Pediatric Pleomorphic Adenoma of the Parotid: Case Report, Review of Literature and Novel Therapeutic Targets

Meshram, Girish Gulab; Kaur, Neeraj; Hura, Kanwaljeet Singh

doi:10.3390/children5090127

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…The most frequent salivary gland tumor, pleomorphic adenoma, is sometimes referred to as a benign mixed tumor due to its dual genesis from myoepithelial and epithelial components [ 1 ]. It makes up two-thirds of all salivary gland tumors, making it the most prevalent [ 2 , 3 ]. Pleomorphic adenomas, the most common type of tumor, make up about 66% of all salivary gland neoplasms [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Pleomorphic Adenoma of a Minor Salivary Gland of the Hard Palate: A Case Report

Panchal,

Wanjari

2023

Cureus

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Pleomorphic adenoma affects mostly the parotid gland (85%), submandibular glands (5%), and the minor salivary glands (5%). They are usually referred to as benign mixed tumors because they are composed of both epithelial cells, which are cells from the body's surface, and myoepithelial cells, present inside glands to aid in secretion. An 88-year-old male who had an ulcer for 10 days and a three to four-month-old swelling on his palate arrived in the OPD. On examination, at the intersection of the hard and soft palates, there is a single, well-delineated, nodular exophytic development of small salivary glands left to the median half (most of the pleomorphic adenomas are unilateral). For further and confirmatory diagnosis, fine needle aspiration cytology, immunohistochemistry tests, and radiodiagnosis, i.e., X-rays, were performed which revealed periapical abscess and swelling on palate unassociated with pus discharge. Surgical removal of the swelling and extraction of the root stump was done. The patient was asked to stop smoking strictly. Post-operatively, the patient was given suitable medications.

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Section: Introductionmentioning

confidence: 99%

Pleomorphic Adenoma of a Minor Salivary Gland of the Hard Palate: A Case Report

Panchal,

Wanjari

2023

Cureus

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“…Pleomorphic adenoma (PA) is the most common benign neoplasm of the salivary glands. It is also known as a benign mixed tumor (BMT), due to its dual origin from epithelial and myoepithelial elements (2,3,4). It represents 45-75% of all salivary gland tumors with an annual incidence of 2 to 3.5 cases per 100,000 inhabitants.…”

Section: Introductionmentioning

confidence: 99%

Rare case of pleomorphic adenoma presenting as peritonsilar tumor

Jovanović,

Valjarević,

Jovanović

2023

Medicinska istraživanja

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Pleomorphic adenoma, which is considered to be the most common benign neoplasm of small salivary glands, occurs mainly in the region of the hard palate with mild predilection for women and the peak incidence between the third and sixth decades of life. We present the case of a fifty-one-year-old patient with a left peritonsillar region tumor that the patient has been familiar with for several years. Clinical and radiological examination (computed tomography) indicated a clearly limited, encapsulated tumor change in the left peritonsillar region, 2.5 x 2.5 cm in diameter. The change was completely surgically removed transorally and pathohistologically verified as a pleomorphic adenoma of the small salivary gland. Computed tomography and correct pathohistological diagnosis are essential for the decision on surgical treatment in order to completely remove the lesion. Although it is a benign tumor, early detection is important for a timely decision for surgical treatment. Complete excision of tumor is necessary to prevent regrowth and possible malignant transformation.

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“…Of the major salivary glands parotid is most commonly involved. [1][2][3] Although these are tumors of salivary glands, they also involve other areas of head and neck like auditory canal, eyelids etc. Occasionally involvement of lacrimal gland is also seen.…”

Section: Introductionmentioning

confidence: 99%

Clinical profile and management of pleomorphic adenoma of head neck: our experience

Pawar

Nitnaware

Patel

et al. 2019

Int J Otorhinolaryngol Head Neck Surg

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Background: Pleomorphic adenoma constitutes one of the common salivary gland tumors. Our aim is to study the clinical presentation of pleomorphic adenoma, preoperative and postoperative histopathological findings and management of tumors.Methods: A retrospective study of 43 patients was conducted at department of ENT, Government Medical College and Hospital, Nagpur between January 2017 to February 2019. Data was collected and analysed. Results: Maximum patients were of age group 40-60 years with male preponderance. Parotid being most common gland involved, 35 cases of all 43 were post-operatively confirmed to be pleomorphic adenoma.Conclusions: Pleomorphic adenoma is most commonly diagnosed in age group 40-60 years. Surgical excision is treatment of choice. Long term follow-up of the cases is warranted owing to risk of late recurrences.

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Pediatric Pleomorphic Adenoma of the Parotid: Case Report, Review of Literature and Novel Therapeutic Targets

Cited by 6 publications

References 9 publications

Pleomorphic Adenoma of a Minor Salivary Gland of the Hard Palate: A Case Report

Pleomorphic Adenoma of a Minor Salivary Gland of the Hard Palate: A Case Report

Rare case of pleomorphic adenoma presenting as peritonsilar tumor

Clinical profile and management of pleomorphic adenoma of head neck: our experience

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