Background: Few researchers have examined young adolescents’ perceived qualities and satisfaction in their relationships with their mothers, fathers and best friends simultaneously, using a cross-cultural perspective. This study aimed to compare the perceived qualities and satisfaction of USA and Portuguese adolescents in their relationships with their parents and best friends and to examine the influence of perceived relationship qualities on the satisfaction of young adolescents with their close relationships. Methods: The sample consisted of 347 USA adolescents (170 boys, 177 girls) and 360 Portuguese adolescents (176 boys, 184 girls) who completed the Network of Relationships Inventory Social Provision Version to assess perceived support, negativity, power balance and satisfaction in their relationships with their mothers, fathers and same-sex best friends. Results: Adolescents from both countries perceived their relationships with parents to be more negative and imbalanced in power than their relationships with friends, but the magnitude of differences was greater in the USA. Furthermore, USA adolescents reported higher satisfaction in their relationships with friends than in their relationships with parents. Country differences in the concomitants of relationship satisfaction were found. Conclusions: These findings support the notion that young adolescents’ perceived qualities and satisfaction in close relationships may differ depending on cultural norms.