Pediatric Thyroid Carcinoma: Incidence and Outcomes in 1753 Patients

Overview of Carcinomas in Adolescents: A Descriptive Study Over Twenty Years

“…Five-years EFS and OS rates of thyroid carcinomas were 88.3% and 100% respectively, comparable to that reported by the SEER registry (98% 5-y OS and 91% 30-y OS) [12]. Histology distribution and distant metastasis rate were also similar, but lymph node involvement was more frequent in our series (68% vs. 46.4%) which may be related to lymph node dissection routinely performed in our institution.…”

“…Only 2/7 patients with FL-HCC and 1/5 HCC were alive with a follow-up of 47, 77 and 74 months but after multiple recurrences treated with various combined therapies (multiple surgeries, chemotherapy, hyperthermic intraperitoneal chemotherapy, inhibitor tyrosine kinase, radiofrequency). The median survival of patients was 26 months (12-78) for FL-HCC and 16.5 months (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25) for HCC.…”

Pediatric Thyroid Cancers: An Indian Perspective

“…Samuels et al from Radiation Medicine Center (RMC), Mumbai found that pediatric DTC comprised 3% of all DTCs at their center [10].More contemporary knowledge about this rare entity has come from the recent analysis of the Surveillance, Epidemiology, and End Results (SEER) registry from 1973 to 2004, which found an age-adjusted annual incidence of 0.54 cases per 100,000 persons in USA [1].There have been no population based studies on this disease from India.…”

“…Thyroid cancer is even rarer below 10 years of age, with an estimated incidence of about 1 per million [1].Adolescents have a 10-fold greater incidence than younger children [1].The gender ratio is same for pre-pubertal boys and girls, while after puberty,girls are four to five times more likely to have thyroid cancer than boys [1,11]. Similar gender distribution was also found in the Indian studies [3,9,10].We found that the gender ratio was almost equal (1:1.5) in the pre-pubertal age group, whereas girls were three times more commonly involved in the post-pubertal age group [3].…”

“…Pediatric thyroid cancer is a rare entity that is treatable with an excellent prognosis [1]. In spite of the fact that as compared to its adult counterpart pediatric differentiated thyroid cancer (DTC) presents at an advanced stage and has higher recurrence rates, mortality due to the disease is rare [2].…”