Pediatric stroke associated with a sedentary lifestyle during the SARS-CoV-2 (COVID-19) pandemic: a case report on a 17-year-old

Lam, Keng; Lee, Jonathan H.; Cheng, Pengfei; Ajani, Zahra; Salem, Morris; Sangha, Navdeep

doi:10.1007/s10072-020-04857-w

Cited by 11 publications

(9 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…COVID-19 pandemic-associated quarantine has taken the population to develop or enhance a sedentary lifestyle, and this can be seen even in teenagers [35]. It is known that the regular practice of physical exercises acts as a modulator of the immune system lowering the incidence, intensity of symptoms, and mortality in viral infections, which can be observed in people who are physically active [36].…”

Section: Physical Exercise and Mental Health During The Pandemicmentioning

confidence: 99%

Physical exercise effects on the brain during COVID-19 pandemic: links between mental and cardiovascular health

et al. 2021

View full text Add to dashboard Cite

The current pandemic was caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The quarantine period during corona virus disease 19 (COVID-19) outbreak might affect the quality of life leading thousands of individuals to diminish the daily caloric expenditure and mobility, leading to a sedentary behavior and increase the number of health disorders. Exercising is used as a non-pharmacological treatment in many chronic diseases. Here, we review the molecular mechanisms of physical exercise in COVID-19 pandemic on mental health. We also point links between exercise, mental, and cardiovascular health. The infection caused by SARS-CoV-2 affects host cells binding to angiotensin-converting enzyme-2 (ACE2), which is the receptor for SARS-CoV-2. If there is not enough oxygen supply the lungs and other tissues, such as the heart or brain, are affected. SARS-CoV-2 enhances ACE2 leading to inflammation and neuronal death with possible development of mood disorders, such as depression and anxiety. Physical exercise also enhances the ACE2 expression. Conversely, the activation of ACE2/Ang 1-7/Mas axis by physical exercise induces an antiinflammatory and antifibrotic effect. Physical exercise has beneficial effects on mental health enhancing IGF-1, PI3K, BDNF, ERK, and reducing GSK3β levels. In addition, physical exercise enhances the activity of PGC-1α/ FNDC5/Irisin pathway leading to neuronal survival and the maintenance of a good mental health. Thus, SARS-CoV-2 infection leads to elevation of ACE2 levels through pathological mechanisms that lead to neurological and cardiovascular complications, while the physiological response of ACE2 to physical exercise improves cardiovascular and mental health.

show abstract

Section: Physical Exercise and Mental Health During The Pandemicmentioning

confidence: 99%

Physical exercise effects on the brain during COVID-19 pandemic: links between mental and cardiovascular health

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Based on current knowledge, several possible mechanisms exist, including hypercoagulability, activation of the cytokine storm, excessive levels of antiphospholipid antibodies, and abnormal ferritin levels. During the lockdown period, factors such as lifestyle changes and sedentary lifestyle must be taken into consideration when assessing stroke risks [118]. It is unclear whether the patients who recover from COVID-19-related stroke experience any transient or long-lasting cerebrovascular sequelae.…”

Section: Discussionmentioning

confidence: 99%

Ischemic Stroke: An Underestimated Complication of COVID-19

Cao¹,

Zhang²,

Wang³

et al. 2021

Aging and disease

View full text Add to dashboard Cite

The coronavirus disease 2019 (COVID-19) has spread rapidly as a pandemic around the world. In addition to severe acute respiratory syndrome, more and more studies have focused on the complication of COVID-19, especially ischemic stroke. Here, we propose several pathophysiological processes and possible mechanisms underlying ischemic stroke after COVID-19 for early prevention and better treatment of COVID-19-related stroke.

show abstract

“…It can be assumed that overtraining or prolonged exercise training may lead to pessimistic health conditions such as mood disorders[ 20 ]. The quarantine associated with COVID-19 may increase the development of a sedentary lifestyle among different populations including adolescents[ 26 ]. Regular exercise training improves immune function, lowers the severity of symptoms, and reduces the mortality rate in individuals exposed to viral infection[ 10 ].…”

Section: Physical Activity and Mental Healthmentioning

confidence: 99%

Physical activity and mental well-being during COVID-19 pandemic

Abdelbasset¹,

Nambi²,

Eid³

et al. 2021

WJP

View full text Add to dashboard Cite

The corona virus disease 2019 (COVID-19) pandemic has resulted in most nations deciding upon self-isolation and social distancing policies for their citizens to control the pandemic and reduce hospital admission. This review aimed at evaluating the effect of physical activity on mental well-being during the COVID-19 pandemic. It was concluded that the COVID-19 pandemic may lead to augmented levels of angiotensin-converting enzyme (ACE)-2 that led to cardiovascular and neurological disorders associated with highly inflammatory effects of viral infection affecting the brain tissues leading to damage of the nervous system and resulting in cognition dysfunction, insulin sensitivity reduction, and behavioral impairments. Anxiety and depression may lead to negative effects on various quality of life domains, such as being physically inactive. Regular physical activities may reduce inflammatory responses, improve ACE-2 responses, and improve mental well-being during self-isolation and social distancing policies related to the COVID-19 pandemic. Further studies should be conducted to assess the different intensities of physical activities on cardiovascular function, and mental well-being during the COVID-19 pandemic.

show abstract

Pediatric stroke associated with a sedentary lifestyle during the SARS-CoV-2 (COVID-19) pandemic: a case report on a 17-year-old

Cited by 11 publications

References 11 publications

Physical exercise effects on the brain during COVID-19 pandemic: links between mental and cardiovascular health

Physical exercise effects on the brain during COVID-19 pandemic: links between mental and cardiovascular health

Ischemic Stroke: An Underestimated Complication of COVID-19

Physical activity and mental well-being during COVID-19 pandemic

Contact Info

Product

Resources

About