Pediatric-to-adult Transition and Medication Adherence in Patients with Inflammatory Bowel Disease

Jeganathan, Jayson; Lee, Cheng Hiang; Rahme, Antony; Tiao, Darren K; Weston, Celine; Dutt, Shoma; Magoffin, Annabel; Kwan, Vu; Alswaifi, Aladdin; Katelaris, Peter; Gaskin, Kevin; O’Loughlin, Edward; Leong, Rupert W.

doi:10.1097/mib.0000000000001114

Cited by 22 publications

(26 citation statements)

References 21 publications

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“…Indeed, it has recently been reported that pharmacists can have a major role in monitoring treatment plans and adverse events in biological treatment of rheumatological, gastroenterological, and dermatological pathologies [38]. Indeed, in patients with inflammatory bowel diseases, nonadherence to medication can be improved through pharmacist counseling [39,40]. Lastly, having a pharmacist involved in the clinical management of biological agents is believed to enhance the overall team model of patient care [41].…”

Section: Role Of the Pharmacistmentioning

confidence: 99%

Self-administration of omalizumab: why not? A literature review and expert opinion

Menzella

Ferrari²,

Ferrucci

et al. 2021

Expert Opinion on Biological Therapy

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Introduction: Omalizumab is used to treat severe uncontrolled allergic asthma and chronic spontaneous urticaria (CSU), and is approved for self-administration in prefilled syringes. It is thus important to understand the advantages, critical issues, and indications for home administration. Areas covered: The present review summarizes the available evidence on home administration of omalizumab in asthma and CSU to illustrate the advantages derived from self-administration of patients in this setting. Expert opinion: The available data suggest that patients can safely administer biologics at home with suitable training, and that home administration is time saving and cost-effective. The majority of patients with severe asthma or CSU treated with omalizumab are likely to be suitable candidates for self-administration, which can be proposed to anyone that the clinician deems suitable. In addition to clinicians, pharmacists can also play a key role in managing patients who are prescribed home administration. A practical flow chart is proposed on selection of patients and their management during home administration. Self-administration of biologics can be considered as a valid alternative to traditional injections in a clinical setting, and the evidence has shown that no major issues need to be overcome in terms of safety or efficacy.

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Section: Role Of the Pharmacistmentioning

confidence: 99%

Self-administration of omalizumab: why not? A literature review and expert opinion

Menzella

Ferrari²,

Ferrucci

et al. 2021

Expert Opinion on Biological Therapy

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“…[53](Figure 2) The pronounced symptomology of diarrhoea and abdominal pain may favour medical adherence in adolescents with IBD, as opposed to other asymptomatic conditions. [54] It may be a challenge to achieve a "treat to target" approach by objective non-invasive monitoring using biomarkers such as FC, although that approach may be partially accepted in patients with mild symptoms.…”

Section: Perspectives and Barriers To Transition Carementioning

confidence: 99%

“…Jeganathan et al [54], in a cross-sectional cohort study, investigated adherence to medication using the In a relatively small study from Germany, structured transition of adolescents into adult health care led to relevant clinical and economic benefits. An important observation of this study was that delayed puberty was only noted in the group that transferred without structured transition.…”

Section: Why Do We Need a Transition Programme? Advantages Of Transitionmentioning

confidence: 99%

Can a transition clinic bridge the gap between paediatric and adult inflammatory bowel disease care models?

Nardone

Iacucci

Ghosh

et al. 2020

Digestive and Liver Disease

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Link to publication on Research at Birmingham portal General rightsUnless a licence is specified above, all rights (including copyright and moral rights) in this document are retained by the authors and/or the copyright holders. The express permission of the copyright holder must be obtained for any use of this material other than for purposes permitted by law.• Users may freely distribute the URL that is used to identify this publication.• Users may download and/or print one copy of the publication from the University of Birmingham research portal for the purpose of private study or non-commercial research.• User may use extracts from the document in line with the concept of 'fair dealing' under the Copyright, Designs and Patents Act 1988 (?) • Users may not further distribute the material nor use it for the purposes of commercial gain.Where a licence is displayed above, please note the terms and conditions of the licence govern your use of this document.When citing, please reference the published version. Take down policyWhile the University of Birmingham exercises care and attention in making items available there are rare occasions when an item has been uploaded in error or has been deemed to be commercially or otherwise sensitive.

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“…If done poorly, transition can affect not only the use of health services but also the patient’s health [89]. Although there have been few studies on patients with IBD, implementing an effective transition care program can help improve patients’ medication adherence and their health and life outcomes while promoting self-reliance [89,90].…”

Section: Outcomes Of Transitionmentioning

confidence: 99%

Successful transition from pediatric to adult care in inflammatory bowel disease: what is the key?

Kim

2019

Intest Res

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The incidence of pediatric-onset inflammatory bowel disease (IBD) is on the rise, accounting for up to 25% of IBD cases. Pediatric IBD often has extensive bowel involvement with aggressive and rapidly progressing behavior compared to adult IBD. Because IBD has a high morbidity rate and can have a lifelong impact, successful transition from pediatric to adult care is important to maintain the continuity of care. Furthermore, successful transition facilitates appropriate development and psychosocial well-being among patients, as well as comprehensive and harmonious healthcare delivery amongst stakeholders. However, there are various obstacles related to patients, family, providers, and organizations that interfere with successful transition. Successful transition requires a flexible and tailored plan that is made according to the patient’s developmental abilities and situation. This plan should be established through periodic interviews with the patient and family and through close collaboration with other care providers. Through a stepwise approach to the transition process, patients’ knowledge and self-management skills can be improved. After preparation for the transition is completed and the obstacles are overcome, patients can be gradually moved to adult care. Finally, successful transition can increase patients’ adherence to therapy, maintain the appropriate health status, improve patients’ self-management, and promote self-reliance among patients.

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Pediatric-to-adult Transition and Medication Adherence in Patients with Inflammatory Bowel Disease

Cited by 22 publications

References 21 publications

Self-administration of omalizumab: why not? A literature review and expert opinion

Self-administration of omalizumab: why not? A literature review and expert opinion

Can a transition clinic bridge the gap between paediatric and adult inflammatory bowel disease care models?

Successful transition from pediatric to adult care in inflammatory bowel disease: what is the key?

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