Peel-off gel formulation from black mulberries (Morus nigra) extract as anti-acne mask

Budiman, Arif; Aulifa, Diah Lia; Kusuma, Arif Satria Wira; Kurniawan, Insan Sunan; Sulastri, Astri

doi:10.5455/njppp.2017.7.0413123052017

Cited by 27 publications

(32 citation statements)

References 11 publications

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“…Also, maceration method was adopted in the extraction process, in an attempt to protect compounds, especially those responsible for the inhibition of α-glucosidase enzyme, contained in the BM leaves from thermal decomposition. [ 11 ] Furthermore, 70% ethanol was used as a solvent, based on the universal dissolution characteristics for both polar and nonpolar constituents,[ 20 ] producing a rendement value of 21.83%.…”

Section: R Esult and Discussionmentioning

confidence: 99%

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The formulation of lozenge using black mulberries (Morus nigra L.) leaf extract as an α-glucosidase inhibitor

et al. 2020

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A BSTRACT Background: Diabetes mellitus is a chronic metabolic disease, which possibly leads to kidney, brain, heart failure, and other organ complications, subsequently harming human health. These symptoms have been prevented using the leaf of black mulberry (BM), as a traditional medicine, because the phenolic compounds contained are able to decrease blood glucose concentration. Meanwhile, previous reports have shown that BM contains 1-deoxynojirimycin, with strong activity as an α-glucosidase inhibitor. The aim of this study, therefore, was to formulate and evaluate BM leaf extract in lozenge dosage form as an α-glucosidase inhibitor. Materials and Methods: The leaves of BM were extracted using the maceration method, where ethanol (70%) served as a solvent, and the inhibitory activity of the sourced α-glucosidase enzyme was determined through in vitro study. Subsequently, the extract was formulated into lozenge dosage form and evaluated for physical stability and also the effect of α-glucosidase enzyme. Results: The result showed an inhibitory activity of BM leaf extract against the enzyme α-glucosidase, with a half maximal inhibitory concentration (IC 50 ) value of 357.6 μg/mL, whereas the lozenge formulation containing 43% of extract as well as 5% polyvinylpyrrolidone showed the best physical stability as compared to other formulas. However, the lozenge inhibits α-glucosidase enzyme with an IC 50 value of 549.7 μg/mL. Conclusion: It was established that the lozenge of BM leaf extract possesses activity as an α-glucosidase inhibitor.

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Section: R Esult and Discussionmentioning

confidence: 99%

“…Phytochemical screening was conducted to evaluate the presence of secondary metabolites, including flavonoids, alkaloids, polyphenols, tannins, saponins, quinones, steroids/triterpenoids, monoterpenes, and sesquiterpenes. [ 11 ]…”

Section: Aterials and M Ethodsmentioning

confidence: 99%

The formulation of lozenge using black mulberries (Morus nigra L.) leaf extract as an α-glucosidase inhibitor

et al. 2020

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“…Linear regression curve between %inhibition and sample concentration was made, and the linear equation and IC 50 values were obtained. [16]…”

Section: Methodsmentioning

confidence: 99%

Formulation of antioxidant gel from black mulberry fruit extract (Morus nigra L.)

et al. 2019

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A bstract Background: Ultraviolet (UV) radiation from the sun that is composed of UVA and UVB can cause premature aging when exposed to the skin. Black mulberry fruit ( Morus nigra L.) contains anthocyanins as antioxidants that can be protective against UV exposure. The aim of this research was to produce gel formulation from the extract of black mulberry as an antioxidant and sunscreen. Materials and Methods: This research started with the maceration process using 96% ethanol solvent. Later, antioxidant activity of the extract was determined using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method and compared with vitamin C. Furthermore, the extracts were formulated into gel with variations of hydroxypropyl methylcellulose, sodium carboxymethyl cellulose, Carbopol 934, and extract concentrations. The products were then physically evaluated, including organoleptic evaluation, homogeneity, pH, viscosity, and dispersion, as well as the hedonic test, irritation test, and antioxidant activity test. Results: The results showed that black mulberry extract had antioxidant activity with the half maximal inhibitory concentration (IC 50 ) value of 146.73ppm and its antioxidant strength was 39.6 times lower than that of vitamin C. The formulation with best physical evaluation results was given by formula 4 (Carbopol 934, 1.5%) with extract concentration 0.61%. This formula showed antioxidant activity with an IC 50 value of 104.659ppm. Furthermore, on the basis of hedonic test and irritation test, this formula was the most popular and was categorized as a safe topical gel. Conclusion: The gel of black mulberry extract had antioxidant activity and was categorized as a safe topical gel.

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“…The black mulberry fruit (Morus nigra L.) is mostly used to produce foods, such as juice, jam, alcoholic drinks, natural dyes and ice cream 6 . In addition, it can also be used to treat dysentery and may act as a laxative, odontalgia, antiacne, anthelmintic, expectorant, hypoglycemic and emetic agent 5,8,9 .…”

Section: Ethnomedicinal Morus Nigra Lmentioning

confidence: 99%

Chemical Compounds and Pharmacological Activity of Morus Nigra as a Potential Product of Drug: A Review

Budiman¹,

Sulastri²,

Qoriah³

2018

Int. Res. J. Pharm.

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Black mulberry fruit (Morus nigra L.) is spread over the subtropical regions of the earth and can grow in various topography and climatic conditions. Its fruit mostly proceeds to become juice, jam, coloring agent and a flavoring for ice cream. Traditionally, the leaves and fruit of Morus nigra L. are used to treat dysentery, diabetes mellitus, hypertension, arthritis, and anemia and can also act as a laxative, odontalgia, anthelmintic, expectorant, hypoglycemic and emetic agent. These pharmacological activities might be caused by a high amount of active compounds in black mulberry. Based on the literature studies, there are 56 compounds isolated from various parts of black mulberry, including the root bark, roots, bark, wood, leaves and fruit. The chemical constituents found in black mulberry contribute to its pharmacological properties, such as antihyperglycemic, cytotoxic against leukemia cells, antioxidative, antibacterial, anti-inflammatory and inhibition of tyrosinase.

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Peel-off gel formulation from black mulberries (Morus nigra) extract as anti-acne mask

Cited by 27 publications

References 11 publications

The formulation of lozenge using black mulberries (Morus nigra L.) leaf extract as an α-glucosidase inhibitor

The formulation of lozenge using black mulberries (Morus nigra L.) leaf extract as an α-glucosidase inhibitor

Formulation of antioxidant gel from black mulberry fruit extract (Morus nigra L.)

Chemical Compounds and Pharmacological Activity of Morus Nigra as a Potential Product of Drug: A Review

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