Pedunculated primary hepatocellular carcinoma

Cunningham, Peter; Nava, Hector; López, Cecilia; Douglass, Harold O.

doi:10.1002/jso.2930270414

Cited by 8 publications

(5 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, this is the largest series dealing with the surgical results of pedunculated HCCs. As shown in our results, the demographics, symptomatology, physical findings, biochemical data, hepatitis disease status, and associated liver condition were similar for the P-HCC and NP-HCC groups; in contrast, Cunningham et al reported in 1984, that P-HCC had less association with hepatitis B and ␣-fetoprotein [7]. Horie et al…”

Section: Discussionsupporting

confidence: 72%

Pedunculated Hepatocellular Carcinoma: Clinicopathologic Study of 18 Surgically Resected Cases

et al. 2002

View full text Add to dashboard Cite

We present the clinical features and outcomes of 18 surgically treated pedunculated hepatocellular carcinomas (P-HCCs). Hepatocellular carcinoma is a notorious, hyperendemic disease in Taiwan. Pedunculated HCC, although not a novel finding, has been recognized and diagnosed early by various imaging modalities. However, the clinicopathologic picture has not been fully clarified, and the prognosis varies in each report. From 1986 to 1998 the clinical features of 18 surgically treated cases of P-HCC were reviewed, including demographics, laboratory data, operative findings, pathologic features, and follow-up results. Factors that may influence the outcomes were also analyzed. Clinical features and outcomes of 414 patients with nonpedunculated hepatocellular (HCC) were summarized for comparison. Of 432 surgical resected hepatocellular carcinomas, 18 (4.2%) were P-HCCs. Larger tumor size, more capsule formation, less vascular invasion, and wider resection margins were significantly prominent in the patients in P-HCC group compared with those in the NP-HCC group. Multivariate stepwise logistic regression analysis revealed that the P-HCC group had significantly larger tumors and wider resection margins. The 1-, 3-, and 5-year survival rates of P-HCC patients were 88.3%, 77.4%, and 45.6%, respectively. A significant difference in survival was found between the P-HCC and NP-HCC groups. P-HCC patients without vascular invasion might have a significantly better survival demonstrated by log-rank analysis stratified by capsular invasion, vascular invasion, resection, and tumor size. We present the clinical features and outcomes of 18 surgically treated pedunculated HCCs. Pedunculated HCCs might have a better survival than conventional HCCs after hepatic resection, especially if there is no vascular invasion.

show abstract

Section: Discussionsupporting

confidence: 72%

Pedunculated Hepatocellular Carcinoma: Clinicopathologic Study of 18 Surgically Resected Cases

et al. 2002

View full text Add to dashboard Cite

show abstract

“…16 But, Cunningham et al reported that P-HCC is not related to hepatitis B virus infection and AFP. 17 In our case, laboratory findings including hepatitis B virus status and tumor markers were also unremarkable.…”

Section: Discussionsupporting

confidence: 48%

Giant pedunculated hepatocellular carcinoma masquerading as a pelvic mass: a case report

Jung

2014

Korean J Hepatobiliary Pancreat Surg

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is one of the most common malignancies in the world, with high frequency rates in Asia. Many of the patients have unresectable disease at the time of diagnosis, and early detection and surgical resection is the best hope for survival. But, if HCC is presenting as an extrahepatic mass, the diagnosis is difficult. Herein, we report a case of primary HCC masquerading as a pelvic mass. A 74-year-old woman was admitted to our hospital due to a palpable mass in the lower abdomen. CT scan detected an approximately 15.0×13.4×11.4 cm-sized multilobulated homogeneous enhancing mass in the right adnexa. Operative findings showed that the pelvic mass originated from the liver. We performed hepatic wedge resection. Permanent histopathologic report revealed primary HCC. Exophytic-growing hepatocellular carcinoma should be carefully diagnosed.

show abstract

“…The characterization of the nature of these tumors is of primary importance for their management and treatment. Specific imaging features, such as "prominent feeding artery sign", dynamic diffuse enhancement pattern during hepatic arterial phase, and fatty components are useful for identifying the origin and nature of liver tumors [ 6 , 8 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

Giant pedunculated hepatocellular carcinoma with hemangioma mimicking intestinal obstruction

et al. 2011

View full text Add to dashboard Cite

BackgroundPedunculated hepatocellular carcinoma (P-HCC) has rarely been reported and is characteristically large and encapsulated. Only sporadic cases have been published, in which P-HCC was combined with other liver tumors (mostly benign), making the diagnosis difficult.Case presentationWe report a patient who was admitted to our hospital with clinical features of intestinal obstruction and a palpable mass in the right iliac fossa. Ultrasound, computed tomography and magnetic resonance imaging demonstrated an encapsulated mass of unclear origin and characteristics of liver hemangioma. Laboratory tests revealed elevated α-fetoprotein (> 800 ng/ml) and cancer antigen 125 (> 51.2 U/ml). With a possible diagnosis of giant liver hemangioma, we proceeded to surgery. During surgery, a giant pedunculated tumor was discovered on the inferior surface of the right lobe of the liver, hanging free in the right abdominal cavity towards the right iliac fossa. The macroscopic appearance of the tumor was compatible with liver hemangioma. Tumor resection was performed at a safe distance, including the pedicle. The rest of the liver appeared normal. Histopathological examination revealed grade II and III HCC (according to Edmondson-Steiner's classification) with nodular configuration, central necrosis, and infiltration of the capsule. Underneath the tumor capsule, residual tissue of a cavernous hemangioma was recognized. The resection margins were free of neoplastic tissue.ConclusionThis rare presentation of a giant P-HCC combined with a hemangioma with features of intestinal obstruction confirmed the diagnostic difficulties of similar cases, and required prompt surgical treatment. Therefore, patients benefit from surgical resection because both the capsule and the pedicle prevent vascular invasion, therefore improving prognosis.

show abstract

Pedunculated primary hepatocellular carcinoma

Cited by 8 publications

References 16 publications

Pedunculated Hepatocellular Carcinoma: Clinicopathologic Study of 18 Surgically Resected Cases

Pedunculated Hepatocellular Carcinoma: Clinicopathologic Study of 18 Surgically Resected Cases

Giant pedunculated hepatocellular carcinoma masquerading as a pelvic mass: a case report

Giant pedunculated hepatocellular carcinoma with hemangioma mimicking intestinal obstruction

Contact Info

Product

Resources

About