Pediatric Vaccines and Cost-Effectiveness Thresholds: How Much is Too Much to Pay for Prevention?

Amdahl, Jordan; Weycker, Derek; Farkouh, Ray; Huang, Liping; Eichten, Caitlin; Oster, Gerry

doi:10.1007/s40121-020-00367-6

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The Need To Articulate the Value Of A Vaccine: General Consi...1

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2024

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“…A valuable vaccine may be expected to exhibit high (≥80%) efficacy against what is typically a clinical endpoint whose etiology is defined microbiologically or, increasingly, molecularly. An additional element of value is a costeffectiveness ratio that sits within a somewhat arbitrary range of acceptability [8].…”

Section: The Need To Articulate the Value Of A Vaccine: General Consi...mentioning

confidence: 99%

What Drives the Value of a Shigella Vaccine?

2022

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The development and licensure of a safe and highly efficacious Shigella vaccine has been a priority in international public health circles for decades and would represent a great scientific achievement. Nonetheless, in the context of increasingly crowded and costly childhood immunization programs, and with a myriad of other new and improved vaccines currently or soon on the market, there is no guarantee that even a highly effective Shigella vaccine would become a priority for adoption and introduction by the low- and middle-income countries that could benefit from it the most. We discuss here some of the major determinants and questions regarding the introduction of Shigella vaccines and the importance of developing a succinct, compelling public health value proposition.

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Section: The Need To Articulate the Value Of A Vaccine: General Consi...mentioning

confidence: 99%