PEDOT nanocomposites mediated dual-modal photodynamic and photothermal targeted sterilization in both NIR I and II window

Li, Luoyuan; Liu, Yuxin; Hao, Panlong; Wang, Zhangguo; Fu, Li‐Min; Ma, Zhanfang; Zhou, Jing

doi:10.1016/j.biomaterials.2014.10.075

Cited by 127 publications

(83 citation statements)

References 40 publications

(24 reference statements)

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“…Specifically, 1, 2‐distearoyl‐ sn ‐glycero‐3‐phosphoethanolamine‐N‐[methoxy(polyethylene glycol)‐2000 (DSPE‐PEG 2000 ) was used as the encapsulation matrix. In contrast to the synthesis of polypyrrole and PEDOT NPs, which require multiple steps to realize surface functionalization, our one‐step approach is a more general and straight forward method to obtain NPs bearing surface functional groups for further conjugation. The hydrodynamic diameters of N4 NPs were determined to be ≈50 nm by laser light scattering (LLS), see Figure A.…”

Section: Resultsmentioning

confidence: 99%

Encapsulated Conjugated Oligomer Nanoparticles for Real‐Time Photoacoustic Sentinel Lymph Node Imaging and Targeted Photothermal Therapy

Cai

Liu

Liao

et al. 2016

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Noninvasive and nonionizing imaging of sentinel lymph nodes (SLN) is highly desirable for the detection of breast cancer metastasis through sentinel lymph node biopsy. Photoacoustic (PA) imaging is an emerging imaging technique that can serve as a suitable approach for SLN imaging. Herein, novel conjugated oligomer based nanoparticles (NPs) with strong NIR absorption, good biocompatibility, excellent PA contrast, and good photothermal conversion efficiency are reported. Real-time PA imaging of SLN reveals high resolution of the NPs via injection from the left forepaw pad. In addition, the surface functionalized NPs can target breast cancer cells and kill them efficiently and specifically through photothermal therapy upon 808 nm laser irradiation. This work shows great potential of the nanoparticle PA contrast agent to serve as a multifunctional probe for photothermal therapy at SLNs to achieve the inhibition of cancer cell metastasis in the near future.

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Section: Resultsmentioning

confidence: 99%

Encapsulated Conjugated Oligomer Nanoparticles for Real‐Time Photoacoustic Sentinel Lymph Node Imaging and Targeted Photothermal Therapy

Cai

Liu

Liao

et al. 2016

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“…[41][42][43][44] Cellular and membrane integrity is considered to be one criterion distinguishing between viable and dead bacterial cells. Viable cells are assumed to have intact and tight cell membranes that cannot be penetrated by some staining compounds, whereas dead cells are considered to have disrupted and/or broken membranes.…”

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confidence: 99%

“…Septic processes account for approximately 73% of all death within the initial 5 days of a burn. 44,47 The presence of large amounts of necrotic tissue with protein-rich wound exudates at the burn site provides a highly nutritive medium for the proliferation of microbes, leading to increased rates of wound infection in these patients. 48,49 In this study, we demonstrated that it is possible to photoinactivate S. aureus rapidly when it is present in a burn wound with DVDMS as PS.…”

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confidence: 99%

Photodynamic antimicrobial chemotherapy for <em>Staphylococcus aureus</em> and multidrug-resistant bacterial burn infection in vitro and in vivo

Mai¹,

Gao²,

Li³

et al. 2017

IJN

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Background and objectives Antibiotic resistance has emerged as one of the most important determinants of outcome in patients with serious infections, along with the virulence of the underlying pathogen. Photodynamic antimicrobial chemotherapy (PACT) has been proposed as an alternative approach for the inactivation of bacteria. This study aims to evaluate the antibacterial effect of sinoporphyrin sodium (DVDMS)-mediated PACT on Staphylococcus aureus and multidrug resistant S. aureus in vitro and in vivo. Materials and methods Bacteria were incubated with DVDMS and exposed to treatment with light. After PACT treatment, colony-forming units were counted to estimate the bactericidal effect. Intracellular reactive oxygen-species production was detected by flow cytometry. Flow cytometry and fluorescence-microscopy detection of bacterial cell-membrane permeability. Enzyme-linked immunosorbent assays were used to determine expression of VEGF, TGFβ 1 , TNFα, IL6, and bFGF factors in burn infection. Results DVDMS-PACT effectively killed bacterial proliferation. Intracellular ROS levels were enhanced obviously in the PACT-treatment group. SYTO 9 and propidium iodide staining showed a decrease in the ratio of green:red fluorescence intensity in the PACT-treatment group in comparison to the control group. Enzyme-linked immunosorbent-assay results revealed that in the healing process, the expression of bFGF, TGFβ 1 , and VEGF in the treatment group were higher than in the control group, which inhibited inflammation-factor secretion. In addition, skin-tissue bacteria were reduced after treatment. Conclusion These results indicate that DVDMS-PACT presents significant bactericidal activity and promotes wound healing after burn infections.

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“…[3] PDT involves the generation of reactive oxygen species (ROS) which can destroy a broad spectrum of molecular targets such as proteins, lipids, and nucleic acids. [11,12] Heat and ROS attack bacteria at multiple sites and cause irreversible damages to the most elementary bacterial components. [11,12] Heat and ROS attack bacteria at multiple sites and cause irreversible damages to the most elementary bacterial components.…”

Section: Doi: 101002/adtp201900052mentioning

confidence: 99%

Glycosylated Copper Sulfide Nanocrystals for Targeted Photokilling of Bacteria in the Near‐Infrared II Window

Hou

Mahadevegowda

Cuong

et al. 2019

Advanced Therapeutics

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Photothermal and photodynamic therapies are established as alternative approaches to combating bacterial infections; however, the heat and reactive oxygen species generated by the photoagents act on both normal and bacterial cells. A targeting strategy is thus required to minimize side effects and enhance the antibacterial efficiency. Glycoconjugates specifically interacting with bacterial lectins have emerged as a new class of materials for targeting bacteria. In this paper, galactosylated plasmonic copper sulfide nanocrystals (Cu 2−x S NCs) are used to target Pseudomonas aeruginosa via galactose-LecA interactions and kill the bacteria by simultaneous photothermal and photodynamic therapy. Galactosylated Cu 2−x S NCs are obtained by functionalizing the nanocrystals with tri-thiogalactoside glycoclusters. The excellent specificity of galactosylated nanoparticles toward LecA with a LecA-deficient P. aeruginosa strain as the control is first demonstrated. Afterward, a laser in the near-infrared II window is used to kill the bacteria, and the critical role of targeted binding in efficient killing of bacteria is highlighted. This approach can be readily generalized to the targeting of other pathogens which have highly specific carbohydrate-binding lectins.

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PEDOT nanocomposites mediated dual-modal photodynamic and photothermal targeted sterilization in both NIR I and II window

Cited by 127 publications

References 40 publications

Encapsulated Conjugated Oligomer Nanoparticles for Real‐Time Photoacoustic Sentinel Lymph Node Imaging and Targeted Photothermal Therapy

Encapsulated Conjugated Oligomer Nanoparticles for Real‐Time Photoacoustic Sentinel Lymph Node Imaging and Targeted Photothermal Therapy

Photodynamic antimicrobial chemotherapy for <em>Staphylococcus aureus</em> and multidrug-resistant bacterial burn infection in vitro and in vivo

Glycosylated Copper Sulfide Nanocrystals for Targeted Photokilling of Bacteria in the Near‐Infrared II Window

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