Pediatric renal cell carcinoma

Sausville, Justin; Hernandez, David J.; Argani, Pedram; Gearhart, John P.

doi:10.1016/j.jpurol.2009.04.007

Cited by 50 publications

(42 citation statements)

References 48 publications

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“…RCC has been detected as a second malignancy during routine surveillance in survivors of leukemia, 66,125 supratentorial PNET, 66 WT, 67 and neuroblastoma. 55,126 In the Childhood Cancer Survivor Study, 51 kidney cancers were detected as second malignancies among 14 359 5-year survivors and another 28 as third or subsequent malignancies.…”

Section: Renal Tumor As a Second Malignancymentioning

confidence: 99%

An Approach to Renal Masses in Pediatrics

Malkan¹,

Loh²,

Bahrami³

et al. 2015

Pediatrics

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Renal masses in children may be discovered during routine clinical examination or incidentally during the course of diagnostic or therapeutic procedures for other causes. Renal cancers are rare in the pediatric population and include a spectrum of pathologies that may challenge the clinician in choosing the optimal treatment. Correct identification of the lesion may be difficult, and the appropriate surgical procedure is paramount for lesions suspected to be malignant. The purpose of this article is to provide a comprehensive overview regarding the spectrum of renal tumors in the pediatric population, both benign and malignant, and their surgical management.

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Section: Renal Tumor As a Second Malignancymentioning

confidence: 99%

An Approach to Renal Masses in Pediatrics

Malkan¹,

Loh²,

Bahrami³

et al. 2015

Pediatrics

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“…Generally, PRCC has a reported median age of anywhere from 9 to 17 years, differentiating these lesions from most other pediatric renal neoplasms, which occur earlier in life [ 78 ]. No racial or gender predominance has been consistently reported, although some indicated higher prevalence in African-Americans and in females.…”

Section: Defi Nition and Overviewmentioning

confidence: 99%

“…Unlike adult RCC, in which lesions are often found incidentally, patients with PRCC usually present with symptoms including protruding abdominal mass, abdominal pain, fever, hematuria, and weight loss, with only about 10 % presenting asymptomatically [ 8 , 78 ]. Additionally, children with PRCC are more likely to be found with locally advanced disease at diagnosis as compared with adults [ 78 ]. Also, a signifi cant number of PRCC patients present in the context of underlying syndromes such as von Hippel-Lindau disease and tuberous sclerosis or have been previously treated with chemotherapy for another pediatric neoplasm [ 70 ].…”

Section: Defi Nition and Overviewmentioning

confidence: 99%

Malignant Renal Tumors

Shehata

Naguib

Lin

et al. 2014

Pediatric Malignancies: Pathology and Imaging

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Renal tumors account for approximately 6-7 % of all pediatric cancers, with Wilms' tumor being the most common malignancy [ 1 , 2 ]. Current classifi cation and staging criteria for renal tumors, aided by advances in molecular and cytogenetic abnormalities, have allowed accurate diagnostic, staging, and therapeutic protocols [ 2 ], elucidated new categories of renal neoplasms, and created more inclusive classifi cation (Table 10.1 ) [ 2 , 3 ]. Overview of Imaging FeaturesThe imaging evaluation of a suspected pediatric renal mass should always begin with ultrasound. Sonography is readily available, can be performed without sedation and intravenous contrast, and does not expose the child to ionizing radiation. If a renal mass is identifi ed on ultrasound, further evaluation of the renal vessels and inferior vena cava (IVC) with both gray scale and color Doppler images are required to detect vascular extension, present in up to 10 % of cases [ 4 ]. Further evaluation with contrast enhanced computed tomography (CT) or magnetic resonance imaging (MRI) is also required for local staging of the mass prior to any intervention, as per the guidelines of the Children's Oncology Group (COG). Either modality can be used, depending on institutional availability and expertise [ 5 ].In keeping with the As Low As Reasonably Achievable (ALARA) principle regarding ionizing radiation exposure, pre-contrast and multiphase contrast enhanced CT images are not required for diagnosis or staging of pediatric renal tumors [ 6 ]. A single-phase study in the portal venous phase (approximately 50 s after contrast injection) suffi ciently stages a renal tumor and delineates relevant anatomy. Multiplanar CT reconstructions or multiplanar scanning with MRI can confi rm the renal origin of the mass and assess its relationship to vital structures such as the renal vessels. If a partial nephrectomy is being considered, multiphase images are helpful to determine the relationship of the mass to the renal vessels and collecting system. A CT of the chest is required in all malignant renal tumors to evaluate for potential lung metastasis. Wilm's Tumor Defi nitionWilms' tumor ( syn: nephroblastoma), a malignant neoplasm originating from nephrogenic blastemal cells, is the second most common malignant, solid extracranial tumor in children [ 1 , 7 , 8 ]. It is a traditional blastematous tumor, exhibiting various stages of embryonic development and multiple lines of differentiation. Clinical Features and EpidemiologyIn children ranging from 0 to 15 years of age, Wilms' tumor occurs in seven to ten cases per million annually (1 in 10,000 children) and accounts for approximately 95 % of renal tumors, and comprises 6-7 % of all pediatric tumors [ 7 , 9 , 10 ]. It is the fi fth most common pediatric tumor and the second most common intraabdominal tumor in children [ 11 ].

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“…1 Cyst-associated RCC or cystic RCC is extremely rare. 2 In clinical practice, it is difficult to preoperatively determine whether a complicated cyst is malignant. The translocations involving chromosome Xp11.2, the locus of the TFE3 gene in a large percentage of pediatric RCC, has been showed in recent years.…”

Section: Introductionmentioning

confidence: 99%

A rare cause of childhood renal cysts: Xp11.2 translocation renal cell carcinoma

Taşkınlar

Avlan

Çıtak

et al. 2015

CUAJ

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Original research E36Cite as: Can Urol Assoc J 2015;9(1-2):E36-8. http://dx.doi.org/10.5489/cuaj.2321 Published online January 12, 2015. AbstractPediatric renal cysts are rare, usually asymptomatic and incidentally detected in children. Cyst associated renal cell carcinoma (RCC) or cystic RCC is extremely rare in children. Bosniak classification system has been accepted for the management of cystic renal masses. Xp11.2 translocation RCC is a recently classified distinct subtype and usually affects children and adolescents. We report the case of a 10-year-old girl with Xp11.2 translocation RCC from a cyst of the right kidney.

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Pediatric renal cell carcinoma

Cited by 50 publications

References 48 publications

An Approach to Renal Masses in Pediatrics

An Approach to Renal Masses in Pediatrics

Malignant Renal Tumors

A rare cause of childhood renal cysts: Xp11.2 translocation renal cell carcinoma

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