Background: Palatal fistula after primary palate repair is an annoying problem for both patients and plastic surgeons. The incidence of fistula depends on the severity of the primary defect, the technique used for repair and the tension applied over the wound. Different methods are described for palatal fistula repair, starting from local mucoperiosteal flaps to free flaps.The recurrence rate of fistula after primary repair is about 23%, on the other hand the recurrence rate of fistula after its repair is higher as 25-33% up to 100%. Fistulas are classified according to its site and size. PRP is an autologous blood product, it promotes healing of wounds by its high platelet concentration and multiple growth factors, and also it decreases the risk of infection and increases neovascularization. PRP is used in several clinical applications as in oral maxillofacial, cardiac and plastic surgery.Methods: A comparative study was conducted on 20 patients with posterior palatal fistulas, who were divided into two groups, group A in which PRP was injected with fistula repair and group B fistula was repaired without PRP injection. Two flap palatoplasty (9 cases in each group) and Furlow technique (one case in each group) were used for both groups.Results: A total of 16 patients were followed-up for recurrence rate of fistulas, statistical analysis showed that in group A 25% had a recurrence, while in group B 50% of cases showed recurrence.Conclusion: PRP injection with the surgical repair of the palatal fistula has a role in decreasing the recurrence rate of the fistula and decreasing the need for further surgical interventions also, it is an easy, safe procedure and at an economic price.