Peer Review #1 of "Comparison of routine hematological indicators of liver and kidney function, blood count and lipid profile in healthy people and stroke patients (v0.2)"

Abstract

Background and methods: Stroke has become a major public health problem worldwide. In this paper, we carried out statistical analysis, correlation analysis and principal component analysis to evaluate the clinical value of routine hematological indicators in early diagnosis of ischemic stroke using R language. Results: For the full blood count comparisons, stroke patients had obvious differences in the distribution width of red blood cells (RDW-CV), average distribution width of red blood cells (RDW-SD), mean hemoglobin concentrations, platelet large cell ratio, mean platelet volume and lymphocytes. Patients with ischemic stroke also exhibited different degrees of abnormalities in liver function test. With respect to renal function, stroke patients had obvious changes in uric acid and urea levels. Finally, when comparing the lipid profile, triglyceride concentrations were increased and high-density lipoprotein cholesterol concentrations were reduced in stroke patients. In addition, correlation analysis among these clinical indicators indicated that there were both common characteristics and differences between patients and health controls . Furthermore, the results of principal component analysis indicated that these clinical indicators could distinguish patients from the healthy controls. Conclusion: Conventional hematological clinical indicators, such as liver function, renal function, full blood count and lipid concentration profiles highly correlated with the occurrence of ischemic stroke. Therefore, the detection and analyzation of these clinical indicators are of great significance for the prediction of ischemic stroke.