Pediatric reference intervals for bone markers

Yang, Lei; Grey, Vijaylaxmi

doi:10.1016/j.clinbiochem.2005.11.015

Cited by 111 publications

(81 citation statements)

References 56 publications

(43 reference statements)

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“…17 Grouping children into the 0.5-4 years, 5-12 years, and 13-17 years of age groups (male and female) was performed based on the subgroups used for similar studies in Uganda 15 and Tanzania 14 and also based on recommendations to establish sex-specific reference values during the pubertal stage. 21 Determination of the values by using combined sex for children 13 years of age was based on the general absence of sex differences for the parameters in these age groups. 14,15,22 There is a dearth of comprehensive age-and sex-specific biochemical reference values for children in Africa.…”

Section: Discussionmentioning

confidence: 99%

Biochemical and Hematologic Parameters for Children in the Middle Belt of Ghana

Dosoo

Asante

Kayan³

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. Reference values derived from developed countries are used in many countries in Africa for interpretation of laboratory results obtained during routine healthcare and clinical trials. Use of locally derived reference values has been recommended. The purpose of the study was to establish age-and sex-specific reference values for children in the middle belt of Ghana. Reference values were determined for 21 biochemical and 18 hematologic parameters by using Clinical and Laboratory Standards Institute C28-A3 guidelines in a sample of 1,442 healthy children. Hemoglobin, hematocrit, mean cell volume, erythrocytes, urea, and creatinine were lower when compared with values from northern countries but alanine aminotransferase, aspartate aminotransferase, and total bilirubin were higher. A panel of locally relevant age-and sex-specific reference values was established for commonly used biochemical and hematologic tests in children in the middle part of Ghana. This will help in interpretation of laboratory results for clinical management of patients, screening, and safety monitoring during clinical trials.

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Section: Discussionmentioning

confidence: 99%

Biochemical and Hematologic Parameters for Children in the Middle Belt of Ghana

Dosoo

Asante

Kayan³

et al. 2014

The American Society of Tropical Medicine and Hygiene

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“…OC is elevated in high bone turnover states and is reduced in low bone turnover states [15]. PD is present predominantly in articular cartilage and to a lesser extent in bone, whereas DPD is most abundant in mineralized tissues such as bone and dentine [14]. During the process of bone resorption, type I collagen, the most abundant organic component of bone, is fragmented into smaller peptides which are then released into the blood and eventually excreted into the urine.…”

Section: Introductionmentioning

confidence: 99%

“…Total ALP is considered to be an adequate marker for assessment of metabolic bone disease and it is often used due to convenience and low cost in evaluating and monitoring patients without liver disease. Total ALP is stable, with a relatively long half-life and no significant circadian variations [14]. Serum OC is derived from the most abundant non-collagenous protein in bone and is thought to be secreted exclusively by osteoblasts and thus correlates with osteoblastic activity, bone formation, and mineralization [15].…”

Section: Introductionmentioning

confidence: 99%

Biochemical markers of bone turnover in children with clinical bone fragility

Bowden

Akusoba

Hayes

et al. 2016

Journal of Pediatric Endocrinology and Metabolism

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Background: The role of biochemical bone turnover markers (BTMs) in assessing low bone mass and monitoring bisphosphonate treatment in pediatric patients with clinical bone fragility is not well established. The aim of the study was to examine the correlations of BTMs and the bone mineral density (BMD), and evaluate the effects of bisphosphonates therapy on BTMs in children with clinical bone fragility. Methods: Clinical data of 115 patients with clinical bone fragility (mean age 9.7±5.8 years), 102 of whom received bisphosphonates, were studied. Serum alkaline phosphatase (ALP), osteocalcin (OC), urine pyridinoline (PD) and deoxypyridinoline (DPD), BMD at baseline and subsequent years were analyzed. Results: There was a significant negative correlation between urine PD and lumbar BMD (slope = -0.29, p < 0.001). There were no correlations between BTMs and lumbar BMD Z-score. There was a significant positive correlation between serum OC and serum ALP, urine PD and DPD (p < 0.001). Serum OC, urine PD and DPD index, as expressed as measured value/upper limit of normal value for age, decreased during the first 3 years of bisphosphonate therapy. Conclusions: In children with clinical bone fragility, BTMs correlated with each other, but not with lumbar BMD Z-score. While they were not reliable predictors of degree of low BMD, the bone markers showed suppression during bisphosphonate therapy and may be helpful in monitoring the response to therapy.

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“…Many of the reference intervals in current use have been derived from the analysis of a small number of healthy or hospitalized individuals or are focused on a limited age interval with restricted partitions (11)(12)(13)(14)(15). Because of the challenges with recruiting study participants, only a small number of analytes have been studied (16 -18 ).…”

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confidence: 99%

Closing the Gaps in Pediatric Laboratory Reference Intervals: A CALIPER Database of 40 Biochemical Markers in a Healthy and Multiethnic Population of Children

et al. 2012

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BACKGROUND:Pediatric healthcare is critically dependent on the availability of accurate and precise laboratory biomarkers of pediatric disease, and on the availability of reference intervals to allow appropriate clinical interpretation. The development and growth of children profoundly influence normal circulating concentrations of biochemical markers and thus the respective reference intervals. There are currently substantial gaps in our knowledge of the influences of age, sex, and ethnicity on reference intervals. We report a comprehensive covariate-stratified reference interval database established from a healthy, nonhospitalized, and multiethnic pediatric population.

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Pediatric reference intervals for bone markers

Cited by 111 publications

References 56 publications

Biochemical and Hematologic Parameters for Children in the Middle Belt of Ghana

Biochemical and Hematologic Parameters for Children in the Middle Belt of Ghana

Biochemical markers of bone turnover in children with clinical bone fragility

Closing the Gaps in Pediatric Laboratory Reference Intervals: A CALIPER Database of 40 Biochemical Markers in a Healthy and Multiethnic Population of Children

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