Pediatric Rhabdoid Meningioma with Extension to the Heart: A First Case Report and Literature Review

Khairy, Sami; Al-Ahmari, Ahmed Nasser; Saeed, Mahfood Abdullah; Azzubi, Moutasem

doi:10.1016/j.wneu.2019.06.117

Cited by 3 publications

(6 citation statements)

References 22 publications

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“…From the prognostic point of view, previous studies suggest more aggressive behavior from RM that is associated with a high rate of local recurrence and even distant metastases [47][48][49][50][51], which is confirmed in our cohort. This is in line with previous observations which show that 40% of patients develop tumor recurrences [5,8,[19][20][21]52,53], which is a relatively large fraction of our RM developed tumor recurrence in association with an increased rate of deaths.…”

Section: Clinical Histopathologic and Genetic Features Of Our Retrosp...supporting

confidence: 88%

Clinical, Histopathologic and Genetic Features of Rhabdoid Meningiomas

Ruiz

González-Tablas

Peña

et al. 2023

IJMS

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Rhabdoid meningiomas (RM) shows heterogeneous histological findings, and a wide variety of chromosomal copy number alterations (CNA) are associated with an unpredictable course of the disease. In this study, we analyzed a series of 305 RM samples from patients previously reported in the literature and 33 samples from 23 patients studied in our laboratory. Monosomy 22-involving the minimal but most common recurrent region loss of the 22q11.23 chromosomal region was the most observed chromosomal alteration, followed by losses of chromosomes 14, 1, 6, and 19, polysomies of chromosomes 17, 1q, and 20, and gains of 13q14.2, 10p13, and 21q21.2 chromosomal regions. Based on their CNA profile, RM could be classified into two genetic subgroups with distinct clinicopathologic features characterized by the presence of (1) chromosomal losses only and (2) combined losses and gains of several chromosomes. The latter displays a higher frequency of WHO grade 3 tumors and poorer clinical outcomes.

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Section: Clinical Histopathologic and Genetic Features Of Our Retrosp...supporting

confidence: 88%

Clinical, Histopathologic and Genetic Features of Rhabdoid Meningiomas

Ruiz

González-Tablas

Peña

et al. 2023

IJMS

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“…RM has first been described in 1978 by Beckwith and Palmer [15] and was reported to present multiple similarities with aggressive renal tumours and associated to a poor outcome. RM is histologically defined by the presence of abundant eosinophilic cytoplasm, eccentric nuclei, and intracytoplasmic hyaline inclusions [16,17]. Rhabdoid cells by themselves are not anaplastic only if they show signs Paediatric Rhabdoid Meningioma: Clinical and Therapeutic Features Findings of necrosis, high mitosis, atypia, sheeting, elevated MIB-1, and brain invasion.…”

Section: Discussionmentioning

confidence: 99%

Paediatric Rhabdoid Meningioma: Clinical and Therapeutic Features Findings – Case Series of 3 Patients

Gader,

Slimane,

Sliti

et al. 2023

Pediatr Neurosurg

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Introduction: Pediatric Rhabdoid Meningioma (RM) are the rarest, but most aggressive subtypes of meningioma, related to a severe prognosis. They account for 1-3% of all intracranial meningiomas. Case presentations: We report an institutional experience of 3 cases through which we discuss clinical, histological and therapeutic features of this tumour. Two of our patients were female-gendered (3 years old and 1 year and 6 months old), and one male-gendred (16 years old). Revealing symptoms were related to intracranial hypertension, cerebellar syndrome, cranial nerves palsy and skull tumefaction. Imaging showed extra-axial tumor located in the right Ponto-cerebellar angle in the first case, in the left occipital region in the second case, left parietal tumor in the third case. All patients underwent a surgical intervention with a gross total resection. Histological evaluation supported by immune-histochemistry confirmed the diagnosis of RM. Tumor recurrence was observed at 45 days in the first case with a fatal outcome. Despite adjuvant radiotherapy, both second and third cases had local recurrence after a mean follow up of 1 month following the radiotherapy. Conclusions: RM are very aggressive tumours. Standardized therapeutic guidelines are still under debate as actual approaches are still inefficient to prevent quick recurrence and fatal outcome.

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“…There is still no unified standard for RM treatment. Radical surgery combined with radiotherapy is the main method of treatment and the key to prolonging survival ( 4 ). At present, some studies have pointed out that cytotoxic drugs have certain efficacy and clinical value for aggressive meningiomas, but the evidence is limited ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

“…Thus, meningiomas are associated with a usually benign clinical outcome. Rhabdoid meningiomas (RMs) are a rare tumour subtype of meningiomas accounting for 1% to 3% of all intracranial meningiomas ( 1 , 3 , 4 ), and they usually present with unique histopathologic characteristics and were first reported in 1998 ( 5 , 6 ). In the WHO 2021 classification of CNS tumours, RM is defined based on the presence of rhabdoid cells and is classified as a WHO grade 3 tumour ( 1 ).…”

Section: Introductionmentioning

confidence: 99%

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Rhabdoid meningioma with a history of Budd-Chiari syndrome: a case report and review of the literature

Zeng

Zhang

et al. 2023

Front. Oncol.

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BackgroundRhabdoid meningioma and Budd-Chiari syndrome are both extremely rare, and there is no report describing the two diseases occurring in the same patient thus far. Herein, we showed an unusual case of rhabdoid meningioma with a history of Budd-Chiari syndrome.Case presentationThe man was found to have abnormal liver function during physical examination in 2016 at 36 and was not paid attention to it. In 2019, he went to Beijing YouAn Hospital Affiliated to Capital Medical University for the decompensation of cirrhosis and was diagnosed with Budd-Chiari syndrome, subsequent angiography of the inferior vena cava combined with balloon dilatation were performed, the anticoagulation and hepatoprotective therapy were performed for a long time. When he turned 40 who had magnetic resonance imaging (MRI) that showed a left frontotemporal lobe space-occupying lesion, and postoperative pathological examination confirmed rhabdoid meningioma. He underwent surgery and postoperative adjuvant radiotherapy, but then he developed severe psychiatric symptoms and eventually succumbed to a lung infection two months after treatment.ConclusionsBudd-Chiari syndrome and Rhabdoid meningiomas are both extremely rare diseases. To the best of our knowledge, there is no report that the two rare diseases occurred in the same patient, and this is the first case. However, whether there is any link between the two diseases is unclear, more researches are needed to confirm it in the future.

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Pediatric Rhabdoid Meningioma with Extension to the Heart: A First Case Report and Literature Review

Cited by 3 publications

References 22 publications

Clinical, Histopathologic and Genetic Features of Rhabdoid Meningiomas

Clinical, Histopathologic and Genetic Features of Rhabdoid Meningiomas

Paediatric Rhabdoid Meningioma: Clinical and Therapeutic Features Findings – Case Series of 3 Patients

Rhabdoid meningioma with a history of Budd-Chiari syndrome: a case report and review of the literature

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