Peer Review #1 of "Assessment of three risk evaluation systems for patients aged ≥70 in East China: performance of SinoSCORE, EuroSCORE II and the STS risk evaluation system (v0.1)"

Abstract

Objectives:To assess and compare the predictive ability of three risk evaluation systems (SinoSCORE, EuroSCORE II and STS risk evaluation system) in patients aged≥70 , and who underwent coronary artery bypass grafting (CABG) in East China.Methods: Three risk evaluation systems were applied to 1946 consecutive patients who underwent isolated CABG from January 2004 to September 2016 in two hospitals. Patients were divided into two subsets according to their age: elderly group (age≥70) with a younger group (age<70) used for comparison. The outcome of interest in this study was in-hospital mortality. The entire cohort and subsets of patients were analyzed. The calibration and discrimination in total and in subsets were assessed by the Hosmer-Lemeshow and the C statistics respectively. Results: Institutional overall mortality was 2.52%. The expected mortality rates of SinoSCORE, EuroSCORE II and STS risk evaluation system were 0.78(0.64)%, 1.43(1.14)% and 0.78(0.77)%, respectively. SinoSCORE achieved the best discrimination (the area under the receiver operating characteristic curve (AUC) =0.829), followed by STS risk evaluation system (AUC=0.790) and EuroSCORE II (AUC=0.769) in the entire cohort. In the elderly group, the observed mortality rate was 4.82% while it was 1.38% in the younger group. SinoSCORE (AUC=0.829) also achieved the best discrimination in the elderly group, followed by STS risk evaluation system (AUC=0.730) and EuroSCORE II (AUC=0.640) while all three risk evaluation systems all had good performances in the younger group. SinoSCORE, EuroSCORE II and STS risk evaluation system all achieved positive calibrations in the entire cohort and subsets. Conclusion: The performance of the PeerJ reviewing PDF | Manuscript to be reviewed three risk evaluation systems was not ideal in the entire cohort. In the elderly group, SinoSCORE appeared to achieve better predictive efficiency than EuroSCORE II and STS risk evaluation system.PeerJ reviewing PDF |