2024
DOI: 10.1177/10732748241270564
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Pediatric Tumors as Disorders of Development: The Case for In Vitro Modeling Based on Human Stem Cells

Cullen D. Clairmont,
Joanna J. Gell,
Ching C. Lau

Abstract: Despite improvements in patient outcomes, pediatric cancer remains a leading cause of non-accidental death in children. Recent genetic analysis of patients with pediatric cancers indicates an important role for both germline genetic predisposition and cancer-specific somatic driver mutations. Increasingly, evidence demonstrates that the developmental timepoint at which the cancer cell-of-origin transforms is critical to tumor identity and therapeutic response. Therefore, future therapeutic development would be… Show more

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