Pediatric neurological complications associated with the A(H1N1)pdm09 influenza infection

Frobert, Émilie; Sarret, Catherine; Billaud, Geneviève; Gillet, Yves; Escuret, Vanessa; Floret, D.; Casalegno, Jean-Sébastien; Bouscambert, Maude; Morfin, Florence; Javouhey, Étienne; Lina, Bruno

doi:10.1016/j.jcv.2011.08.018

Cited by 22 publications

(26 citation statements)

References 32 publications

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“…It is also unclear if specific viral illnesses have a particular ability to provoke febrile seizures. Influenza A has been strongly implicated (Chung and Wong, 2007;Hara et al, 2007;Frobert et al, 2011;Ozkan et al, 2011). Human corona virus HKU1 has been associated with a higher rate of febrile seizures than respiratory syncytial virus, parainfluenza virus type 1, or adenovirus (Lau et al, 2006).…”

Section: Risk Factors For a First Febrile Seizurementioning

confidence: 99%

Febrile seizures and genetic epilepsy with febrile seizuresplus(GEFS+)

Camfield

2015

Epileptic Disorders

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Aim. To review the literature about febrile seizures and GEFS plus with special emphasis on management and outcome. Methods. Selected literature review. Results. Febrile seizures are the most common convulsive event in humans, occurring in 2-6% of the population. The aetiology is complex with strong evidence for a heterogeneous genetic predisposition interacting with fever of any cause, with certain viral infections having a greater effect. A large amount of literature has established that febrile seizures have no long-term consequences on cognition or behaviour. Unfortunately, about 40% of children with a first febrile seizure will have a recurrence. The strongest predictor of recurrence is age <14-16 months at the time of the first febrile seizure. Epilepsy follows febrile seizures in ∼3% cases, with the concepts of simple and complex febrile seizures providing relatively weak prediction. Very prolonged febrile seizures may lead to mesial temporal sclerosis and temporal lobe epilepsy although the degree of risk remains uncertain. Investigations beyond establishing the cause of the provoking fever are nearly always unnecessary.

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Section: Risk Factors For a First Febrile Seizurementioning

confidence: 99%

Febrile seizures and genetic epilepsy with febrile seizuresplus(GEFS+)

Camfield

2015

Epileptic Disorders

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“…In a French study of 181 children admitted to hospital with H1N1pdm09, 14 (7.7 %) had CNS dysfunction; of the 14 children (median age, 5.1 years), eight had febrile seizures and three had encephalitis or encephalopathy [39]. Twenty-four of the 181 children needed admission to ICU, however, including nine of those with CNS complications (38 % of the ICU cohort).…”

Section: Clinical Manifestations Of Diseasementioning

confidence: 99%

The burden of seasonal and pandemic influenza in infants and children

2013

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The burden of influenza is unevenly distributed, with more severe outcomes in children aged <5 years than older children and adults. In spite of this, immunisation policies for young children are far from universal. This article provides an overview of the published evidence on the burden of influenza in children worldwide, with a particular interest in the impact of pandemic influenza in 2009–2010 (caused by the H1N1pdm09 virus). In an average season, up to 9.8 % of 0- to 14-year olds present with influenza, but incidence rates can be markedly higher in younger children. Children aged <5 years have greater rates of hospitalisation and complications than their older counterparts, particularly if the children have co-existing illnesses; historically, this age group have had higher mortality rates from the disease than other children, although during the 2009–2010 pandemic the median age of those who died of influenza was higher than in previous seasons. Admissions to hospital and emergency departments appear to have been more frequent in children with H1N1pdm09 infections than during previous seasonal epidemics, with pneumonia continuing to be a common complication in this setting. Outcomes in children hospitalised with severe disease also seem to have been worse for those infected with H1N1pdm09 viruses compared with seasonal viruses. Studies in children confirm that vaccination reduces the incidence of seasonal influenza and the associated burden, underlining the importance of targeting this group in national immunisation policies. Conclusions: Children aged <5 years are especially vulnerable to influenza, particularly that caused by seasonal viruses, and vaccination in this group can be an effective strategy for reducing disease burden.

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“…Neurologic complications are relatively uncommon in association with influenza and are reported to be observed in 1 to 4 per 100 000 patient-years. 1 Seizures and encephalopathy are the most frequently reported neurologic problems; however, stroke, acute disseminated encephalomyelitis, Guillain-Barré syndrome, transverse myelitis, Reye syndrome, etc have also been seen. 1 We report on a child who presented with a relatively rare complication of influenza: mild encephalopathy with reversible splenial lesion.…”

mentioning

confidence: 99%

“…1 Seizures and encephalopathy are the most frequently reported neurologic problems; however, stroke, acute disseminated encephalomyelitis, Guillain-Barré syndrome, transverse myelitis, Reye syndrome, etc have also been seen. 1 We report on a child who presented with a relatively rare complication of influenza: mild encephalopathy with reversible splenial lesion. [2][3][4] We also present a case series of children with neurologic complications in association with a diagnosis of influenza over a period of 1 year.…”

mentioning

confidence: 99%