Pediatric sleep questionnaire (PSQ): validity and reliability of scales for sleep-disordered breathing, snoring, sleepiness, and behavioral problems

Chervin, Ronald D.; Hedger, Kristen; Dillon, James E.; Pituch, Kenneth

doi:10.1016/s1389-9457(99)00009-x

Cited by 1,216 publications

(1,095 citation statements)

References 25 publications

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“…Other outcomes included caregiver and teacher ratings of behavior (Conners' Rating Scale Revised: Long Version Global Index, comprising Restless-Impulsive and Emotional Lability factor sets [caregiver-rated T scores range from 38 to 90, and teacher-rated T scores range from 40 to 90, with higher scores indicating worse functioning]), 12 and the Behavior Rating Inventory of Executive Function [BRIEF] Global Executive Composite T score, comprising summary measures of behavioral regulation and metacognition [caregiver-rated scores range from 28 to 101, and teacher-rated scores range from 37 to 131, with higher scores indicating worse functioning]) 13 ; symptoms of the obstructive sleep apnea syndrome, as assessed by means of the Pediatric Sleep Questionnaire sleep-related breathing disorder scale (PSQ-SRBD), in which scores range from 0 to 1, with higher scores indicating greater severity 14 ; sleepiness, as assessed with the use of the Epworth Sleepiness Scale modified for children, in which scores range from 0 to 24, with higher scores indicating greater daytime sleepiness 15 ; global quality of life (caregiver-rated total score from the Pediatric Quality of Life Inventory [PedsQL], in which scores range from 0 to 100, with higher scores indicating better quality of life) 16 ; disease-specific quality of life (total score on the 18-item Obstructive Sleep Apnea-18 assessment tool, in which scores range from 18 to 126, with higher scores indicating worse quality of life) 17 ; generalized intellectual functioning (General Conceptual Ability score from the Differential Ability Scales-II [DAS], in which scores range from 30 to 170, with higher scores indicating better functioning) 18 ; and polysomnographic indexes.…”

Section: Discussionmentioning

confidence: 99%

A Randomized Trial of Adenotonsillectomy for Childhood Sleep Apnea

Marcus

Moore

Rosen

et al. 2014

Survey of Anesthesiology

229

438

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BACKGROUND-Adenotonsillectomy is commonly performed in children with the obstructive sleep apnea syndrome, yet its usefulness in reducing symptoms and improving cognition, behavior, quality of life, and polysomnographic findings has not been rigorously evaluated. We hypothesized that, in children with the obstructive sleep apnea syndrome without prolonged oxyhemoglobin desaturation, early adenotonsillectomy, as compared with watchful waiting with supportive care, would result in improved outcomes.

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Section: Discussionmentioning

confidence: 99%

A Randomized Trial of Adenotonsillectomy for Childhood Sleep Apnea

Marcus

Moore

Rosen

et al. 2014

Survey of Anesthesiology

229

438

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“…Thus, the main aims of the present study were twofold: First, to compare the prevalence of SDB and EDS among adolescent girls with PCOS with sex-, age-, race-, and BM-Z scorematched controls using standardized questionnaires [10] [11] Second, to evaluate the association of SDB and EDS with anthropometrics, demographics, metabolic, and endocrine profiles derived from electronic medical records, within the PCOS group.…”

Section: Introductionmentioning

confidence: 99%

Screening For Sleep Disordered Breathing And Excessive Daytime Sleepiness in Adolescent Girls With Polycystic Ovarian Syndrome

Nandalike

Agarwal

Coupey

et al. 2010

D74. Clinical Presentation and Epidemiology of Sleep Disordered Breathing

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Objective-To determine the prevalence and clinical and metabolic correlates of sleep disordered breathing (SDB) and excessive daytime sleepiness (EDS) in adolescent girls with polycystic ovarian syndrome (PCOS).Study design-Standardized questionnaires were administered to subjects with PCOS and age-, sex-, ethnicity-, and BMI Z-score-matched controls. Medical records were reviewed for anthropometric and metabolic data.Results-We studied 103 subjects with PCOS (16.9±1.5 years) and 90 controls (16.8±1.7 years). Compared with controls, girls with PCOS had a higher prevalence of SDB (45.6% vs. 27.8%, p=0.01) and EDS (54.4% vs.35.6%, p<0.01). Within PCOS, those with SDB had higher BMI Zscore (2.1±0.5 vs.1.7±0.6, p< 0.01), higher homeostatic model assessment (HOMA) (5.1±2.3 vs. 4.1±3.5, p<0.01), and higher prevalence of the metabolic syndrome (MetS) (42.6% vs. 16.1%, p=0.003), compared with those without SDB. Similarly, subjects with PCOS and EDS had higher BMI-Z score (2.0±0.6 vs.1.7±0.6, p=0.03), higher HOMA (5.1±2.9 vs.3.8±3.1, p=0.01), and higher rate of MetS (39.3% vs. 14.9% p<0.01), compared with those without EDS. MetS was independently associated with SDB (OR 3.2, CI-1.0-10.1) and EDS (OR 4.5, CI-1.2-16).Conclusions-SDB and EDS are highly prevalent in adolescent girls with PCOS compared with matched controls. The MetS is independently associated with SDB and EDS in this group. The preliminary results of this paper were presented at ATS 2010 International Meeting.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. In recent years, PCOS has also been recognized to be associated with sleep disordered breathing (SDB) as well as excessive daytime sleepiness (EDS) [4,5]. In fact, a prospective case-control study, estimated that women with PCOS have a 30-fold higher prevalence of SDB than women in the general population [5]. The pathophysiological mechanisms leading to such high prevalence of SDB in PCOS have not yet been defined. However, possible causes include alterations in body fat composition due to excess androgen levels and/or the effects of metabolic syndrome [4,6], the later of which has been previously associated with increased risk of SDB in patients without PCOS [7,8]. Even though SDB is very prevalent in women with the disorder, the natural history of the disorder in adolescent girls and young women is unknown, mostly due to lack of knowledge about such an association. [9]. NIH Public AccessThus, the main aims of the present study were twofold: First, to compare the prevalence of SDB and EDS among adolescent girls with PCOS with sex-, age-, race-, and BM-Z sc...

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“…Children were categorized to OSA group if any of the following criteria were met: history of snoring plus respiratory pauses during sleep lasting more than 10 s or daytime drowsiness with history of sleep-disordered breathing, or positive response to at least eight of the 22 questions in the pediatric sleep questionnaire [14,15]. Anesthesia was induced with administration of sevoflurane followed by a propofol (2 mg/kg) bolus to achieve anesthesia and facilitate endotracheal intubation.…”

Section: Participants and Standard Anesthetic Proceduresmentioning

confidence: 99%

OCT1 Genetic Variants are Associated with Postoperative Morphine-Related Adverse Effects in Children

et al. 2017

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Aim: Large interindividual variability in morphine pharmacokinetics (PK) could contribute to variability in morphine analgesia and adverse events. Respiratory depression (RD) and postoperative nausea and vomiting (PONV) are significant adverse drug response of intravenous morphine in the perioperative setting limiting its efficacy in achieving adequate surgical pain relief. OCT1 is a transporter in the liver that transports morphine from the bloodstream into hepatocytes. Earlier we reported association of genetic polymorphisms in OCT1 with morphine PK, and lower morphine clearance in Caucasian children as compared with African–American (AA) children. The aim of this study is to identify the association between common OCT1 genotypes affecting morphine’s PK and clinically important postoperative morphine-related adverse outcomes. Methods: After obtaining institutional review board (IRB) approval and informed consents, 311 children ages 6–15 years, American Society of Anesthesiologists’ physical status 1 or 2 scheduled for tonsillectomy who received standard anesthetic, surgical and postoperative care were recruited. Clinical data collected included postoperative pain scores, total opioid use, incidence of PONV and RD. Four nonsynonymous SNPs of the OCT1 gene (rs12208357, rs34130495, rs72552763 and rs34059508) in each patient were genotyped using commercially available TaqMan assays. We investigated the genetic association of OCT1 with incidences of postoperative RD and PONV. Results: Caucasian and AA children differed significantly in the incidence of obstructive sleep apnea (p < 0.001) and total morphine use (p = 0.028). There were incidences of prolonged post anesthesia care unit stay in 7% of Caucasian children, while no such incidences were observed for AA children (p = 0.05). OCT1 polymorphism rs12208357 was associated with high incidences of PONV and PONV leading to prolonged post anesthesia care unit stay (p < 0.05). A significant association was also found between rs72552763 GAT deletion and high incidence of RD (p = 0.007). Conclusion: Children with certain OCT1 genotypes are associated with higher risk for RD and PONV following morphine administration leading to prolonged hospital stay. The OCT1 transporters’ effects on morphine’s PK could explain this association.

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Pediatric sleep questionnaire (PSQ): validity and reliability of scales for sleep-disordered breathing, snoring, sleepiness, and behavioral problems

Cited by 1,216 publications

References 25 publications

A Randomized Trial of Adenotonsillectomy for Childhood Sleep Apnea

A Randomized Trial of Adenotonsillectomy for Childhood Sleep Apnea

Screening For Sleep Disordered Breathing And Excessive Daytime Sleepiness in Adolescent Girls With Polycystic Ovarian Syndrome

OCT1 Genetic Variants are Associated with Postoperative Morphine-Related Adverse Effects in Children

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