PEDOT/MWCNT composite film coated microelectrode arrays for neural interface improvement

Chen, Sanyuan; Pei, Weihua; Gui, Qiang; Tang, Rongyu; Chen, Yuanfang; Zhao, Suoqi; Wang, Huan; Chen, Hongda

doi:10.1016/j.sna.2013.01.033

Cited by 80 publications

(51 citation statements)

References 26 publications

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“…[404] Typical existing CP/CNT composites are PEDOT/MWCNTs, [405] Ppy/SWCNTs, [280] Ppy/MWCNTs, [406] and PANI/SWCNTs. [407] For Ppy/SWCNTs homogeneous hybrid films, it was reported that the safe charge injection ( Q inj ) limit could be increased to ca.…”

Section: Electroactive Nanomaterials For Electrode-tissue Interfacesmentioning

confidence: 99%

A Review of Organic and Inorganic Biomaterials for Neural Interfaces

et al. 2014

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Recent advances in nanotechnology have generated wide interest in applying nanomaterials for neural prostheses. An ideal neural interface should create seamless integration into the nervous system and performs reliably for long periods of time. As a result, many nanoscale materials not originally developed for neural interfaces become attractive candidates to detect neural signals and stimulate neurons. In this comprehensive review, an overview of state-of-the-art microelectrode technologies provided first, with focus on the material properties of these microdevices. The advancements in electro active nanomaterials are then reviewed, including conducting polymers, carbon nanotubes, graphene, silicon nanowires, and hybrid organic-inorganic nanomaterials, for neural recording, stimulation, and growth. Finally, technical and scientific challenges are discussed regarding biocompatibility, mechanical mismatch, and electrical properties faced by these nanomaterials for the development of long-lasting functional neural interfaces.

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Section: Electroactive Nanomaterials For Electrode-tissue Interfacesmentioning

confidence: 99%

A Review of Organic and Inorganic Biomaterials for Neural Interfaces

et al. 2014

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“…The challenge for materials science is to apply nanotechnology strategies to fabricate biologically mimic materials which is soft, ionic, wet, and dynamic [5]. Several strategies have been proposed to improve the electrical properties and reactive tissue responses of neural electrodes, such as surface modification with bioactive conductive materials with nanostructures [6–10]. Surface modification with carbon nanotubes (CNTs) or conducting polymers (CP) such as polypyrrole (PPy) and poly(3,4-ethylenedioxythiophene) (PEDOT) can provide an excellent foundation for neural electrode design focused on improving the charge storage capacity and decreasing the interfacial impedance with neurons [11–13].…”

Section: Introductionmentioning

confidence: 99%

Topographic guidance based on microgrooved electroactive composite films for neural interface

Shi

Xiao

et al. 2016

Colloids and Surfaces B: Biointerfaces

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Topographical features are essential to neural interface for better neuron attachment and growth. This paper presents a facile and feasible route to fabricate an electroactive and biocompatible micro-patterned Single-walled carbon nanotube/poly(3,4-ethylenedioxythiophene) composite films (SWNT/PEDOT) for interface of neural electrodes. The uniform SWNT/PEDOT composite films with nanoscale pores and microscale grooves significantly enlarged the electrode-electrolyte interface, facilitated ion transfer within the bulk film, and more importantly, provided topology cues for the proliferation and differentiation of neural cells. Electrochemical analyses indicated that the introduction of PEDOT greatly improved the stability of the SWNT/PEDOT composite film and decreased the electrode/electrolyte interfacial impedance. Further, in vitro culture of rat pheochromocytoma (PC12) cells and MTT testing showed that the grooved SWNT/PEDOT composite film was non-toxic and favorable to guide the growth and extension of neurite. Our results demonstrated that the fabricated microscale groove patterns were not only beneficial in the development of models for nervous system biology, but also in creating therapeutic approaches for nerve injuries.

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“…Various research tools are available which enable recording of these signals, such as the Microelectrode Array (MEA) device. MEAs are devices consisting of a number of individually‐addressable electrodes in a specific pattern, used to record how bioelectrical signals propagate in a biological sample . Each of these electrodes ideally needs a small surface area (≤2500 μm 2 ) to ensure recording from a single biological cell.…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive Dopamine Detection Using a Bespoke Functionalised Carbon Nanotube Microelectrode Array

et al. 2017

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Understanding how the brain works requires developing advanced tools that allow measurement of bioelectrical and biochemical signals, including how they propagate between neurons. The introduction of nanomaterials as electrode materials has improved the impedance and sensitivity of microelectrode arrays (MEAs), allowing high quality recordings of single cells in situ using electrode diameters of ≤20 μm. MEAs also have the potential to measure electroactive biological molecules in situ, such as dopamine, a neurotransmitter in the nervous system. Thus, this work focused on fabricating a functionalised carbon nanotube (CNT)‐based MEA to demonstrate its potential for future measurement of small signals generated from excitable cells. To this end, the functionalised CNT MEA has recorded one of the lowest electrochemical interfacial impedances available in the literature, 2.8±0.2 kΩ, for an electrode of its geometric surface area. Electrochemical detection of dopamine revealed again one of the best sensitivity values per area available in the literature, 9.48 μA μM−1 mm−2. Additionally, a limit of detection of 7 nM was recorded for dopamine using the functionalised CNT MEA, with selectivity against common electrochemical interferents such as ascorbic acid. These results indicate improvement beyond currently available MEAs, along with the feasibility of using these devices for multi‐site detection of physiologically relevant electroactive biomolecules.

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PEDOT/MWCNT composite film coated microelectrode arrays for neural interface improvement

Cited by 80 publications

References 26 publications

A Review of Organic and Inorganic Biomaterials for Neural Interfaces

A Review of Organic and Inorganic Biomaterials for Neural Interfaces

Topographic guidance based on microgrooved electroactive composite films for neural interface

Highly Sensitive Dopamine Detection Using a Bespoke Functionalised Carbon Nanotube Microelectrode Array

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