Pedigree analysis of the Hungarian Thoroughbred population

Bokor, Árpád; Jonas, David; Ducro, B.J.; Nagy, I.; Bokor, Julianna; Szabari, M.

doi:10.1016/j.livsci.2012.10.010

Cited by 19 publications

(13 citation statements)

References 21 publications

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“…Moreover, we detected loss of founder representation since the previous study of Valera et al (2005), who reported an effective number of founders close to 40 compared with the 32 found in the present study for the PRE horse MP. This value is in the range of that found in other closed equine populations such as Spanish Arab horses (Delgado et al, 2014) or Thoroughbreds (Bokor et al, 2013;30 and 42, respectively). However, founder diversity reduction must be taken into account in future management policies to avoid a further decline in genetic variability and a considerable increase in inbreeding levels, especially in the case of small countries like Cuba.…”

Section: Discussionsupporting

confidence: 69%

Genetic structure and connectivity analysis in a large domestic livestock meta‐population: The case of the Pura Raza Español horses

Solé

Valera

Fernández

2018

J Animal Breeding Genetics

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The Pura Raza Español (PRE) is an autochthonous Spanish horse population distributed in 65 countries and managed by a single association. Since 1960s, breeding animals have been steadily exported to other countries to establish local subpopulations. We analysed the genetic structure of a PRE horse meta-population (MP) of 215,500 animals from countries with at least 80 active animals (27 countries comprising 77% of the total animals in the complete pedigree). Genotypes from active animals (59% of the total animals in the complete pedigree) were also studied. Genetic analysis of the MP was performed using classical parameters such as inbreeding (F), coancestry, founder contribution, effective number of founders/ancestors (fe/fa) and gene flow between countries. Results showed that the MPF coefficient decreased in the last two decades (1990-2013), indicating an explicit management against F. Founder contribution to genetic variability across countries mainly came from females (73.6%). In general, unbalanced contributions of founders reflected the high loss of genetic diversity along generations (fe/fa as low as 32/19 for the whole MP). Despite this differential contribution, the proportional contribution to the global diversity of each country was similar. The highest within-country coancestry value corresponded to Cuba (0.1509), being the only country with highly inbred individuals (over 12%), and the lowest value corresponded to Spain (0.0574). These results should help to avoid further declines in genetic variability and increases in F levels, especially in small countries like Cuba. In parallel, only nine countries presented descendants in a single population, suggesting a common origin for all countries and/or a substantial exchange of genetic material between populations. Spain and the US showed the highest gene flow rates. These results support the need of a coordinated management strategy, especially promoting the exchange of genetic material to increase the effective population size and maintain the levels of genetic diversity in the PRE horse population.

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Section: Discussionsupporting

confidence: 69%

Genetic structure and connectivity analysis in a large domestic livestock meta‐population: The case of the Pura Raza Español horses

Solé

Valera

Fernández

2018

J Animal Breeding Genetics

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“…Pedigree analysis also plays a key role in breeding programmes, which aim to maintain genetic diversity of endangered populations ( Bokor et al, 2013 ). Our further aim was to recognize overlapping haplotypes among mare families and thereby detect incidental errors in the Gidran stud book.…”

Section: Discussionmentioning

confidence: 99%

Genetic diversity of the Hungarian Gidran horse in two mitochondrial DNA markers

Sziszkosz

Mihok

Jávor

et al. 2016

PeerJ

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The Gidran is a native Hungarian horse breed that has approached extinction several times. Phylogenetic analysis of two mitochondrial markers (D-loop and cytochrome-b) was performed to determine the genetic characterization of the Gidran for the first time as well as to detect errors in the management of the Gidran stud book. Sequencing of 686 bp of CYTB and 202 bp of the D-loop in 260 mares revealed 24 and 32 haplotypes, respectively, among 31 mare families. BLAST analysis revealed six novel CYTB and four D-loop haplotypes that have not been previously reported. The Gidran mares showed high haplotype (CYTB: 0.8735 ± 0.011; D-loop: 0.9136 ± 0.008) and moderate nucleotide (CYTB: 0.00472 ± 0.00017; D-loop: 0.02091 ± 0.00068) diversity. Of the 31 Gidran mare families, only 15 CYTB (48.4%) and 17 D-loop (54.8%) distinct haplotypes were formed using the two markers separately. Merged markers created 24 (77.4%) mare families, which were in agreement with the mare families in the stud book. Our key finding was that the Gidran breed still possesses high genetic diversity despite its history. The obtained haplotypes are mostly consistent with known mare families, particularly when the two mtDNA markers were merged. Our results could facilitate conservation efforts for preserving the genetic diversity of the Gidran.

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“…This parameter varies considerably depending on population studied -e.g. for Hungarian Thoroughbred horses it reached 42, whereas for German Paint horses it exceeded 900 (Bokor et al, 2013;Siderits et al, 2013). Effective number of ancestors was smaller, and reached 16 and 11 for the Hucul, and Polish primitive horse.…”

Section: Mackowski Et Al: Genetic Diversity In Hucul and Polish Pmentioning

confidence: 93%

Genetic diversity in Hucul and Polish primitive horse breeds

et al. 2015

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Abstract. Pedigree and molecular data were used to evaluate genetic diversity in the Polish populations of the Polish primitive horse (also known as Polish Konik) and Hucul breeds over the time period of 30 years . Based on genotypes in 12 microsatellite loci (for 3865 Polish primitive horses and 1627 Huculs), as well as on pedigree data derived from over 7000 individuals (both breeds), several indices describing structure of the analysed populations were estimated. For both analysed breeds, we observed an increasing trend of inbreeding since 1980 which seems to be much more stable (oscillating around 10 % in the Polish primitive horse and 5 % in Hucul) since the beginning of 2000s when they were included in conservation programs in Poland. We observed that generally, indices related to genetic diversity are higher in the Hucul breed. Our study indicated that genetic diversity in the Polish primitive horse and Hucul breeds in Poland is still relatively high and conservation programs should be continued to keep it on the "safe" level in the future.

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Pedigree analysis of the Hungarian Thoroughbred population

Cited by 19 publications

References 21 publications

Genetic structure and connectivity analysis in a large domestic livestock meta‐population: The case of the Pura Raza Español horses

Genetic structure and connectivity analysis in a large domestic livestock meta‐population: The case of the Pura Raza Español horses

Genetic diversity of the Hungarian Gidran horse in two mitochondrial DNA markers

Genetic diversity in Hucul and Polish primitive horse breeds

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