Pediatric Warthin-like Mucoepidermoid Carcinoma: Report of Two Cases with One Persistent/Recurrent as Conventional Mucoepidermoid Carcinoma

Daoud, Elena V; McLean-Holden, Anne C.; Pfeifer, Cory M.; Timmons, Charles F.; Oliai, Bahram R.; Bishop, Justin A.

doi:10.1007/s12105-020-01156-w

Cited by 9 publications

(17 citation statements)

References 24 publications

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“…There were no obvious regional or nationality preferences. These clinical characteristics are similar to those of conventional MEC, which is more likely to occur in females and may affect the paediatric population ( 1 , 15 ). Radiological features were available for nine cases: Ultrasonography ( 9 , 11 ) and computed tomography ( 8 , 10 , 15 ) revealed a well-circumscribed tumour with multiple cysts.…”

Section: Discussionsupporting

confidence: 57%

“…These clinical characteristics are similar to those of conventional MEC, which is more likely to occur in females and may affect the paediatric population ( 1 , 15 ). Radiological features were available for nine cases: Ultrasonography ( 9 , 11 ) and computed tomography ( 8 , 10 , 15 ) revealed a well-circumscribed tumour with multiple cysts. Magnetic resonance imaging displayed a low- or intermediate-intensity tumour ( 10-12 , 15 ).…”

Section: Discussionsupporting

confidence: 57%

“…The present study reported the sixth cytological Warthin-like MEC case. To the best of our knowledge, only 22 cases, including the present case, have been reported since the first report by Ishibashi et al (3) in 2015 (8)(9)(10)(11)(12)(13)(14)(15). Table I summarizes the clinicopathological features of Warthin-like MEC.…”

Section: Discussionmentioning

confidence: 81%

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Fine‑needle aspiration cytology of Warthin‑like mucoepidermoid carcinoma: A case report with cytological review

et al. 2021

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Section: Discussionsupporting

confidence: 57%

Section: Discussionsupporting

confidence: 57%

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Fine‑needle aspiration cytology of Warthin‑like mucoepidermoid carcinoma: A case report with cytological review

et al. 2021

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“…19 Recently, a new variant of MEC (low-grade MEC with tumor-associated lymphoid proliferation) was described in the literature, showing CRTC1-MAML2 gene fusion. [20][21][22][23][24][25][26][27] For this special variant of MEC, a misdiagnosis with other tumors can occur because the tumor is composed of bilayered but not overtly oncocytic cells with dense reactive lymphoid proliferation. Owing to a smaller number of cases reported on this specific variant, more detailed microscopic features need to be further recognized.…”

mentioning

confidence: 99%

Reevaluation of Salivary Lymphadenoma: A Subgroup Identified as Warthin-like Mucoepidermoid Carcinoma Following Molecular Investigation for MAML2 Rearrangement

Zhang

et al. 2020

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Both salivary lymphadenomas (LADs) and Warthin-like mucoepidermoid carcinoma (MEC) contain components of epithelium and lymphoid stroma and their differential diagnosis can be difficult on the basis of morphology alone. Objective.— To clarify whether Warthin-like MEC was diagnosed as a LAD, and to compare their clinicopathologic features. Design.— A total of 16 LAD cases were analyzed for MAML2 rearrangement by using fluorescence in situ hybridization, and the clinical, histologic, immunohistochemical, and prognostic features were compared between MAML2 rearrangement–positive and MAML2 rearrangement–negative groups. Results.— Among the 16 cases investigated, 9 harbored a MAML2 rearrangement and were reclassified as Warthin-like MEC. The remaining 7 cases were classified as LADs with 1 nonsebaceous and 6 sebaceous cases. The patients with Warthin-like MEC had a wider age range (10–75 years) than the patients with LADs (36–68 years). Histologically, 2 of the 9 Warthin-like MECs (22.2%) showed focal invasion, whereas all the LADs had complete capsules. Warthin-like MECs exhibited a diverse epithelial cell morphology, including basaloid, glandular, cuboidal, epidermoid, with mucinous cells, although these cytologic features were seen only focally in some cases. Nonsebaceous LAD was composed of basaloid and glandular epithelial cells predominantly. In sebaceous LAD, the epithelial cells were composed of basaloid and large foamy sebaceous cells. In all cases, the stroma was composed mainly of lymphocytes accompanied by lymphoid follicles, although plasma cell infiltration could be much heavier in Warthin-like MEC. All the patients had a good outcome after a longer follow-up (3∼166 months). Conclusions.— Warthin-like MEC can be misdiagnosed as a LAD owing to overlap in clinicopathologic features of the 2 entities. Careful histologic evaluation and detection of MAML2 rearrangement can facilitate their differential diagnosis.

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“…Both fusion products and EGF expression are used for diagnostic purposes to predict the outcome of the disease. FISH analysis of MALM2 rearrangement has been used to identify MEC in histological samples that strongly resembled Warthin’s tumor [ 81 , 82 ]. Chromosomal rearrangements have also been described in pleomorphic adenoma, such as the reciprocal translocations t (3;8) (p21;q12) resulting in promoter swapping between the zinc finger PLAG1 and the β-catenin gene [ 83 ].…”

Section: Cellular and Molecular Mechanisms At The Origin Of Salivamentioning

confidence: 99%

Molecular and Cellular Modelling of Salivary Gland Tumors Open New Landscapes in Diagnosis and Treatment

Porcheri

Meisel

Mitsiadis

2020

Cancers

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Salivary gland tumors are neoplasms affecting the major and minor salivary glands of the oral cavity. Their complex pathological appearance and overlapping morphological features between subtypes, pose major challenges in the identification, classification, and staging of the tumor. Recently developed techniques of three-dimensional culture and organotypic modelling provide useful platforms for the clinical and biological characterization of these malignancies. Additionally, new advances in genetic and molecular screenings allow precise diagnosis and monitoring of tumor progression. Finally, novel therapeutic tools with increased efficiency and accuracy are emerging. In this review, we summarize the most common salivary gland neoplasms and provide an overview of the state-of-the-art tools to model, diagnose, and treat salivary gland tumors.

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Pediatric Warthin-like Mucoepidermoid Carcinoma: Report of Two Cases with One Persistent/Recurrent as Conventional Mucoepidermoid Carcinoma

Cited by 9 publications

References 24 publications

Fine‑needle aspiration cytology of Warthin‑like mucoepidermoid carcinoma: A case report with cytological review

Fine‑needle aspiration cytology of Warthin‑like mucoepidermoid carcinoma: A case report with cytological review

Reevaluation of Salivary Lymphadenoma: A Subgroup Identified as Warthin-like Mucoepidermoid Carcinoma Following Molecular Investigation for MAML2 Rearrangement

Molecular and Cellular Modelling of Salivary Gland Tumors Open New Landscapes in Diagnosis and Treatment

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