role in skeletal development and linear growth during prepuberty − suggesting that we should pay attention to the impact of FPM exposure on adolescent growth and development in future population investigations. When T4 synthesis has been at a high level for a long time and released into circulation, it forms T3 through the process of deiodination; high levels of T3/T4 decrease TSH secretion . Excessive thyroid hormone synthesis or release results in clinical hyperthyroidism; therefore, since FPM stimulated thyroid follicular cells to secrete more thyroxine, daily oral exposure to FPM may trigger a thyroid hormone disorder.…”