Pediatric Rectal Adenocarcinoma With Mismatch Repair Deficiency Responds to Immunotherapy

A rare case of locally advanced DNA mismatch‐repair‐deficient adenocarcinoma of the colon in a 16‐year‐old male treated with neoadjuvant immunotherapy and single‐incision laparoscopic resection

“…11 However, to date, data for neoadjuvant immunotherapy are scarce, mainly due to the rarity of such tumours in children and adolescents. In adult patients, neoadjuvant immunotherapy of patients with localised MSI-h/dMMR CRC led to excellent treatment responses in two major phase 3 trials.…”