Pediatric thyroid cancer: An update from the SEER database 2007–2012

Dermody, Sarah M.; Walls, Andrew; Harley, Earl H.

doi:10.1016/j.ijporl.2016.08.005

Cited by 90 publications

(81 citation statements)

References 10 publications

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“…Notably, the most frequent location of rhabdomyosarcomas is the head and neck region and accounts for more than 5% of all pediatric cancers . Worldwide, an increase of thyroid cancer for both children, adolescents, and adults has been reported, mainly explained by the increase in papillary carcinomas among females . Thyroid cancer is rare in children under the age of 15 years, with a reported incidence rate below 0.4% per 100,000 reported patients .…”

Section: Discussionmentioning

confidence: 99%

“…Since 12% of all pediatric cancer cases are located in the head and neck, knowledge of age‐specific incidence rates and tumor location and histology is important . Previous studies have reported an increasing incidence of pediatric malignancies, though available reports focus on general pediatric populations from cohorts diagnosed 20 or more years ago, part‐population‐based studies, or specific types of cancer (for example, thyroid cancer or sarcomas). It remains unclear whether head and neck pediatric malignancies are increasing in incidence and if so, whether particular cancer types are responsible for the increase.…”

Section: Introductionmentioning

confidence: 99%

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Incidence of head and neck cancer in children: A Danish nationwide study from 1978 to 2014

Larsen

Hjalgrim

Jakobsen

et al. 2018

Pediatric Blood & Cancer

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Incidence of head and neck cancer in children: A Danish nationwide study from 1978 to 2014

Larsen

Hjalgrim

Jakobsen

et al. 2018

Pediatric Blood & Cancer

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“…To accurately characterize demographic, clinical, and survival aspects of a rare childhood malignancy, large cohort studies are often necessary, as single and multicenter approaches lack appropriate sample sizes. The SEER database has previously been used for these reasons to gain power through cohort approaches to study both pediatric and adult head and neck malignancies . As of the most recent November 2015 update to the SEER database, over 9 million cases have been pooled from 14 population‐based cancer registries and three supplemental registries covering approximately 28% of the US population…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and outcomes of major salivary gland malignancies in children

2017

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“…The rarity of pediatric DTC, the lack of information on histologic features, or both have prevented prior studies from analyzing trends by tumor size or cancer stage at diagnosis . The only prior study to examine DTC trends during 1984‐2010 by tumor size in children and young adults included patients 30 years old or younger.…”

Section: Introductionmentioning

confidence: 99%

Trends in pediatric thyroid cancer incidence in the United States, 1998‐2013

Bernier

Withrow

González

et al. 2019

Cancer

101

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Background Pediatric differentiated thyroid cancer (DTC) rates have increased over time in the United States and worldwide. Improvements in imaging for the diagnosis of DTC have been hypothesized as a potential driver of these increases. This study stratifies temporal trends in pediatric DTC by stage and tumor size to assess whether rates of large, late‐stage cancers, which are likely to be clinically meaningful, are increasing over time. Methods Age‐standardized incidence rates (ASRs) of DTC and annual percent changes (APCs) in primary DTC rates were estimated for 0‐ to 19‐year‐olds with data from 39 US cancer registries during 1998‐2013. Results During 1998‐2013, 7296 cases of DTC were diagnosed (6652 papillary cases and 644 follicular cases). APCs of pediatric DTCs significantly increased by 4.43%/y [95% CI, 3.74%/y‐5.13%/y], primarily because of increases in papillary histologies. Increasing trends were observed for children aged 10 to 19 years for both sexes and for non‐Hispanic whites, non‐Hispanic blacks, and Hispanics. Rates increased significantly over the time period for all tumor stages (APClocalized, +4.06%/y [95% CI, 2.84%/y‐5.29%/y]; APCregional, +5.68%/y [95% CI, 4.64%/y‐6.73%/y]; APCdistant, +8.55%/y [95% CI, 5.03%/y‐12.19%/y]) and across tumor sizes (APC<1 cm, +9.46%/y [95% CI, 6.13%/y‐12.90%/y]; APC1‐2 cm, +6.92%/y [95% CI, 4.31%/y‐9.60%/y]; APC>2 cm, +4.69%/y [95% CI, 2.75%/y‐6.67%/y]). Conclusions Significantly increasing rates of DTC over time among 10‐ to 19‐year‐olds in the United States are unlikely to be entirely explained by increases in medical surveillance during childhood because rates of large and late‐stage DTC are increasing over time. Future studies should examine environmental and other factors that may be contributing to rising DTC rates.

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Pediatric thyroid cancer: An update from the SEER database 2007–2012

Cited by 90 publications

References 10 publications

Incidence of head and neck cancer in children: A Danish nationwide study from 1978 to 2014

Incidence of head and neck cancer in children: A Danish nationwide study from 1978 to 2014

Clinical characteristics and outcomes of major salivary gland malignancies in children

Trends in pediatric thyroid cancer incidence in the United States, 1998‐2013

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