PEDOT:PSS-Containing Nanohydroxyapatite/Chitosan Conductive Bionanocomposite Scaffold: Fabrication and Evaluation

Lari, Alireza; Sun, Tao; Sultana, Naznin

doi:10.1155/2016/9421203

Cited by 18 publications

(22 citation statements)

References 36 publications

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“…It is well-known that mechanical properties and cytocompatibility and are very important for the successful proliferation, growth, and differentiation of cell cultures. Thus, many studies on CP-based scaffolds focused on the incorporation of biopolymers such as collagen, 41,52 gelatin, 625,626 alginate, 626,627 chitosan, 628 silk fibroin, 629 and cellular-based gels, such as cardiogel. 455 Indeed, recent studies by our group demonstrated the use of PEDOT:PSS scaffolds containing collagen for enhancing the mechanical properties and promoting differentiation of neural crest stem (NCS) cells.…”

Section: D Cell Culturesmentioning

confidence: 99%

Organic Bioelectronics for In Vitro Systems

et al. 2021

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Bioelectronics have made strides in improving clinical diagnostics and precision medicine. The potential of bioelectronics for bidirectional interfacing with biology through continuous, label-free monitoring on one side and precise control of biological activity on the other has extended their application scope to in vitro systems. The advent of microfluidics and the considerable advances in reliability and complexity of in vitro models promise to eventually significantly reduce or replace animal studies, currently the gold standard in drug discovery and toxicology testing. Bioelectronics are anticipated to play a major role in this transition offering a much needed technology to push forward the drug discovery paradigm. Organic electronic materials, notably conjugated polymers, having demonstrated technological maturity in fields such as solar cells and light emitting diodes given their outstanding characteristics and versatility in processing, are the obvious route forward for bioelectronics due to their biomimetic nature, among other merits. This review highlights the advances in conjugated polymers for interfacing with biological tissue in vitro, aiming ultimately to develop next generation in vitro systems. We showcase in vitro interfacing across multiple length scales, involving biological models of varying complexity, from cell components to complex 3D cell cultures. The state of the art, the possibilities, and the challenges of conjugated polymers toward clinical translation of in vitro systems are also discussed throughout.

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Section: D Cell Culturesmentioning

confidence: 99%

Organic Bioelectronics for In Vitro Systems

et al. 2021

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“…They also found that both the compressive modulus and the yield strength of the chitosan increased to 0.5–1.0 MPa and 5–5.5 MPa, respectively, with the addition of nHAp and PEDOT: PSS. Unfortunately, the CS/nHAp/PEDOT: PSS had poor biodegradability, due to the strong bonding between PEDOT: PSS and the rest of the substrate chains [ 26 ]. Meanwhile, Iandolo et al (2020) prepared highly porous biomimetic scaffolds by combining the PEDOT: PSS with collagen type I (the most abundant protein in bone) for inactive support.…”

Section: Physical Properties Of Conductive-polymeric Scaffoldsmentioning

confidence: 99%

“…Another study demonstrated that the addition of conductive PEDOT: PSS in nHAp/chitosan composite scaffolds using the lyophilisation method reduced the scaffold’s biodegradability rate in the PBS solution. Although the scaffold with PEDOT: PSS had low biodegradability, its mechanical properties were consistent [ 26 ]. Lari et al (2020) attempted to decrease the wettability, while dialling up the mechanical properties, of PEDOT: PSS/nHA/CS biocomposite, by integrating polycaprolactone (PCL) into the scaffold.…”

Section: Common Conductive and Biodegradable Scaffoldsmentioning

confidence: 99%

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Advocating Electrically Conductive Scaffolds with Low Immunogenicity for Biomedical Applications: A Review

et al. 2021

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Scaffolds support and promote the formation of new functional tissues through cellular interactions with living cells. Various types of scaffolds have found their way into biomedical science, particularly in tissue engineering. Scaffolds with a superior tissue regenerative capacity must be biocompatible and biodegradable, and must possess excellent functionality and bioactivity. The different polymers that are used in fabricating scaffolds can influence these parameters. Polysaccharide-based polymers, such as collagen and chitosan, exhibit exceptional biocompatibility and biodegradability, while the degradability of synthetic polymers can be improved using chemical modifications. However, these modifications require multiple steps of chemical reactions to be carried out, which could potentially compromise the end product’s biosafety. At present, conducting polymers, such as poly(3,4-ethylenedioxythiophene) poly(4-styrenesulfonate) (PEDOT: PSS), polyaniline, and polypyrrole, are often incorporated into matrix scaffolds to produce electrically conductive scaffold composites. However, this will reduce the biodegradability rate of scaffolds and, therefore, agitate their biocompatibility. This article discusses the current trends in fabricating electrically conductive scaffolds, and provides some insight regarding how their immunogenicity performance can be interlinked with their physical and biodegradability properties.

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“…As a particular type of scaffold, conducting polymer scaffolds are currently interesting for their additional advantage of promoting cell growth by electrical stimulation. Conducting polymers used in tissue engineering are polypyrrole, , polyaniline, , polythiophenes, , and poly(3,4-ethylenedioxythiophene) (PEDOT). − They have been used to enhance bone, muscle, and nerve tissue regeneration . Moreover, they are also used in drug delivery, with drugs bound in the scaffolds and released through an electrical signal .…”

Section: Introductionmentioning

confidence: 99%

Conducting Polymer Scaffolds Based on Poly(3,4-ethylenedioxythiophene) and Xanthan Gum for Live-Cell Monitoring

et al. 2018

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Conducting polymer scaffolds can promote cell growth by electrical stimulation, which is advantageous for some specific type of cells such as neurons, muscle, or cardiac cells. As an additional feature, the measure of their impedance has been demonstrated as a tool to monitor cell growth within the scaffold. In this work, we present innovative conducting polymer porous scaffolds based on poly(3,4-ethylenedioxythiophene) (PEDOT):xanthan gum instead of the well-known PEDOT:polystyrene sulfonate scaffolds. These novel scaffolds combine the conductivity of PEDOT and the mechanical support and biocompatibility provided by a polysaccharide, xanthan gum. For this purpose, first, the oxidative chemical polymerization of 3,4-ethylenedioxythiophene was carried out in the presence of polysaccharides leading to stable PEDOT:xanthan gum aqueous dispersions. Then, by a simple freeze-drying process, porous scaffolds were prepared from these dispersions. Our results indicated that the porosity of the scaffolds and mechanical properties are tuned by the solid content and formulation of the initial PEDOT:polysaccharide dispersion. Scaffolds showed interconnected pore structure with tunable sizes ranging between 10 and 150 μm and Young’s moduli between 10 and 45 kPa. These scaffolds successfully support three-dimensional cell cultures of MDCK II eGFP and MDCK II LifeAct epithelial cells, achieving good cell attachment with very high degree of pore coverage. Interestingly, by measuring the impedance of the synthesized PEDOT scaffolds, the growth of the cells could be monitored.

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PEDOT:PSS-Containing Nanohydroxyapatite/Chitosan Conductive Bionanocomposite Scaffold: Fabrication and Evaluation

Cited by 18 publications

References 36 publications

Organic Bioelectronics for In Vitro Systems

Organic Bioelectronics for In Vitro Systems

Advocating Electrically Conductive Scaffolds with Low Immunogenicity for Biomedical Applications: A Review

Conducting Polymer Scaffolds Based on Poly(3,4-ethylenedioxythiophene) and Xanthan Gum for Live-Cell Monitoring

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