2021
DOI: 10.7287/peerj.10671v0.1/reviews/1
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Peer Review #1 of "RNA sequencing analysis of FGF2-responsive transcriptome in skin fibroblasts (v0.1)"

Abstract: Background: Fibroblast growth factor 2 (FGF2) is a highly pleiotropic cytokine with antifibrotic activity in wound healing. During the process of wound healing and fibrosis, fibroblasts are the key players. Although accumulating evidence has suggested the antagonistic effects of FGF2 in the activation process of fibroblasts, the mechanisms by which FGF2 hinders the fibroblast activation remains incompletely understood. This study aimed to identify the key genes and their regulatory networks in skin fibroblasts… Show more

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