Pediatric Nonalcoholic Fatty Liver Disease: A Comprehensive Review

Lindback, Sarah; Gabbert, Charles; Johnson, B. Lamar; Smorodinsky, Emmanuil; Sirlin, Claude B.; Garcia, Natalie; Pardee, Perrie E.; Kistler, Kristin; Schwimmer, Jeffrey B.

doi:10.1016/j.yapd.2010.08.006

Cited by 38 publications

(32 citation statements)

References 220 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Between February 2008 and October 2010, we prospectively included a cohort of 121 consecutive severely obese children who were admitted to a tertiary center-based lifestyle intervention clinical practice, especially in the pediatric population ( 5 ). Serum alanine aminotransferase, however, correlates somewhat with infl ammation, but not with liver steatosis.…”

Section: Study Design and Patientsmentioning

confidence: 99%

“…The reported data from all these studies, obtained in different populations with different disease prevalences, fi t adequately within our posttest probability models. This fi nding emphasizes that for the individual patient, factors that infl uence the prevalence of hepatic steatosis (eg, age, race, presence of components of the metabolic syndrome) have to be taken into consideration as these strongly infl uence the predictive value of US examination results ( 5,27 ).…”

Section: Ultrasonography: Hepatic Steatosis In Obese Adolescentsmentioning

confidence: 99%

See 1 more Smart Citation

US Cannot Be Used to Predict the Presence or Severity of Hepatic Steatosis in Severely Obese Adolescents

Bohte

Koot²,

Baan-Slootweg³

et al. 2012

Radiology

View full text Add to dashboard Cite

Purpose:To evaluate the diagnostic accuracy of ultrasonography (US) for the assessment of hepatic steatosis in severely obese adolescents, with proton magnetic resonance (MR) spectroscopy as the reference standard, and to provide insight on the infl uence of prevalence on predictive values by calculating positive and negative posttest probabilities. Materials and Methods:This prospective study was institutional review board approved. All participants, and/or their legal representatives, gave written informed consent. Sensitivity, specifi city, positive predictive value (PPV), and negative predictive value (NPV) were calculated for the overall presence of steatosis and for the presence of substantial (moderate to severe) steatosis. Positive and negative posttest probabilities were calculated and plotted against prevalence. Results:A total of 104 children (47 male, 57 female) were prospectively included. Conclusion:Positive US results in severely obese adolescents cannot be used to accurately predict the presence and severity of hepatic steatosis, and additional imaging is required. Negative US results exclude the presence of substantial steatosis with acceptable accuracy. Steatosis prevalence differs among specifi c populations, strongly infl uencing posttest probabilities.q RSNA, 2011 1

show abstract

Section: Study Design and Patientsmentioning

confidence: 99%

Section: Ultrasonography: Hepatic Steatosis In Obese Adolescentsmentioning

confidence: 99%

US Cannot Be Used to Predict the Presence or Severity of Hepatic Steatosis in Severely Obese Adolescents

Bohte

Koot²,

Baan-Slootweg³

et al. 2012

Radiology

View full text Add to dashboard Cite

show abstract

“…25–27 Based on their recommendations, children aged 10 years or older with a BMI higher than the 85th percentile should be screened if there are risk factors. Once the BMI percentile exceeds 95%, screening should begin even in the absence of risk factors.…”

Section: Screening For Nonalcoholic Fatty Liver Diseasementioning

confidence: 99%

Screening for Metabolic and Reproductive Complications in Obese Children and Adolescents

Irizarry¹,

Brito²,

Freemark³

2014

Pediatr Ann

View full text Add to dashboard Cite

Childhood obesity is associated with a number of metabolic comorbidities. These include glucose intolerance and type 2 diabetes mellitus, hyperlipidemia, fatty liver disease, and reproductive complications, such as polycystic ovary syndrome. The occurrence of these complications in a child or adolescent may result in progressive health decline at an early age. We, therefore, advocate screening and early diagnosis. This purpose of this review is to outline a rational, evidence-based approach to screening obese children and adolescents for metabolic and reproductive complications. In each section, the aim is to provide the primary care provider with a review of the literature supporting current screening practices. As such, this review is designed to assist the primary care provider in the selection and interpretation of screening tests and to make recommendations regarding the referral of patients for subspecialty care.

show abstract

“…지방간염은 부검연구에서 23%였으며 17) , 간생검으로 확진한 지방간질환에서 지방간염의 유병률은 84∼ 86%로 높게 보고되기도 하였다 3,4) . 미국 NASH Clinical Research Network (NASH CRN)연구에서는 지역 에 따라 다르지만, 경계성 지방간염 38%, 분명한 지방 간염 39%로 보고하였다 18) .…”

Section: 소아 지방간은 2세에도 증례보고가 있으나 11∼13unclassified

“…음료수의 과당은 성인지방 간의 독립적인 위험인자이다 1∼6, 13,36,39) . 동물실험에서도 고지방, 고과당, 고탄수화물식을 준 쥐에서 고지방식만 , 소아 지방간에 서 삶의 질이 낮게 보고되고 있다 3,18) . .…”

Section: 자연경과unclassified

Nonalcoholic Fatty Liver Disease in Children

Seo

2011

Korean J Pediatr Gastroenterol Nutr

View full text Add to dashboard Cite

Pediatric Nonalcoholic Fatty Liver Disease: A Comprehensive Review

Cited by 38 publications

References 220 publications

US Cannot Be Used to Predict the Presence or Severity of Hepatic Steatosis in Severely Obese Adolescents

US Cannot Be Used to Predict the Presence or Severity of Hepatic Steatosis in Severely Obese Adolescents

Screening for Metabolic and Reproductive Complications in Obese Children and Adolescents

Nonalcoholic Fatty Liver Disease in Children

Contact Info

Product

Resources

About