Pedicle Periosteum as a Barrier for Guided Bone Regeneration in the Rabbit Frontal Bone

Hasuike, Akira; Ujiie, Hisashi; Senoo, Motoki; Furuhata, Mitsuaki; Kishida, Mamoru; Akutagawa, Hideyasu; Sato, Shuichi

doi:10.21873/invivo.11530

Cited by 10 publications

(8 citation statements)

References 16 publications

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“…[ 129 ] Biologic materials composed of mammalian ECM have been effectively used for the repair and reconstruction of a variety of tissues, including skeletal muscle, [ 130–132 ] esophagus, [ 133–135 ] and heart, [ 136–138 ] among others. Barrier membranes for GBR applications have been successfully fabricated using various biological sources, such as pedicle periosteum, [ 139 ] leukocyte‐ and platelet‐rich fibrin (L‐PRF), [ 140 ] and small intestinal submucosa (SIS). In particular, multilaminate small intestinal submucosa (mSIS) [ 141 ] consisted in a stack of eight lyophilized layers of acellular porcine SIS.…”

Section: Gbr Strategies and New Membranes Under Preclinical Evaluationmentioning

confidence: 99%

Membranes for Guided Bone Regeneration: A Road from Bench to Bedside

Aprile

Letourneur

Simón-Yarza

2020

Adv Healthcare Materials

123

119

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Bone resorption can negatively influence the osseointegration of dental implants. Barrier membranes for guided bone regeneration (GBR) are used to exclude nonosteogenic tissues from influencing the bone healing process. In addition to the existing barrier membranes available on the market, a growing variety of membranes for GBR with tailorable physicochemical properties are under preclinical evaluation. Hence, the aim of this review is to provide a comprehensive description of materials used for GBR and to report the main industrial and regulatory aspects allowing the commercialization of these medical devices (MDs). In particular, a summary of the main attributes defining a GBR membrane is reported along with a description of commercially available and under development membranes. Finally, strategies for the scaling-up of the manufacturing process and the regulatory framework of the main MD producers (USA, EU, Japan, China, and India) are presented. The description of the regulatory approval process of GBR membranes is representative of the typical path that medium-to high-risk MDs have to follow for an effective medical translation, which is of fundamental importance to increase the impact of biomedical research on public health.

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Section: Gbr Strategies and New Membranes Under Preclinical Evaluationmentioning

confidence: 99%

Membranes for Guided Bone Regeneration: A Road from Bench to Bedside

Aprile

Letourneur

Simón-Yarza

2020

Adv Healthcare Materials

123

119

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“…The inner osteogenic (cambium) layer, which lies adjacent to the bone, has a high cellular density, including osteoclasts. ( Frey, et al, 2013 , Hasuike et al, 2019 )…”

Section: Discussionmentioning

confidence: 99%

“… Hasuike et al 2019 described the use of the periosteum as a barrier for guided bone regeneration. The pedicle periosteum placed just above the bone defect acts more as a barrier rather than a resource of fibrous tissue in bone defects.…”

Section: Discussionmentioning

confidence: 99%

Buccal periosteal inversion (BUPI) for defect closure and keratinized gingiva width preservation after tooth extraction – technique modification

Arabadzhiev

Maurer

Stevao

2021

The Saudi Dental Journal

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Introduction Several techniques and methods have been proposed to cover alveolar bone after tooth extraction when soft tissue is lacking. Some authors recommend soft tissue flap techniques, and others advocate different types of materials for socket covering. In this article, the authors use a modified buccal inversion technique for adequate coverage of the alveolar ridge to ensure its preservation and to minimize soft tissue shrinkage and loss of keratinized gingiva after tooth extraction. This local mucogingival-periosteal plastic procedure was named by the authors the “Buccal Periosteal Inversion technique” or simply BUPI. Materials and Methods After extraction of a fractured, endodontically compromised lower right first molar, the BUPI technique was performed to cover the alveolus. After reflecting the two-sided full-thickness flap, the periosteum was split in the cranial direction. The inverted periosteum is used to provide tension-free defect closure of the postextractional defect. Detailed technique implementation and patient postoperative healing are presented here in detail. Results Postoperative evaluation at six weeks was presented with photos showing adequate surgical site healing, no signs of infection or dehiscence, and no crestal shift of the keratinized gingiva. Conclusion The buccal periosteal inversion (BUPI) technique is a modified technique that allows full socket coverage, avoiding a keratinized gingiva shift in the crestal direction using only the periosteum as a cover material. By inverting the buccal ridge periosteum alone from its normal position, the osteoclastic effect on the buccal bony wall will be eliminated, and this procedure abolishes the need for additional alveolar coverage materials.

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“…Our group examined the effects of the pedicle periosteum on bone regeneration in a rabbit calvarial-bone-defect model. Histological sections showed that the periosteum contributes to the formation of new bone by acting as a mechanical barrier and source of osteogenic factors [ 22 ]. From this perspective, our present approach using the periosteum tab would optimally utilize the properties of the periosteum.…”

Section: Discussionmentioning

confidence: 99%

Resorbable Membrane Pouch Technique for Single-Implant Placement in the Esthetic Zone: A Preliminary Technical Case Report

Funato¹,

Ishikura²,

Naito³

et al. 2022

Bioengineering

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The conventional protocol for lateral guided bone regeneration (GBR) in esthetic areas requires the securing of resorbable collagen membranes using titanium cortical bone pins to immobilize bone grafts. These procedures are highly invasive and can increase patient morbidity and discomfort. Herein, we introduce a minimally invasive novel resorbable membrane pouch technique, wherein collagen membranes can be immobilized by securing them to the periosteum without the need of titanium pins. We describe 11 cases of single-immediate- or delayed-implant placement in the atrophic maxilla esthetic zone. All implants were successful and functional without pain or inflammation and with optimal soft-tissue health and esthetics. Radiographic evaluation with cone-beam computed tomography (CBCT) and esthetic assessment using the pink esthetic score (PES) were performed. At the time of implant placement, the average augmented bone width was 2.8 ± 0.6 mm on CBCT analysis. In all cases, resorption of the augmented bone was confirmed with an average of −1.3 ± 0.8 mm. Soft-tissue outcomes were scored 1 year after permanent restoration. The PES score 1 year after treatment was 11.9 ± 1.4. The resorbable membrane pouch technique with immediate or delayed implant placement for buccal dehiscence in the esthetic area can be predictable and is minimally invasive.

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Pedicle Periosteum as a Barrier for Guided Bone Regeneration in the Rabbit Frontal Bone

Cited by 10 publications

References 16 publications

Membranes for Guided Bone Regeneration: A Road from Bench to Bedside

Membranes for Guided Bone Regeneration: A Road from Bench to Bedside

Buccal periosteal inversion (BUPI) for defect closure and keratinized gingiva width preservation after tooth extraction – technique modification

Resorbable Membrane Pouch Technique for Single-Implant Placement in the Esthetic Zone: A Preliminary Technical Case Report

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