Pediatric optic neuritis and multiple sclerosis: Who is at risk for progression?

Subramanian, Prem S.

doi:10.1016/j.jaapos.2011.06.002

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…The severity of pediatric ON is variable, ranging from 20/15 to no light perception,109 although in general, pediatric ON is considered to have more severe vision loss at presentation than in the adult counterpart,108 and in one study 84% had 20/200 or worse at presentation 110…”

Section: Special Scenarios In the Treatment Of Onmentioning

confidence: 99%

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Current options for the treatment of optic neuritis

Pula¹,

MacDonald²

2012

OPTH

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Optic neuritis can be defined as typical (associated with multiple sclerosis, improving independent of steroid treatment), or atypical (not associated with multiple sclerosis, steroid-dependent improvement). Causes of atypical optic neuritis include connective tissue diseases (eg, lupus), vasculitis, sarcoidosis, or neuromyelitis optica. In this manuscript, updated treatment options for both typical and atypical optic neuritis are reviewed. Conventional treatments, such as corticosteroids, therapeutic plasma exchange, and intravenous immunoglobulin therapy are all discussed with commentary regarding evidence-based outcomes. Less commonly used treatments and novel purported therapies for optic neuritis are also reviewed. Special scenarios in the treatment of optic neuritis – pediatric optic neuritis, acute demyelinating encephalomyelitis, and optic neuritis occurring during pregnancy – are specifically examined.

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Section: Special Scenarios In the Treatment Of Onmentioning

confidence: 99%

“…This bilaterality historically was considered a negative predictor of conversion to MS,109 but in a meta-analysis, while abnormal MRI made conversion to MS 25-fold higher in risk, it did not appear that bilaterality made it less likely 110…”

Section: Special Scenarios In the Treatment Of Onmentioning

confidence: 99%