Peer influences on drug self-administration

Peitz, Geoffrey W.; Strickland, Justin C.; Pitts, Elizabeth G.; Foley, Mark; Tonidandel, Scott; Smith, Mark A.

doi:10.1097/fbp.0b013e32835f1719

Cited by 30 publications

(8 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although our data suggest that the presence of an abstaining partner will not prevent the development of dysregulated patterns of cocaine intake, they do suggest that the presence of an abstaining partner will limit overall cocaine intake, thus limiting the harmful consequences of drug exposure during both early and late stages of a cocaine use disorder. These findings are consistent with a recent behavioral economic study in which rats with a social partner without access to cocaine self-administered less cocaine than isolated rats and rats with a social partner with access to cocaine (Peitz et al, 2013). In that study, isolated rats did not differ from rats with a partner with access to cocaine, similar to that observed in Experiment 1.…”

Section: Discussionsupporting

confidence: 92%

The effects of social contact on cocaine intake under extended-access conditions in male rats.

Robinson

Lacy

Strickland

et al. 2016

Experimental and Clinical Psychopharmacology

Self Cite

View full text Add to dashboard Cite

Social learning theories of drug use propose that drug use is influenced by the behavior of peers. We previously reported that cocaine self-administration under limited-access conditions can either be facilitated or inhibited by social contact depending on the behavior of a peer. The purpose of this study was to determine if social contact influences cocaine self-administration under conditions that are more representative of problematic patterns of drug use. Male rats were assigned to either isolated or pair-housed conditions in which a social partner either had access to cocaine or did not have access to cocaine. Pair-housed rats were tested in custom-built operant conditioning chambers that allowed both rats to be tested simultaneously in the same chamber. In Experiment 1, rats were tested for 14 consecutive days during daily 6-hr test sessions. In Experiment 2, different doses of cocaine were tested in 23-hr test sessions conducted every three days. All groups of rats escalated their cocaine intake in Experiment 1; however, pair-housed rats with a partner without access to cocaine had lower levels of intake throughout the 14 days of testing. In Experiment 2, pair-housed rats with a partner without access to cocaine had lower levels of cocaine intake than rats with a partner with access to cocaine, and this effect was observed at all doses of cocaine tested. These data indicate that the behavior of a social partner (i.e., whether or not that partner is also self-administering cocaine) influences cocaine self-administration under conditions that model problematic patterns of drug use.

show abstract

Section: Discussionsupporting

confidence: 92%

The effects of social contact on cocaine intake under extended-access conditions in male rats.

Robinson

Lacy

Strickland

et al. 2016

Experimental and Clinical Psychopharmacology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Cocaine choice for both unit doses decreased when the money alternative amount was larger ($3) compared to when it was smaller ($1); this finding is consistent with results from preclinical studies (Nader and Woolverton, 1991; Nader et al, 1993; Woolverton et al, 1997; Rodefer et al, 1997; Peitz et al, 2013), human laboratory studies (Donny et al, 2003, 2004; Higgins et al, 1994a; Stoops et al, 2012) and clinical trials (Higgins et al, 1991, 1994b, 2000, 2007; Petry et al, 2004; Rothfleisch et al, 1999), which supports the validity of this study and provides a platform for the more novel investigation of reinforcement probability.…”

Section: Discussionsupporting

confidence: 83%

Effect of experimental analogs of contingency management treatment on cocaine seeking behavior

Greenwald

Ledgerwood

Lundahl

et al. 2014

Drug and Alcohol Dependence

View full text Add to dashboard Cite

Background Contingency management (CM) treatment is effective for treating cocaine dependence but further mechanistic studies of its efficacy are warranted. This study aimed to determine whether: (a) higher vs. lower predictable money amounts ($3 vs. $1; analogs of standard voucher-based CM) increase cocaine demand elasticity; and (b) probabilistic amounts matched for expected value with the $3-predictable amount (50% chance of $6; 25% chance of $12; and 12.5% chance of $24; analogs of prize CM) similarly affect cocaine choice. Methods Each of 15 cocaine-dependent participants first completed a qualifying session to ensure that intranasal cocaine functioned as a reinforcer, then completed a 10-session, within-subject, randomized crossover study. During each of the 10 sessions, the participant responded on a progressive ratio schedule to earn units of cocaine (5-mg or 10-mg) and/or money (five monetary conditions above). Results During the reinforcement qualifying session (10-mg vs. 0-mg units; no money alternative), cocaine choice was high. The $3-predictable amount significantly decreased cocaine choice relative to both the $1-predictable amount and the qualifying session. Cocaine-choices in the probabilistic conditions were similar to the $3 predictable condition. Conclusions These findings indicate that CM interventions targeted at reducing cocaine self-administration are more likely to succeed with higher value non-drug reinforcement.

show abstract

“…The present study provides a perspective that relapsed and unrelapsed partners produce different effects on relapse. Our results and previous findings confirmed the social-learning theory ( Peitz et al, 2013 ) which demonstrates that partners of a group affect the behavior of other members.…”

Section: Discussionsupporting

confidence: 91%

Social Interaction With Relapsed Partner Facilitates Cocaine Relapse in Rats

et al. 2021

View full text Add to dashboard Cite

Social factors strongly contribute to drug use and relapse, and epidemiological studies have found that members of peer groups influence each other to use drugs. However, previous animal models mostly failed to incorporate social factors and demonstrate the effects of social partners on drug addiction and relapse. In the present study, we investigated the transfer of relapse to cocaine seeking between drug-addicted partners in rats. Male Sprague–Dawley rats were pair-housed and subjected to training and extinction of cocaine self-administration and conditioned place preference (CPP). 24 h after extinction test, the targeted rats interacted with a cocaine-primed (relapsed) partner or stranger, or saline-injected (unrelapsed) partner for 30 min, after which the targeted rats were tested for drug seeking behavior. We found that social interaction with a relapsed partner increased drug seeking behavior in cocaine self-administration and CPP models in rats, while social interaction with an unrelapsed partner or relapsed stranger had no effect on cocaine seeking. Moreover, the effect of social interaction on cocaine seeking could last for at least 1 day. Our findings demonstrate a facilitation effect of relapsed social partners on drug relapse in rats and provide a novel animal model for social transfer of drug relapse.

show abstract

Peer influences on drug self-administration

Cited by 30 publications

References 52 publications

The effects of social contact on cocaine intake under extended-access conditions in male rats.

The effects of social contact on cocaine intake under extended-access conditions in male rats.

Effect of experimental analogs of contingency management treatment on cocaine seeking behavior

Social Interaction With Relapsed Partner Facilitates Cocaine Relapse in Rats

Contact Info

Product

Resources

About