Peer Review #3 of "A 22-amino-acid peptide regulates tight junctions through occludin and cell apoptosis (v0.1)"
Abstract:Occludin is a structural protein of tight junctions (TJ) in the blood-testis barrier (BTB). A 22amino-acid peptide (22AA) in the second extracellular loop can reversibly regulate TJ, but its regulatory mechanism is unknown. In this study, a 22AA-induced TJ destruction animal model was constructed to investigate the effect of 22AA on Sertoli cells (SCs) and spermatid count s and cell apoptosis at different time points using a multiplex immunofluorescence technique. The effect of 22AA on the location and distrib… Show more
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