Background: Hospitalised children experience predictable and potentially preventable life-threatening events in hospital that may be reduced by early warning systems. With the current interest in developing a national PEW system, and in the absence of relevant literature, we present guidance from a mature programme that may be useful to those institutions that are currently planning implementation or modification of an existing system. Objectives: To develop an evidence and expert based observation and monitoring guidance as the standard and recommended practice underpinning a wider Paediatric Early Warning (PEW) system Design: Case study using mixed methods of literature reviews, consultation, focus groups and co-production. Setting: A specialist children’s hospital.Methods: This report outlines the development of the original guidance through consultation and co-production using a literature review and multi-professional focus groups and subsequent iterative changes. Results: The original (2008) and the current (2019) guidance are presented to show the modifications over time including ergonomic chart design, documenting parental concern, continuous monitoring, alarm management, fluid balance and hydration risk assessment, Sepsis 6, conditions to omit and de-escalate observations, and documentation of significant clinical events contemporaneously on the observation chart. Our guidance is compared to the Royal College of Nursing Guidance (2017), which includes good general guidance for performing routine observations correctly, but still limited guidance on the triage/ admission interface, frequency of routine observations, escalation and de-escalation of frequency and type of observations, and specialist observations.Conclusions: We have evolved evidence and expert based observation and monitoring guidance to support the implementation and maintenance of a PEW system over 12 years. The guidance sets standards of care to educate and guide clinicians and provides a template for assessment of that standard of care. TWEETABLE ABSTRACT Evidence and expert based observation and monitoring guidance to support the implementation and maintenance of a Paediatric Early Warning system.