Pediatric Oncology in the Arab World

Sultan, Iyad

doi:10.1007/978-3-319-74365-3_17-1

Cited by 3 publications

(3 citation statements)

References 74 publications

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“…The findings of this study shed light on the challenges faced by SECI, which are likely applicable to many similar centers in LMICs. One major issue is the deficiency of well-established pediatric oncology centers that cover all regions of Egypt, as better healthcare facilities are predominantly available in the capital and major cities [ 20 ]. As a result, SECI receives a higher number of patients compared to UKK.…”

Section: Discussionmentioning

confidence: 99%

“…Alarmingly, 83% of these new childhood cancer cases and 99% of treatment abandonment were reported in LMICs [ 25 ]. Limited data are available from Arab countries, especially regarding therapy abandonment [ 20 ]. The findings regarding non-compliance with therapy in SECI in this study were consistent with results from other LMICs studies [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

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Comparing presentations and outcomes of children with cancer: a study between a lower-middle-income country and a high-income country

Farrag,

Ghazaly,

Mohammed

et al. 2023

BMC Pediatr

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Background Substantial progress has been achieved in managing childhood cancers in many high-income countries (HICs). In contrast, survival rates in lower-middle-income countries (LMICs) are less favorable. Here, we aimed to compare outcomes and associated factors between two large institutions; Egypt (LMIC) and Germany (HIC). Methods A retrospective review was conducted on newly diagnosed children with cancer between 2006 and 2010 in the departments of pediatric oncology at the South Egypt Cancer Institute (SECI) (n = 502) and the University Hospital of Cologne-Uniklinik Köln (UKK) (n = 238). Characteristics including age, sex, diagnosis, travel time from home to the cancer center, the time interval from initial symptoms to the start of treatment, treatment-related complications, compliance, and outcome were analyzed. A Cox proportional hazards regression model was applied to investigate the influence of risk factors. Results The most common diagnoses in SECI were leukemia (48.8%), lymphomas (24.1%), brain tumors (1%), and other solid tumors (24.7%), compared to 22.3%, 19.3%, 28.6%, and 26.5% in UKK, respectively. Patients from SECI were younger (5.2 vs. 9.0 years, P < 0.001), needed longer travel time to reach the treatment center (1.44 ± 0.07 vs. 0.53 ± 0.03 h, P < 0.001), received therapy earlier (7.53 ± 0.59 vs. 12.09 ± 1.01 days, P = 0.034), showed less compliance (85.1% vs. 97.1%, P < 0.001), and relapsed earlier (7 vs. 12 months, P = 0.008). Deaths in SECI were more frequent (47.4% vs. 18.1%) and caused mainly by infection (60% in SECI, 7% in UKK), while in UKK, they were primarily disease-related (79% in UKK, 27.7% in SECI). Differences in overall and event-free survival were observed for leukemias but not for non-Hodgkin lymphoma. Conclusions Outcome differences were associated with different causes of death and other less prominent factors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparing presentations and outcomes of children with cancer: a study between a lower-middle-income country and a high-income country

Farrag,

Ghazaly,

Mohammed

et al. 2023

BMC Pediatr

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“…Overall, the Middle East faces considerable barriers to pediatric cancer clinical trial development and execution, including lack of standardized approaches to diagnosis, wide variations in health care infrastructure, financial barriers, and geopolitical instability, which lead to delays in diagnosis, treatment abandonment, and ultimately poorer outcomes. 84,94 However, twinning initiatives with large specialized centers throughout the region have resulted in promising improvements in pediatric cancer care, 94 which highlights the utility of twinning relationships in promoting the foundational pillars of the Cure All framework.…”

Section: Methodsmentioning

confidence: 99%

Mapping Pediatric Oncology Clinical Trial Collaborative Groups on the Global Stage

Major

Palese

Ermis

et al. 2022

JCO Global Oncology

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PURPOSE The global pediatric oncology clinical research landscape, particularly in Central and South America, Africa, and Asia, which bear the highest burden of global childhood cancer cases, is less characterized in the literature. Review of how existing pediatric cancer clinical trial groups internationally have been formed and how their research goals have been pursued is critical for building global collaborative research and data-sharing efforts, in line with the WHO Global Initiative for Childhood Cancer. METHODS A narrative literature review of collaborative groups performing pediatric cancer clinical research in each continent was conducted. An inventory of research groups was assembled and reviewed by current pediatric cancer regional and continental leaders. Each group was narratively described with identification of common structural and research themes among consortia. RESULTS There is wide variability in the structure, history, and goals of pediatric cancer clinical trial collaborative groups internationally. Several continental regions have longstanding endogenously-formed clinical trial groups that have developed and published numerous adapted treatment regimens to improve outcomes, whereas other regions have consortia focused on developing foundational database registry infrastructure supported by large multinational organizations or twinning relationships. CONCLUSION There cannot be a one-size-fits-all approach to increasing collaboration between international pediatric cancer clinical trial groups, as this requires a nuanced understanding of local stakeholders and resources necessary to form partnerships. Needs assessments, performed either by local consortia or in conjunction with international partners, have generated productive clinical trial infrastructure. To achieve the goals of the Global Initiative for Childhood Cancer, global partnerships must be sufficiently granular to account for the distinct needs of each collaborating group and should incorporate grassroots approaches, robust twinning relationships, and implementation science.

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Noncompliance of pediatric cancer patients with chemotherapy: A single-center experience in a lower-middle income country

Farrag,

Mohammed,

Ghazaly

et al. 2023

Pediatric Hematology and Oncology

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Pediatric Oncology in the Arab World

Cited by 3 publications

References 74 publications

Comparing presentations and outcomes of children with cancer: a study between a lower-middle-income country and a high-income country

Comparing presentations and outcomes of children with cancer: a study between a lower-middle-income country and a high-income country

Mapping Pediatric Oncology Clinical Trial Collaborative Groups on the Global Stage

Noncompliance of pediatric cancer patients with chemotherapy: A single-center experience in a lower-middle income country

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